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KARACİĞER VE GASTROİNTESTİNAL SİSTEM HASTALIKLARINDA SER UM C VİTAMİNİ, Beta -KAROTEN VE RETİNOL DÜZEYLERİ

Yıl 2018, Cilt: 11 Sayı: 2, 6 - 10, 15.12.2018

Öz

Gastroindestinal sistem hastalıkları dünya çapında önemli morbitide ve mortalite nedenleridir. Antioksidan özelliğe sahip vitamin C, b- karoten ve retinol, gastrointestinal sistem hastalıkla
ve
kanserle rde lipid peroksidasyonu ve
serbest
radikal gelişiminin önlenmesinde
önemli role sahiptir. Bu ça lış manın
amac ı, antioksidan özelliğe
sahip vitamin C,
b-karoten ve retinolün serum düzeyleriyle ülser, siroz, özefagus ve mide
kanser hastalıkları arasındaki
ilişkiyi değerlendirmektir. Çalışmada  35 ülserli,



40   özefagus   kanserli,  30   mide  
kanserli, 25



karac iğer siro zlu
hasta ile 50 sağlıklı birey
serumlarında, C vitamini,
b-karoten
ve
retinol düzeyleri                           değerlendirildi.             Vitaminler spektrofotometrik olarak analiz
edildi. Hasta gruplarının serum C vitamini düzeylerinin kontrol grubu ile karşılaştırılmasında, ülserli
hastalarda azalma ve özofagus kanserli hastalarda artış
istatistiksel olara k an la mlıydı
(p<0.05). Mide kanseri ve sirozlu hasta
vitamin C düzeylerinde istatistik olara k bir fark bulunamadı
(p>0.05).
b-karoten ve retinol düzeyleri,
ülserli hastalarda yüksek, özefagus ve sirozlu
hastalarda düşük olarak saptandı
(p<0.05). Mide kanserli hastalarda serum
b- karoten ve retinol
düzeylerinde istatistik anlam yoktu
(p>0.05). Özefagus-mide kanserlerinde ve karaciğer
sirozunda
b-karoten ve retinol önemli oranda azaldı,
C vitamini ise yükseldi. Sonuç olarak
bu çalışmadan elde edilen verilerin
antioksidan ajanların diyette yer almasının bu hastalıkla rın önlen
mesi ve ilerle mesin in durdurulmasında koruyucu rol üstlenebileceğine dair açısından yararlı bilg iler sunacağı kanaatine varıld ı.

Kaynakça

  • Abnet CC, Qiao YL, Davsey SM, Buckman DW, Yang CS, Blot WJ, et al. Prospective study of serum retinol, beta-carotene, betacryptoxanthin, and lutein/z eaxant hin and esophageal and gastr ic cancers in China. Canc er Causes Control 2003; 14(7):645- 55.
  • Aditi A, and Gr aham DY. Vitamin C, gastr itis, and gastric disease: A historical review and update. Dig Dis Sci 2012; 57(10):2504-15.
  • Akkuş İ. Serbest Radikaller ve Fizyopatolojik Etkileri. Kony a, Mimoza Yayınl arı,1995. Alcant ara EN, Speckmann EW. Diet, nutrition, and cancer. Am J Clin Nutr 1976;29: 1035-47.
  • Almushatat AS, Tavlar D, McArdle PA, Williamson C, Sattar N, O’r eil ly DS, et al. Vitamin antio xidant , lipid peroxidat ion and the systemic inflammatory response in patients with prostate cancer. Int J Cancer 2005;118(4),1051-3.
  • Azevedo LF, Salgueiro LF, Claro R, Teixeir a-Pinto A, Costa- Pereira A. Diet and gastric cancer in Portugal-a multiv ariate model. Eur J Cancer Prev 1999;8(1):41- 8.
  • Bollag W, Holdener EE. Retinoids in cancer prev ention and therapy. Ann Oncol. 1992; 3(7):513-26. Chamras H, B arsky SH, Ardashian A, Nav asartian D, H eber D, Glaspy JA. Nov el interact ions of vit amin-E and estrogen in breast cancer. Nutr Cancer 2005;52(1), 43–8.
  • Dündar Y, Aslan R. H ekimlikte Oksidatif Stres ve Antioksidanlar , Afyon. Afyon Kocatepe Üniversit esi Yayınl arı, 2000.
  • Dursun H, Bilici M, Uyanık A, Okcu N, Akyüz M. Antioxidant enzyme activities and lipid peroxidatio n lev els in erythrocytes of patients with oesophageal and gastric canc er. J I nter Med Res 2006; 34: 193-9.
  • Fu Y, Yang G, Zhu F, Peng C, Li W, Li H, et al. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulat ing Src-dep endent caspas e-7 phosphorylation. Cell Death Dis. 2014; 5(1):983.
  • Goodman GE, Alberts DS, Meyskens FL. Retinol, vitamins, and canc er prev ention: 25 years of l earning and r el ear ning. J Clin Oncol 2008;26: 5495-6.
  • Halliw ell B. Antioxidants and human disease: A gener al introduct ion. Nutr Rev 1997;55: 44-52.
  • Ito Y, Kurata M, Hioki R, Suzuki K, Ochiai J, Aoki K. Cancer mortality and s erum levels of carotenoids, r etino l, and tokopherol: A population-based follow-up study of inhabit ants of a rur al area of Japan. Asian Pac J Cancer Prev 2005;6(1):10- 5.
  • Jenab M, Salvini S, Gils CHV, Brustad M, Shaky a-Shrestha S, Buijsse B, et al. Dietary intakes of r etinol, -carotene, vitamin D and vitamin E in the European Prospective investigatio n into Cancer and Nutrit ion cohort. Eur J Clin Nutr 2009;63:150-78.
  • Marceau G, Gallot D, Lemery D, Sapin V. Metabolism of retinol during mammal ian pl ac ent al and embryonic dev elopment. Vitam Horm. 2007;75: 97-115.
  • Muto Y, Moriw aki H, Ninomiya M, Adachi S, Saito A, Takas aki KT, et al. Prev ention of seco nd primary tumors by an acyclic r etino id, polypr eno ic ac id, in patients with hepatocellular carcinoma. N Engl J M ed 1996; 334(24):1561- 7.
  • Newsome PN, Beldon I , Moussa Y, Delahooke TE, Poulopoulos G, Hayes PC, et al. Low serum ret inol l evels are associated with hepatocellular carcinoma in patients with chronic liver disease. Aliment Pharmacol Ther 2000;14:1295-301.
  • Oliveira CP, Kass ab P, Lopasso FP, Souza HP, Janis zewski M, Laurindo FR, et al. Protective effect of ascorbic acid in experimental gastr ic cancer: Reduction of oxidativ e stres. World J Gastroenterol 2003; 9(3):446-8.
  • Omay e ST, Turnbul JD, and Saulderlich H E. Ascorbic acid analysis . II. Determinat ion after der ivatio n with 2,4, dinitrophenlylhydazine, In: Select ed methods for the determinatio n of ascorbic ac id in animal cells, t issues and fluids. Meth Enz imol 1979; 62:7- 8.
  • Palli D, Russo A, Saieva C, Salvini S, Amorosi A, Dec arli A. Diet ary and famil ial determinants of 10-year survival among pat ients with gastric carcinoma. Cancer 2000; 89(6): 1205-13.
  • Qiu JL, Chen K, Zheng JN, Wang JY, Zhang LJ, Sui LM. Nutritional factors and gastric cancer in Zhoushan Islands, China. World J Gastroenterol 2005;11(28): 4311-6.
  • Schor ah CJ, Sob al a GM, Sanderson M, Collis N, Pr imrose JN. Gastric juice ascorbik acid: Effects of disease and impl icat ions for gastric carcinogenesis . Am J Clin Nutr 1991; 53(1):287- 93.
  • Singh P, Kapil U, Shukla NK, Deo S, Dwiv edi SN. Assoc iat ion between br east cancer and vitamin C, vitamin E and selenium lev els: results of a case-control study in India. Asian Pac J Cancer Prev 2005;6(2):177-80.
  • Sommer A. Vitamin A deficiency and clinical disease: An historical overview. J Nutr 2008; 138:1835-9. Stahelin HB, Gey KF, Eichholzer M and Ludin E. -carotene and cancer prev ention: The Basel Study. Am J Clin Nutr l99l; 53: 265-9.
  • Sun YQ, Girgensone I, Leanderson P, Peterrsson F, Borch K. Effects of antioxidant vitamin supplements on hel icobacter pylori-induced gastritis in mongol ian gerbils. Helicobacter 2005;10(1):33- 42.
  • Suzuki S, and Katoh N. A simple and cheap methods forme as using serum vitamin A in cattle using only a spectrophometer . Jpn J Vet Sci 1990; 52(6): 1281-3.
  • Terry P, Lager gren J, Ye W, Nyre´N O, and Wolk A. Antioxidants and cancers of the esophagus and gastric cardia. Int . J Cancer 2000; 87:750-4.
  • Türkdoğan KM, T ester eci H, Kahraman T, Tuncer İ, Algün E Yörük İH. Mide ve özefagus kanserlerinde serum ve dokuda A ve E vitamini düz eyler i. Türk J. Gastroent erol 1996; 7:327-30.
  • Villacorta L, Azzi A, Zingg JM. Regulatory role of vitamins E and C on extracellular matrix components of the vascular system. Mol Aspects Med 2007; 28:507-37.
  • Waring AJ, Schorah CJ. Transport of ascorbic acid in gastric epithelial cells in vitro. Clin Chim Acta 1998;275:137-49.
  • Wu Q, Chen YQ, Chen ZM, Chen F, Su WJ. Effects of retinoic acid on metastasis and its related proteins in gastric canc er cel ls in vivo and in vitro . Acta Pharmacol Sin 2002; 23(9): 835-41.
  • Yıldırım M, Gündüz Ş, Demirpençe Ö, Kaya V. Role of Vitamin C in gastritis and gastric cancer. J Clin Anal Med 2014; 5(143):240-3.
  • Yılmaz Ö, Dursun H , Keleş S, Yılmaz A, Okcu N. Pl asma v itamin A and E levels in patients with gastroesophageal cancer in East ern Anatolia. Turk J Med Sci 2010;40(1):115-9.
  • Zhang L, Blot WJ, You WC, Chang YS, Liu XQ, Kneller RW, et al. Serum micronutrients in relation to pr ecancerous gastric lesions. lnt J Cancer 1994;56:650-4.

Serum vitamin C, Beta-carotene and retinol levels in liver and gastrointestinal systems diseases

Yıl 2018, Cilt: 11 Sayı: 2, 6 - 10, 15.12.2018

Öz

Gastrointestinal system diseases
are important causes of morbidity and mortality worldwide. Vita
min C,
b-carotene and retinol, which have antioxidant
properties, play an important role in the prevention of lipid peroxidation and free radical development in diseases of the gastrointestinal tract and
cancers. The aim of this
study was to evaluate the relationship between serum levels of vitamin C,
b-carotene and retinol
with ulcers, cirrhosis, esophagus and
stomach cancer diseases. In this study,
vitamin C,
b-
carotene and retinol levels were
evaluated in the serum of 35 ulcers, 40 esophageal
cancer, 30 gastric cancer, 25 liver cirrhosis patients and 50 healthy individuals. Vita mins were analyzed
spectrophotometrically. Comparison of serum vitamin
C levels of the patient groups with the
control group, shows a
statistically significant decrease in ulcerative patients and increase in esophageal cancer
patients (p<0.05). No statistically
significant difference was found in vitamin C levels in patients with gastric cancer and cirrhosis
(p>0.05).
b-carotene and retinol
levels were high in patients with ulcers, lower in patients with esophagus
and cirrhosis (p<0.05). Serum
b-carotene and retinol levels were not statistically significant in patients with gastric cancer (p>0.05).
b-carotene and retinol
decreased significantly in the esophagus-stomach
cancers and liver cirrhosis whereas an increase in vitamin C was observed. We believe that our research
will provide useful information for
incorporating antioxidant agents into the  diet. For this purpose, diets rich in antioxidant vitamins can play a
protective role in the prevention and progression of these diseases.

Kaynakça

  • Abnet CC, Qiao YL, Davsey SM, Buckman DW, Yang CS, Blot WJ, et al. Prospective study of serum retinol, beta-carotene, betacryptoxanthin, and lutein/z eaxant hin and esophageal and gastr ic cancers in China. Canc er Causes Control 2003; 14(7):645- 55.
  • Aditi A, and Gr aham DY. Vitamin C, gastr itis, and gastric disease: A historical review and update. Dig Dis Sci 2012; 57(10):2504-15.
  • Akkuş İ. Serbest Radikaller ve Fizyopatolojik Etkileri. Kony a, Mimoza Yayınl arı,1995. Alcant ara EN, Speckmann EW. Diet, nutrition, and cancer. Am J Clin Nutr 1976;29: 1035-47.
  • Almushatat AS, Tavlar D, McArdle PA, Williamson C, Sattar N, O’r eil ly DS, et al. Vitamin antio xidant , lipid peroxidat ion and the systemic inflammatory response in patients with prostate cancer. Int J Cancer 2005;118(4),1051-3.
  • Azevedo LF, Salgueiro LF, Claro R, Teixeir a-Pinto A, Costa- Pereira A. Diet and gastric cancer in Portugal-a multiv ariate model. Eur J Cancer Prev 1999;8(1):41- 8.
  • Bollag W, Holdener EE. Retinoids in cancer prev ention and therapy. Ann Oncol. 1992; 3(7):513-26. Chamras H, B arsky SH, Ardashian A, Nav asartian D, H eber D, Glaspy JA. Nov el interact ions of vit amin-E and estrogen in breast cancer. Nutr Cancer 2005;52(1), 43–8.
  • Dündar Y, Aslan R. H ekimlikte Oksidatif Stres ve Antioksidanlar , Afyon. Afyon Kocatepe Üniversit esi Yayınl arı, 2000.
  • Dursun H, Bilici M, Uyanık A, Okcu N, Akyüz M. Antioxidant enzyme activities and lipid peroxidatio n lev els in erythrocytes of patients with oesophageal and gastric canc er. J I nter Med Res 2006; 34: 193-9.
  • Fu Y, Yang G, Zhu F, Peng C, Li W, Li H, et al. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulat ing Src-dep endent caspas e-7 phosphorylation. Cell Death Dis. 2014; 5(1):983.
  • Goodman GE, Alberts DS, Meyskens FL. Retinol, vitamins, and canc er prev ention: 25 years of l earning and r el ear ning. J Clin Oncol 2008;26: 5495-6.
  • Halliw ell B. Antioxidants and human disease: A gener al introduct ion. Nutr Rev 1997;55: 44-52.
  • Ito Y, Kurata M, Hioki R, Suzuki K, Ochiai J, Aoki K. Cancer mortality and s erum levels of carotenoids, r etino l, and tokopherol: A population-based follow-up study of inhabit ants of a rur al area of Japan. Asian Pac J Cancer Prev 2005;6(1):10- 5.
  • Jenab M, Salvini S, Gils CHV, Brustad M, Shaky a-Shrestha S, Buijsse B, et al. Dietary intakes of r etinol, -carotene, vitamin D and vitamin E in the European Prospective investigatio n into Cancer and Nutrit ion cohort. Eur J Clin Nutr 2009;63:150-78.
  • Marceau G, Gallot D, Lemery D, Sapin V. Metabolism of retinol during mammal ian pl ac ent al and embryonic dev elopment. Vitam Horm. 2007;75: 97-115.
  • Muto Y, Moriw aki H, Ninomiya M, Adachi S, Saito A, Takas aki KT, et al. Prev ention of seco nd primary tumors by an acyclic r etino id, polypr eno ic ac id, in patients with hepatocellular carcinoma. N Engl J M ed 1996; 334(24):1561- 7.
  • Newsome PN, Beldon I , Moussa Y, Delahooke TE, Poulopoulos G, Hayes PC, et al. Low serum ret inol l evels are associated with hepatocellular carcinoma in patients with chronic liver disease. Aliment Pharmacol Ther 2000;14:1295-301.
  • Oliveira CP, Kass ab P, Lopasso FP, Souza HP, Janis zewski M, Laurindo FR, et al. Protective effect of ascorbic acid in experimental gastr ic cancer: Reduction of oxidativ e stres. World J Gastroenterol 2003; 9(3):446-8.
  • Omay e ST, Turnbul JD, and Saulderlich H E. Ascorbic acid analysis . II. Determinat ion after der ivatio n with 2,4, dinitrophenlylhydazine, In: Select ed methods for the determinatio n of ascorbic ac id in animal cells, t issues and fluids. Meth Enz imol 1979; 62:7- 8.
  • Palli D, Russo A, Saieva C, Salvini S, Amorosi A, Dec arli A. Diet ary and famil ial determinants of 10-year survival among pat ients with gastric carcinoma. Cancer 2000; 89(6): 1205-13.
  • Qiu JL, Chen K, Zheng JN, Wang JY, Zhang LJ, Sui LM. Nutritional factors and gastric cancer in Zhoushan Islands, China. World J Gastroenterol 2005;11(28): 4311-6.
  • Schor ah CJ, Sob al a GM, Sanderson M, Collis N, Pr imrose JN. Gastric juice ascorbik acid: Effects of disease and impl icat ions for gastric carcinogenesis . Am J Clin Nutr 1991; 53(1):287- 93.
  • Singh P, Kapil U, Shukla NK, Deo S, Dwiv edi SN. Assoc iat ion between br east cancer and vitamin C, vitamin E and selenium lev els: results of a case-control study in India. Asian Pac J Cancer Prev 2005;6(2):177-80.
  • Sommer A. Vitamin A deficiency and clinical disease: An historical overview. J Nutr 2008; 138:1835-9. Stahelin HB, Gey KF, Eichholzer M and Ludin E. -carotene and cancer prev ention: The Basel Study. Am J Clin Nutr l99l; 53: 265-9.
  • Sun YQ, Girgensone I, Leanderson P, Peterrsson F, Borch K. Effects of antioxidant vitamin supplements on hel icobacter pylori-induced gastritis in mongol ian gerbils. Helicobacter 2005;10(1):33- 42.
  • Suzuki S, and Katoh N. A simple and cheap methods forme as using serum vitamin A in cattle using only a spectrophometer . Jpn J Vet Sci 1990; 52(6): 1281-3.
  • Terry P, Lager gren J, Ye W, Nyre´N O, and Wolk A. Antioxidants and cancers of the esophagus and gastric cardia. Int . J Cancer 2000; 87:750-4.
  • Türkdoğan KM, T ester eci H, Kahraman T, Tuncer İ, Algün E Yörük İH. Mide ve özefagus kanserlerinde serum ve dokuda A ve E vitamini düz eyler i. Türk J. Gastroent erol 1996; 7:327-30.
  • Villacorta L, Azzi A, Zingg JM. Regulatory role of vitamins E and C on extracellular matrix components of the vascular system. Mol Aspects Med 2007; 28:507-37.
  • Waring AJ, Schorah CJ. Transport of ascorbic acid in gastric epithelial cells in vitro. Clin Chim Acta 1998;275:137-49.
  • Wu Q, Chen YQ, Chen ZM, Chen F, Su WJ. Effects of retinoic acid on metastasis and its related proteins in gastric canc er cel ls in vivo and in vitro . Acta Pharmacol Sin 2002; 23(9): 835-41.
  • Yıldırım M, Gündüz Ş, Demirpençe Ö, Kaya V. Role of Vitamin C in gastritis and gastric cancer. J Clin Anal Med 2014; 5(143):240-3.
  • Yılmaz Ö, Dursun H , Keleş S, Yılmaz A, Okcu N. Pl asma v itamin A and E levels in patients with gastroesophageal cancer in East ern Anatolia. Turk J Med Sci 2010;40(1):115-9.
  • Zhang L, Blot WJ, You WC, Chang YS, Liu XQ, Kneller RW, et al. Serum micronutrients in relation to pr ecancerous gastric lesions. lnt J Cancer 1994;56:650-4.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırma Makaleleri
Yazarlar

Tahir Kahraman

Mehmet Berköz Bu kişi benim

Ramazan Üstün

M. Kürşat Türkdoğan Bu kişi benim

Yayımlanma Tarihi 15 Aralık 2018
Gönderilme Tarihi 11 Ağustos 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 11 Sayı: 2

Kaynak Göster

APA Kahraman, T., Berköz, M., Üstün, R., Türkdoğan, M. K. (2018). KARACİĞER VE GASTROİNTESTİNAL SİSTEM HASTALIKLARINDA SER UM C VİTAMİNİ, Beta -KAROTEN VE RETİNOL DÜZEYLERİ. Van Sağlık Bilimleri Dergisi, 11(2), 6-10.

ISSN 

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