The Relationship Between Carotid Artery Intima Media Thickness and Mean Platelet Volume In Hemodialysis Patients

Öz

Objective: Chronic kidney disease is closely associated with cardiovascular disease. The prevalence and mortality rates of cardiovascular disease in patients with chronic kidney disease are significantly higher compared to those in the general population. Atherosclerosis is known to be the primary underlying pathology of cardiovascular disease, and carotid artery intima-media thickness (CIMT) is considered the most reliable indicator indicator of atherosclerosis. This study aimed to examine the relationship between mean platelet volume (MPV) and CIMT in patients undergoing hemodialysis. Methods: Data from 50 patients undergoing hemodialysis were retrospectively analyzed. Demographic characteristics, vital signs, chronic diseases, and laboratory results of the patients were collected. Descriptive statistics were expressed as mean, standard deviation, frequency, and percentage. Statistical analyses were performed using SPSS software (IBM SPSS for Windows, version 26), and a significance level of p<0.05 was considered statistically significant. Results: Elevated CIMT was found in 24 of the 50 patients studied. Mean platelet volume was higher in patients with elevated CIMT (11.57 fl) compared to those with normal CIMT (10.88 fl), and the difference between the groups was statistically significant (t-test sd: 0.98, p<0.05). Correlation analysis revealed a statistically significant, positive correlation between CIMT and MPV (r: 0.158, p<0.001). Conclusion: Mean platelet volume was found to be elevated in patients with increased CIMT. MPV is associated with atherosclerosis and suggesting MPV as a potential marker for cardiovascular risk in hemodialysis patients.

Anahtar Kelimeler

• Carotid artery intima-media thickness
• mean platelet volume
• end-stage renal disease

Hemodiyaliz Hastalarında Karotis Arter İntima Media Kalınlığı İle Ortalama Trombosit Hacmi Arasındaki İlişkinin Araştırılması

Öz

Amaç: Kronik böbrek hastalığı kardiyovasküler hastalık ile yakından ilişkilidir. Kronik böbrek hastalığında kardiyovasküler hastalık prevalansı ve mortalitesi genel popülasyona göre daha yüksektir. Kardiyovasküler hastalığın lezyonu olarak ateroskleroz olduğu ve bunun da en iyi göstergesi olarak karotis arter intima media kalınlığının kullanıldığı bilinmektedir. Bu çalışmada, hemodiyaliz hastalarında ortalama trombosit hacmi ile karotis arter intima media kalınlığı ile ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Diyalize giren 50 hastanın verileri retrospektif olarak incelendi. Hastaların demografik özellikleri, vitalleri, kronik hastalıkları ve laboratuvar sonuçları incelendi.Tanımlayıcı istatistiklere bakıldığında; ortalama, standart sapma, sayı ve yüzde olarak ifade edildi. Bütün analizlerde SPSS (IBM SPSS for Windows, ver.26) istatistik paket programı kullanılmış ve anlamlılık düzeyi için p <0.05 değeri anlamlı kabul edildi. Bulgular: Çalışmamızda 50 hastanın 24’ünde karotis arter intima media kalınlığını yüksek bulunmuştur. Karotis arter intima media kalınlığı yüksek çıkan hastalarda ortalama trombosit hacmi ortalaması 11.57 fL, normal olanlarda 10.88 fL olarak saptanmıştır. Gruplar arasındaki fark istatistiksel olarak anlamlı bulunmuştur (t-test sd: 0.98, p<0.05). Karotis arter intima media kalınlığı ve ortalama trombosit hacmi arasında yapılan korelasyon analizinde anlamlı, pozitif yönde ve düşük düzeyde bir ilişki saptanmıştır (r: 0.158, p<0.001). Sonuç: Karotis arter intima media kalınlığı yüksek olan hastalarda ortalama trombosit hacmi yüksek bulunmuştur. Ortalama trombosit hacmi ateroskleroz ile ilişkili bulunmuş olup ve kardiyovasküler hastalık riski açısından dikkate alınmalıdır.

Anahtar Kelimeler

• Karotis arter intima media kalınlık
• ortalama trombosit hacmi
• son dönem böbrek yetmezliği

Kaynakça

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