Serbest Radikal Türlerinin Membran Lipid Peroksidasyonuna Etkileri ve Hücresel Antioksidan Savunma

Yıl 1995, Cilt: 1 Sayı: 2, 137 - 142, 06.11.1995

Recep Aslan Mehmet Ramazan Şekeroğlu Fahir Bayıroğlu

Öz

Bu
makale, son yıllarda dikkatlerin üzerinde yoğunlaştığı radikaller ve
antioksidanların neler olduğu, oluşumları, muhtemel etki mekanizmaları ve
kaynaklarının tartışılmasını içermektedir. Ayrıca temel radikal reaksiyonları
sonucu oluşan ürün tipleri tanımlanmaktadır. Aerobik canlılar oksijen
metabolizması sırasında oksijen türevi serbest radikal üretimine karşılık bu
radikallerin oluşturabileceği riskleri önlemeye yönelik enzimler ve kimyasallar
taşırlar Makale ayrıca yaygın radikal kaynaklan ve antioksidan savunma
sistemlerini de ele almaktadır.

Anahtar Kelimeler

Lipid peroksidasyonu, Antioksidanlar, Hücre membranı

Effect of Free Radical Species on Membrane Lipid Peroxidation and Cellular Antioxidant Defense

Öz

In this article free radicals and antioxidants uıhich have become focus of attention with regard to their formation and mechanisms in recent years are discussed. Aerobic organismsgenerale oxygen derivated free radicals during oxygen metabolism, and they carry antioxidan Chemicals and enzymes which prevent or reduce the effect of these radicals. The more common sources of free radicals are described in the article and the methods used by cells to protect themselves from free radical damage, are described.

Anahtar Kelimeler

Lipid peroxidation, Antioxidants, Cell membrane

Kaynakça

• Packer L., Landvik S.: Vitamin E in biological Systems, antioxidant in therapy and preventive medicine, 262,93-103,1990.
• Harris E.D.: Regulationof antioxidantenzymes, FasebJ. 6,2675-83,1992.
• Di Mascio P, Murphy M.E., Sies H.: Antioxidant defense systems: The role of caretenoids, tochopherols and thiols, Am. J. Clin. Nurtr., 53,194,1991.
• Clarkson P.M.: Antioxidants and physical performance, critical reviews in food Science and nutrition, 35,1-2,131-41,1995.
• Dinçer C.:Egzersizde oluşan lipid peroksidasyonu ve E vitamininin koruyucu etkisi, Spor ve Tıp, 7-8,20-23, 1995.
• Thomas M.J.: The role of free radicals and antioxidants: How do we know that they are vvorking?, Critical Reviews in Food Sci. and Nutr. 35,21-29,1995.
• Pal Yu B.: Cellular defenses against damage from reactive species. Physiological Reviews, 74,1,139-162,1994.
• Akkuş İ.: Serbest Radikaller ve Fizyopatolojik Etkileri, 1 .baskı. Mimoza Yayınlan, Konya, 1995. CheesemanK.H., SlaterT.F.: Anintroductionto freeradicalbiochemistry, Br. Med. Bull.,49,3,479-481,1993.
• Hallivvell B., Murcia M.A., Chirico S., Auroma O.I.: Free radicals and antioxidants in food and in vivo: What they do and how they work. Critical Reviews in Food and Nutrition, 35, 1-2,7-20,1995.
• Erenel G., Erbaş D., Arıcıoğlu A.: Serbest Radikaller ve Antioksidan Sistemler, Gazi Tıp Dergisi, 3, 243-250,1992.
• Lehninger A.: Principles of Biochemistry, Worth Publishers Inc., 46-220, New York, 1982.
• McCord J.M., Keele B.B., Fridovvich I.: An enzyme based theory of obligate anaerobiosis: The physiological function of superoxide dismutase, Proc. Nat. Acad. Sci., 68,1024-1027,1981.
• Klebanoff S.J.: Oxygen metabolism and toxic propertiesofphagocytes, Ann. Int. Med., 93,480-489,1980.
• Bast A., Haenen G.R.M., Doelman C.J.A.: Oxidants and antioxidants: State of Art, Am. J. Med., 91,3, 2-13,1991.
• Sies H.: Oxidative stress: Frombasic research to clinical application, Am. J. Med., 91,3, 31-38,1991.
• Halliwell B.: Rective oxygen species in living systems: Source, Biochemistry and role in human disease, Am. J. Med., 91,3,14-21,1991.
• Freeman B.A., Crapo. J.D.: Biology ofdisease; Free radicals and tissue injury., Lab. Invest, 47, 5, 412- 424,1982.
• HalliwellB., GutteridgeJ.M. :Role of free radicals and catalytic metal ions in human disease: An Overview, Methods, Enzymol., 186,1-8,1990.
• Freeman B. A., Crapo J.D.: Free radicals and tissue injury, Lab. Invest., 47,412-426,1982.
• Churc D.F., Pryor W.A.: Free radical chemistry of cigarette and its toxicological implications, Environ. Health. Perspect., 64,111-17,1985.
• Halliwell B.: Free radicals, reactive oxygen species, and human disease: A Critical Evaluation with Special Reference to Atherosclerosis, Br. J. Exp. Pathol., 70,737-757,1989.
• Halliwell B.: Free radicals, antioxidants and human disease: Curiosity, cause or consequence?, Lancet, 344,721-724,1994.
• HalliwellB., Gutteridge J.M.: Lipidperoxidation, oxygen radicals, celi damage and antioxidant therapy, Lancet, 23,1396-1398,1984.
• Andrews V.R., WinyardPG., Morris C.J.,Blake Yüzüncü Yıl Üniversitesi Sağlık Bilimleri Derg. 2:137-142,1995 D.R.. Free radicals in inflamation, Br. Med. Bull., 49, 3,506- 522,1993.
• Valenzuela A.: The biological signifıcance of malondialdehyde determination in the assessment of tissue oxidative stress, Life Scien., 48, 301-309,1990.
• Packer L., Landvik S.: Vitamin E in biological systems, antioxidant in therapy and preventive medicine, 262,93-103,1990.
• Lunec J., Blake D.: OxygenFreeRadicals: Their Relevance to Disease Processes, Editör, Cohen, R.D., Balliere-Tindall, London, 189-212,1990.
• Flohe, L. and Otting, F.: Superoxide dismutase assays,MethodsEnzymol., 105,93-104,1984