Kobaylarda Nemli ve Kuru Ortamın Yara iyileşmesindeki Etkilerinin Araştırılması Üzerine Deneysel Çalışmalar

Yıl 1995, Cilt: 1 Sayı: 2, 50 - 57, 06.11.1995

Burhanettin Olcay Atilla Kaya Hasan Bilgili Yılmaz Aydın

Öz

Bu
çalışmada kobaylar üzerinde yara modellerinde nemli ve kuru ortamın,
yara iyileşmesi üzerindeki rolü araştırıldı. Nemli ortam oluşturmak için steril
naylon veya transparan, adheziv, oksijen ve buhar geçirgen poliüretan film;
kuru ortam oluşturmak için de steril gazlı bez kullanıldı. Nemli yaralarda,
kuru yaralara göre yara kontraksiyonunun, epitelizasyonun, konnektif doku
rejenerasyonunun, daha hızlı oluştuğu tespit edildi. Steril naylon ve
poliüretan film uygulanan yaralardaki makroskopik ve histopatolojik iyileşme
modellerinin birbiri ile benzerlik gösterdiği dikkati çekti. Ancak steril
naylon uygulanan yaralarda maserasyon ve enfeksiyon gözlenirken, poliüretan
film uygulananlarda benzer bulgular görülmedi.

Anahtar Kelimeler

Kobay, Yara iyileşmesi, Nemli ortam, Kuru ortam

The Experimental Study in Mice on the Effects of Moist and Dry Condition on Wound Healing

Öz

The aim of our study was to
assess the effects of moist and dry conditions on ıvound healing in mice. Moist
condition ıvas provided by sterile nylon or transparent, adherent polyurethane
film that transmits water vapor and oxygen. Dry condition ıvas provided by
sterile gauze. In moist ıvound when compared ıvith dry ıvounds, ıvound
contraction, epithelization and connective tissue regeneration ıvere faster.
Thegross and histological ıvound healing models ıvere similar in ıvounds
dressed ıvith steril nylon and polyurethan film. Maceration and infection ıvere
observed in ıvounds dressed ıvith sterile nylon. These findings were not seen
in polyurethane film

Kaynakça

• BlankTH: What are the fımctions of skin lost in burn injury that affect short-and long-term recoverv J Traunıa. 24:10.1984.
• Winter GD: Formation of the scab and the rate of epitelization of superfıcial wounds in the skin of the young domestic pig.Nature, 193:293-4, 1962.
• Winte GD. Scales JT: Effect of air and dressings of the surface of a wound.Nature, 197:91-2,1963. Hinıan CD,Maibach H: Effect of air exposure and occlusion on experimental human skin \vounds.Nature. 200:377-8, 1963.
• Winter GD: Epidermal regeneration studied in the domestic pic.in: Maibach HL, Rovee DT, eds. Epidermal wound healing.Chigago: Year Book Medical Publishersînc.,71-112,1972.
• Falanga V: Occlusive vvound dressing: Why, when, which. ArcDennatol, 124:872-7, 1988.
• Eaglstein WH. Davis SC,Mehle AL, Mertz PM: Optımal use of an occlusive dressing to enhance healing. ArcDennatol, 124:392-5,1988.
• Breuing K, Eriksson E, Liu P, Miller DR: Healing of partial thickness porcine skin wounds in a liquid environment. J Surg Research, 52:50-8,1992.
• Hammar H: Wound healing. Int J Dermatol, 32(1): 6-15, 1993.
• Siebert JW, Burd AR, McCarthy JG. Weinzweig J and Erlich HP: Fctal wouııd healing: Abiochemical studv of scar-less healing. Plast Reconstr Surg, 85(4):495,1990.
• Depalma RL, Krummel TM, Durham LI, Michna BA, Thomas BL, Nelson JM and Diegelmann RF: Characterization and quantitaioıı of wound matrix in the fetalrabbit. Matrix, 9:224,1989.
• Eaglstein WH, Mertz PM: New method for assessing epidermal vvound healing: The effects of triamcinolone acetonide and polyethilenefilm occlusion. J InvestDermatol, 71: 382-4,1978.
• Hien NT, Prawer SE, Katz. HI: Facilitated vvound healing using transparent film dressing follovving mohs micrographic surgery. Arc Dermatol, 124:903-6,1988.
• Alvarez OM. Mertz PM, Eaglstein WH: The effect of occlusive dressing on collagen synthesis and re- epitelisation in superfıcial wounds. J Surg Research. 35:142- 8,1983.
• Ellion GR. Hamnıer AH, Fasbender MJ, Classen E: Wound healing using human skin transplant on to athymic nüde nıice: A comparison of 'dry’ and vmoisf vvound healing. Agentsand Actions. 32(1/2): 122-4, 1991.
• Carrigo TJ, Mehrof Al, Cohen IK: Biology of vvound healing. America: Surgical Clinics of North, 64(4):721-31,1984.
• PeacockEEJr, Cohen IK: Wound healing. General principles of plastic surgery. İn: Mc Carthy JG, 5th ed. Philadelphia: WB Saunders Company, 161-77. 1990.
• Dyson M, Young SR, Lynch JA, Lang S: Comparison of the effects of moist and dry conditions on the process of angiogenesis during dermal repair. J Invest Dermatol, 99(6): 729-33,1992.
• Dyson M, Young S, Pendle C, Webster DE Long SM: Conıparison of the effects of moist and dry conditions ondermal repair. JlnvestDermatol, 91(5):434-9,1988.
• Mertz PM, Eaglstein WH: The effect of a semiocclusive dressing on the microbial population in superfıcialwounds.ArcSurg, 119:287-9,1984.
• Krizek TJ, RobsenMC, Kho E: Bacterial growth and skin graft survival. SurgForum,18: 518-9,1967.