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Sigara Kullanan Bireylerde Farklı Teşhise Sahip Dişlerin Adenozin Deaminaz ve Katalaz Seviyelerinin Karşılaştırılması

Yıl 2019, Cilt: 12 Sayı: 2, 1 - 7, 29.12.2019

Öz

Amaç: Periodontitis,
periodontal dokularda ve DOS’ta oksidatif hasar belirteçlerinde artış ile
karakterize bir hastalıktır. Katalaz (KAT) antioksidan, Adenozin deaminaz (ADA)
ise lenfosit çoğalması/farklılaşması ile ilişkili bir enzimdir. Bu çalışmanın
amacı periodontal açıdan umutsuz dişleri bulunan ve çekim kararı verilen dişler
ile aynı bireyde bulunan periodontitisli ve gingivitisli dişlerin periodontal
klinik parametreleri ve dişeti oluğu sıvısındaki (DOS) ADA ve KAT seviyelerinin
karşılaştırılmasıdır. Bu çalışma literatürde ADA’ nın DOS’ta değerlendirildiği
ilk çalışmadır. 

Gereç-Yöntem: Periodontoloji
kliniğine periodontal hastalık şikayeti ile başvuran ve günde 1 paket sigara
içtiğini belirten 14 hasta bu çalışmaya dahil edilmiştir. Hastaların tüm ağız
ve her bir grup için ayrı ayrı periodontal klinik parametreleri kaydedilmiştir.
Her hastadan faz 1 tedavi öncesi periodontal olarak umutsuz olan diş (grup-1),
periodontitis (grup-2) ve gingivitis teşhisi konulan dişlerinden (grup-3) DOS
örneği alınmıştır. Alınan DOS örneklerinde ADA ve KAT seviyeleri
spektrofotometrik yöntem kullanılarak ölçülmüştür.

 Bulgular: Bu çalışmada periodontal
hastalık şiddeti arttıkça KAT seviyesinde azalma, ADA seviyesinde ise artış
olduğu gözlenmiştir. Üç grup arasında ADA ve KAT seviyesinin istatistiksel
olarak anlamlı derecede farklı olduğu belirlenmiştir (p<0.05).
Sondlanan cep derinliği açısından grup-1
ile grup-3 ve grup-2 ile grup 3 arasındaki fark istatistiksel olarak anlamlı
bulunmuştur (p<0.05).











Sonuç: ADA’nın sigara içen
bireylerde hücre aracılı immün yanıttaki rolünden dolayı önemli bir aktivite
belirteci olarak kullanılabileceği öngörülmektedir. ADA’nın periodontal
hastalık etiyopatogenezindeki öneminin tamamiyle anlaşılması için daha fazla
sayıda klinik araştırmaya gerek olduğu düşünülmektedir.

Kaynakça

  • Al-Shammari KF. Risk indicators for tooth loss due to periodontal disease. J Periodontol. 2005;76(11):1910-8.
  • Al-Shammari K, Al-Ansari JM, Al-Melh MA, Al-Khabbaz AK. Reasons for tooth extraction in Kuwait. Med Princ Pract. 2006;15:417-22.
  • Akhter R, Hassan NM, Aida J, Zaman KU, Morita M. Risk indicators for tooth loss due to caries and periodontal disease in recipients of free dental treatment in an adult population in Bangladesh. Oral Health Prev Dent. 2008;6(3):199-207.
  • Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE. Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol. 2003;171(10):5562–70.
  • Anand P, Kamath KP, Nair B. Trends in extraction of permanent teeth in private dental practices in Kerala state, India. J Contemp Dent Pract. 2010;11(3):41-8.Ayrancı AB. Periodontal hastalik nedeniyle kaybedilen dişlerin tüm diş kayiplari içerisindeki oraninin saptanmasi. [Doktora Tezi]. Gazi Üniversitesi Sağlik Bilimleri Enstitüsü Periodontoloji Anabilim Dali. 2012.
  • Byahatti SM. Reasons for extraction in a group of Libyan patients. Int Dent J. 2011;61(4):199-203.
  • Burt B. Epidemiology of periodontal diseases. J Periodontol. 2005;76(8):1406-19.
  • Chrysanthakopoulos NA. Reasons for extraction of permanent teeth in Greece: a five-year follow-up study. Int Dent J. 2011;61(1):19-24.
  • Danielson OE. Frequency, causes and pattern of adult tooth extraction in a Nigerian rural health facility. Odontostomatol Trop. 2011;34(134):5-10.Day BJ. Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 2009;77(3):285–96.
  • Dahiya P, Kamal R, Gupta R, Bhardwaj R, Chaudhary K, Kaur S. Reactive oxygen species in periodontitis. J Indian Soc Periodontol. 2013;17(4):411–6.
  • Dikensoy O, Namiduru M, Hocaoglu S, Ikidag B, Filiz A. Increased Pleural Fluid Adenosine Deaminase in Brucellosis Is Difficult to Differentiate from Tuberculosis. Respiration. 2002;69(6):556–9. Doğan A. Sigaranın periodontal hastalık etyolojisindeki rolü. GÜ Dişhek Fak Der. 1999;16(2):49-55.
  • Esan T, Olusile AO, Ojo MA, Udoye CI, Oziegbe EO, Olasoji HO. Tooth loss among Nigerians treated in teaching hospitals: a national pilot study. J Contemp Dent Pract. 2010;11(5):17-24.
  • Glockmann E, Panzner KD, Huhn P, Sigusch BW, Glockmann K. Ursachen des Zahnverlustes in Deutschland – Dokumentation einer bundesweiten Erhebung (2007). IDZ-Information. 2011;2:3-30.
  • Hameed AKM, El-Said TO, Askar HY, ElKady BA. Performance of serum adenosine deaminase in measuring disease activity in rheumatoid arthritis patients. The Egyptian Rheumatologist. 2019;41(2);81-5
  • Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30–44.
  • Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, Lohinai Z, Southan, GJ, Salzman AL, Szabo C. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol. 2000:164;1013–9.
  • Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000. 2007;44:178-94.
  • Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. 1993;261(5120):466–9.
  • Kowalczyk E, Kopff M, Kowalski J, Kopff A, Mikhailidis DP, Barylski M, Banach M. Effect of cardiovascular drugs on adenosine deaminase activity. Angiology. 2009;59(6):740-4.
  • Lesolang R, Motloba DP, Lalloo R. Patterns and reasons for tooth extraction at the Winterveldt Clinic: 1998-2002. SADJ. 2009;64(5):214-15.
  • Liao Y-J, Wu C-Y, Lee S-W, Lee C-L, Yang S-S, Chang C-S, et al. Adenosine deaminase activity in tuberculous peritonitis among patients with underlying liver cirrhosis. World J Gastroenterol. 2012;18(37):5260–5.
  • Luzzi LIT, Greghi SLA, Passanezi E, Santana ACP, Lauris JRP, Cestari TM. Evaluation of clinical periodontal conditions in smokers and non-smokers. J Appl Oral Sci. 2007;15(6):512-17.
  • Matés JM, Sánchez-Jiménez F. Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci. 1999;4:339–45.
  • McCaul L, Jenkins WMM, Kay EJ. The reasons for extraction of permanent teeth in Scotland: a 15-year follow-up study. Br Dent J. 2001;190(12):658-62.
  • Mishra OP, Gupta BL, Ali Z, Nath G, Chandra L. Adenosine deaminase activity in typhoid fever. Indian Pediatrics 1994;31:1379–84.
  • Ong G. Periodontal reasons for tooth loss in an Asian population. J Periodontol 1996;23(4):307-9.
  • Okur E, Inanc F, Yildirim I, Kilinc M, Kilic MA. Malondialdehyde Level and Adenosine Deaminase Activity in Nasal Polyps. Otolaryngol Neck Surg. 2006;134(1):37–40.
  • Ojima M, Hanioka T, Tanaka K, Aoyama H. Cigarette smoking and tooth loss experience among young adults: a national record linkage study. BMC Public Health. 2007;7:313.
  • Rai B, Kaur J, Jacobs R, Anand SC. Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue. Clin Oral Invest. 2011;15:347–9.
  • Saghiri R, Ghashghai N, Movaseghi S, Poursharifi P, Jalilfar S, Bidhendi MA, et al. Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern. Rheumatol Int. 2012;32(6):1633–8.
  • Sarhat ER, Hamad AI, Mohammaed IJ, Sarhat TR. The Effect of Diabetic Patients with Chronic Periodontitis on Serum Paraoxonase, Adenosine Deaminase. Mustansiria Dent J. 2018;15:130-4.
  • Spalj S, Plancak D, Jurić H, Pavelić B, Bosnjak A. Reasons for extraction of permanent teeth in urban and rural populations of Croatia. Coll Antropol. 2004;28(2):833-9.Taani DSMQ. Periodontal reasons for tooth extraction in an adult population in Jordan. J Oral Rehabil. 2003;30:110–112. Thomé GR, Mazzanti CM, Ahmed M, Corrêa M, Spanevello RM, Maldonado PA, Luchese C, Cargnelutti D, Morsch VM, Duarte MM, Fiorenza AM, Nogueira CW, De Bona KS, Moretto MB, Da Luz SC, Mazzanti A, Schetinger MR. Activity of ectonucleotidases and adenosine deaminase in rats exposed to cigarette smoke. 2009;21(11):906-12.
  • Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018:89;159–72.
  • Xia Y, Khatchikian G, Zweier JL. Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart. J Biol Chem. 1996;271(17):10096–102.
Yıl 2019, Cilt: 12 Sayı: 2, 1 - 7, 29.12.2019

Öz

Kaynakça

  • Al-Shammari KF. Risk indicators for tooth loss due to periodontal disease. J Periodontol. 2005;76(11):1910-8.
  • Al-Shammari K, Al-Ansari JM, Al-Melh MA, Al-Khabbaz AK. Reasons for tooth extraction in Kuwait. Med Princ Pract. 2006;15:417-22.
  • Akhter R, Hassan NM, Aida J, Zaman KU, Morita M. Risk indicators for tooth loss due to caries and periodontal disease in recipients of free dental treatment in an adult population in Bangladesh. Oral Health Prev Dent. 2008;6(3):199-207.
  • Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE. Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol. 2003;171(10):5562–70.
  • Anand P, Kamath KP, Nair B. Trends in extraction of permanent teeth in private dental practices in Kerala state, India. J Contemp Dent Pract. 2010;11(3):41-8.Ayrancı AB. Periodontal hastalik nedeniyle kaybedilen dişlerin tüm diş kayiplari içerisindeki oraninin saptanmasi. [Doktora Tezi]. Gazi Üniversitesi Sağlik Bilimleri Enstitüsü Periodontoloji Anabilim Dali. 2012.
  • Byahatti SM. Reasons for extraction in a group of Libyan patients. Int Dent J. 2011;61(4):199-203.
  • Burt B. Epidemiology of periodontal diseases. J Periodontol. 2005;76(8):1406-19.
  • Chrysanthakopoulos NA. Reasons for extraction of permanent teeth in Greece: a five-year follow-up study. Int Dent J. 2011;61(1):19-24.
  • Danielson OE. Frequency, causes and pattern of adult tooth extraction in a Nigerian rural health facility. Odontostomatol Trop. 2011;34(134):5-10.Day BJ. Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 2009;77(3):285–96.
  • Dahiya P, Kamal R, Gupta R, Bhardwaj R, Chaudhary K, Kaur S. Reactive oxygen species in periodontitis. J Indian Soc Periodontol. 2013;17(4):411–6.
  • Dikensoy O, Namiduru M, Hocaoglu S, Ikidag B, Filiz A. Increased Pleural Fluid Adenosine Deaminase in Brucellosis Is Difficult to Differentiate from Tuberculosis. Respiration. 2002;69(6):556–9. Doğan A. Sigaranın periodontal hastalık etyolojisindeki rolü. GÜ Dişhek Fak Der. 1999;16(2):49-55.
  • Esan T, Olusile AO, Ojo MA, Udoye CI, Oziegbe EO, Olasoji HO. Tooth loss among Nigerians treated in teaching hospitals: a national pilot study. J Contemp Dent Pract. 2010;11(5):17-24.
  • Glockmann E, Panzner KD, Huhn P, Sigusch BW, Glockmann K. Ursachen des Zahnverlustes in Deutschland – Dokumentation einer bundesweiten Erhebung (2007). IDZ-Information. 2011;2:3-30.
  • Hameed AKM, El-Said TO, Askar HY, ElKady BA. Performance of serum adenosine deaminase in measuring disease activity in rheumatoid arthritis patients. The Egyptian Rheumatologist. 2019;41(2);81-5
  • Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30–44.
  • Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, Lohinai Z, Southan, GJ, Salzman AL, Szabo C. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol. 2000:164;1013–9.
  • Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000. 2007;44:178-94.
  • Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. 1993;261(5120):466–9.
  • Kowalczyk E, Kopff M, Kowalski J, Kopff A, Mikhailidis DP, Barylski M, Banach M. Effect of cardiovascular drugs on adenosine deaminase activity. Angiology. 2009;59(6):740-4.
  • Lesolang R, Motloba DP, Lalloo R. Patterns and reasons for tooth extraction at the Winterveldt Clinic: 1998-2002. SADJ. 2009;64(5):214-15.
  • Liao Y-J, Wu C-Y, Lee S-W, Lee C-L, Yang S-S, Chang C-S, et al. Adenosine deaminase activity in tuberculous peritonitis among patients with underlying liver cirrhosis. World J Gastroenterol. 2012;18(37):5260–5.
  • Luzzi LIT, Greghi SLA, Passanezi E, Santana ACP, Lauris JRP, Cestari TM. Evaluation of clinical periodontal conditions in smokers and non-smokers. J Appl Oral Sci. 2007;15(6):512-17.
  • Matés JM, Sánchez-Jiménez F. Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci. 1999;4:339–45.
  • McCaul L, Jenkins WMM, Kay EJ. The reasons for extraction of permanent teeth in Scotland: a 15-year follow-up study. Br Dent J. 2001;190(12):658-62.
  • Mishra OP, Gupta BL, Ali Z, Nath G, Chandra L. Adenosine deaminase activity in typhoid fever. Indian Pediatrics 1994;31:1379–84.
  • Ong G. Periodontal reasons for tooth loss in an Asian population. J Periodontol 1996;23(4):307-9.
  • Okur E, Inanc F, Yildirim I, Kilinc M, Kilic MA. Malondialdehyde Level and Adenosine Deaminase Activity in Nasal Polyps. Otolaryngol Neck Surg. 2006;134(1):37–40.
  • Ojima M, Hanioka T, Tanaka K, Aoyama H. Cigarette smoking and tooth loss experience among young adults: a national record linkage study. BMC Public Health. 2007;7:313.
  • Rai B, Kaur J, Jacobs R, Anand SC. Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue. Clin Oral Invest. 2011;15:347–9.
  • Saghiri R, Ghashghai N, Movaseghi S, Poursharifi P, Jalilfar S, Bidhendi MA, et al. Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern. Rheumatol Int. 2012;32(6):1633–8.
  • Sarhat ER, Hamad AI, Mohammaed IJ, Sarhat TR. The Effect of Diabetic Patients with Chronic Periodontitis on Serum Paraoxonase, Adenosine Deaminase. Mustansiria Dent J. 2018;15:130-4.
  • Spalj S, Plancak D, Jurić H, Pavelić B, Bosnjak A. Reasons for extraction of permanent teeth in urban and rural populations of Croatia. Coll Antropol. 2004;28(2):833-9.Taani DSMQ. Periodontal reasons for tooth extraction in an adult population in Jordan. J Oral Rehabil. 2003;30:110–112. Thomé GR, Mazzanti CM, Ahmed M, Corrêa M, Spanevello RM, Maldonado PA, Luchese C, Cargnelutti D, Morsch VM, Duarte MM, Fiorenza AM, Nogueira CW, De Bona KS, Moretto MB, Da Luz SC, Mazzanti A, Schetinger MR. Activity of ectonucleotidases and adenosine deaminase in rats exposed to cigarette smoke. 2009;21(11):906-12.
  • Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018:89;159–72.
  • Xia Y, Khatchikian G, Zweier JL. Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart. J Biol Chem. 1996;271(17):10096–102.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Diş Hekimliği
Bölüm Orijinal Araştırma Makaleleri
Yazarlar

Hacer Şahin Aydınyurt 0000-0002-9521-9704

Cem Taşkın Bu kişi benim

Kübra Eskin Bu kişi benim

Yayımlanma Tarihi 29 Aralık 2019
Gönderilme Tarihi 18 Eylül 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 12 Sayı: 2

Kaynak Göster

APA Şahin Aydınyurt, H., Taşkın, C., & Eskin, K. (2019). Sigara Kullanan Bireylerde Farklı Teşhise Sahip Dişlerin Adenozin Deaminaz ve Katalaz Seviyelerinin Karşılaştırılması. Van Sağlık Bilimleri Dergisi, 12(2), 1-7.

ISSN 

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