Araştırma Makalesi
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Are there any changes in serum renal parameters in patients undergoing ESWL therapy?

Yıl 2022, Cilt: 15 Sayı: 2, 122 - 128, 31.08.2022
https://doi.org/10.52976/vansaglik.1035399

Öz

Purpose: The goal of this research was to explain the effects of ESWL on renal function (Extracorporeal Shock Wave Lithotripsy).
Materials and Methods: This study was carried out retrospectively between November 2019 and October 2020, with 50 adult patients scheduled to perform an ESWL treatment because of a diagnosis of kidney stone and to completed the study protocol. In all of these patients, there was no urogenital abnormality, and none had a solitary kidney. Patients' mean age was 37.2 (between 26 and 67 years of age). Of patients, 31 (62%) were male and 19 (38%) were female. Three ESWL sessions were carried out in the patients and the time between sessions was set at 7 days. The routines collected one day before the ESWL (Routine I) protocol were repeated one day after the first session (Routine II) and one day after the end of all ESWL (Routine III) sessions.
Results: There wasn’t any statistically significant difference among routines in terms of the ratio of serum electrolytes, serum creatinine, GFR and spot urine/protein.
Conclusion: The findings indicate that the renal function tests do not need to assess whether ESWL leads to a tubular functional dysfunction in patients when treating upper urinary system stone disease.
Keywords: Extracorporeal Shock Wave Lithotripsy (ESWL), renal stone, renal function and glomerular filtration rate (GFR)

Destekleyen Kurum

SBÜ Van Eğitim ve Araştırma Hastanesi

Proje Numarası

2021/05

Teşekkür

In Department of Urology, Health Sciences University Van Training and Research Hospital for many years, Extracorporeal Shock Wave Lithotripsy (ESWL) has been used to treatment of Urolithiasis. With this study, we aimed to estimate the possible side effects of ESWL on the group of patients with nephrolithiasis. We retrospectively investigated the effect of ESWL on kidney stones and discussed the subject by comparing it with the previous studies in the literature. For any information concerning this manuscript, please contact me preferably by e-mail at isbarlas89@gmail.com . Thank you for your consideration of this manuscript.

Kaynakça

  • 1. Akinci M, Esen T, Tellaloğlu S. Urinary Stone disease in Turkey : an updated epidemiological study . Eur Urol. 1991;20: 200-203.
  • 2. Turna B, Nazlı O. Beden dışı şok dalga ile taş kırma. Türk Üroloji Dergisi 2005;31: 229-235.
  • 3. Weichert-Jacobsen K, Scheidt M, Külkens C, Loch T. Morphological correlates of urinary enzyme loss after extracorporeal lithotripsy. Urol Res. 1997;25(4): 257-62.
  • 4. Weichert-Jacobsen K, Stöckle M, Loch T, Brüske T. Urinary leakage of tubular enzymes after shock wave lithotripsy. Eur Urol. 1998;33: 104-110.
  • 5. Gunasekaran S, Donovan JM, Chvapil M, Drach GW. Effects of extracorporeal shock wave lithotripsy on the structure and function of rabbit kidney. J Urol. 1989;141: 1250-1254.
  • 6. Preminger GM. Review: in vivo effects of extracorporeal shock wave lithotripsy: animal studies. J Endourol. 1993;7: 375-378.
  • 7. Evan AP, Willis LR, Connors B. Shock wave lithotripsy-induced renal injury. Am J Kidney Dis. 1991;17: 445-450.
  • 8. Karlsen SJ, Smevik B, Hovig T. Acute morphological changes in canine kidneys after exposure to extracorporeal shock waves. A light and electron microscopic study. Urol Res. 1991;19: 105-115.
  • 9. Willis LR, Evan AP, Connors BA. Shockwave lithotripsy: dose-related effects on renal structure, hemodynamics, and tubular function. J Endourol. 2005;19: 90-101.
  • 10. Connors BA, Evan AP, Willis LR. The effect of discharge voltage on renal injury and impairment caused by lithotripsy in the pig. J Am Soc Nephrol. 2000;11: 310-318.
  • 11. Evan AP, Connors BA, Pennington DJ. Renal disease potentiates the injury caused by SWL. J Endourol. 1999;13: 619-628.
  • 12. Connors BA, Evan AP, Willis LR. Renal nerves mediate changes in contralateral renal blood flow after extracorporeal shockwave lithotripsy. Nephron Physiol. 2003;95: 67-75.
  • 13. Evan AP, Willis LR, Lingeman JE. Renal trauma and the risk of long-term complications in shock wave lithotripsy. Nephron. 1998;78: 1-8.
  • 14. Willis LR, Evan AP, Connors BA. Effects of extracorporeal shock wave lithotripsy to one kidney on bilateral glomerular filtration rate and PAH clearance in minipigs. J Urol. 1996;156: 1502-1506.
  • 15. El-Nahas AR, Awad BA, El-Assmy AM, et al. Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients? BJU Int. 2013;111(4):666–671.
  • 16. Assimos DG, Boyce WH, Furr EG. Selective elevation of urinary enzyme levels after extracorporeal shock wave lithotripsy. J Urol. 1989;142: 687-690.
  • 17. Recker F, Hofmann W, Bex A, Tscholl R. Quantitative determination of urinary marker proteins: a model to detect intrarenal bioeffects after extracorporeal lithotripsy. J Urol. 1992;148: 1000-1006.
  • 18. Rutz-Danielczak A, Pupek-Musialik D, RaszejaWanic B. Effects of extracorporeal shock wave lithotripsy on renal function in patients with kidney stone disease. Nephron. 1998;79: 162-166.
  • 19. Karlsen SJ1, Berg KJ. Acute changes in kidney function following extracorporeal shock wave lithotripsy for renal stones. Br J Urol. 1991;67(3): 241-5.
  • 20. Ilgın N, Iftehar SA, Vural G, Bozkirli I,Gokcora N. Evaluatian of renal function following treatment with ESWL : the use of whole –kidney, parenchymal and pelvic transit times . Nucl Med commun . 1998;19(2): 155 -9
  • 21. Goel MC, Baserge NS, Babu RV, Sinha S, Kapoor R. Pediatric kidney : functional outcome after ESWL. J Urol 1996;155(6): 2044-6
  • 22. Gupta M, Bolton DM, Irby P, Hubner W, Wolf JS, Hattner RS, Stoller ML. The effect of newer generation lithotripsy upon renal function assessed by nuclear scintigraphy . J Urol 1995:154(3); 947-50
  • 23. Pienkny AJ, Streem SB. Simultaneous versus staged bilateral extracorporeal shock wave lithotripsy: long-term effect on renal function. J Urol. 1999;162: 1591-1593.
  • 24. Perry KT, Smith ND, Weiser AC. The efficacy and safety of synchronous bilateral extracorporeal shock wave lithotripsy. J Urol. 2000;164: 644-647.
  • 25. Sheir KZ, Gad HM. Prospective study of the effects of shock wave lithotripsy on renal function . role of post-shock wave lithotripsy obstruction Urology 2003;61(6): 1102-6
  • 26. Saxby MF. Effects of PNL and ESWL on renal function and prostaglandin excreation. Scand J Urol Nrphrol 1997;31(2): 141-4
  • 27. Cass AS. Renal function after bilateral ESWL . J Endourol 1994;8(6): 395-9
  • 28. Greenstein A, Matzkin H, Kaver I, Baron J, Braf Z. Short term effect of a new portable extracorporal lithotripter on renal function . J Lithotr Stone Dis . 1990 ;2(4): 298-301
  • 29. El-Assmy A, El Nahas, Hekal IA, Bardan M, Youssef RF, Sheir KZ. Long- term effects of ESWL on renal function : our experience with 156 patients with solitary kidney . J Urol 2008; 179(6): 2229-32
  • 30. Villányi KK, Székely JG, Farkas LM. Short-term changes in renal function after extracorporeal shock wave lithotripsy in children. J Urol. 2001;166: 222-224.

ESWL tedavisi gören hastalarda serum böbrek fonksiyon değerlerinde herhangi bir değişiklik olur mu?

Yıl 2022, Cilt: 15 Sayı: 2, 122 - 128, 31.08.2022
https://doi.org/10.52976/vansaglik.1035399

Öz

Amaç: Bu çalışmanın amacı, ESWL(Extracorporeal Shock Wave Lithotripsy) tedavisinin böbrek fonksiyon değerleri üzerine olan etkilerini incelemektir.
Gereç ve Yöntemler: Kasım 2019 ve Ekim 2020 tarihleri arasında, böbrek taşı nedeniyle ESWL tedavisi yapılan ve çalışma kriterlerine uyan 50 erişkin hasta ile gerçekleştirildi. Ürogenital anomalisi olan ve soliter böbrekli hastalar çalışmaya alınmamıştır. Hastaların ortalama yaşı 37,2(26-67) idi. Hastaların 31'i(%62) erkek, 19'u(%38) kadındı. Hastalara 3 seans ESWL yapıldı ve seanslar arası süre 7 gün olarak belirlendi. İlk ESWL seansından bir gün önce rutin serum değerleri (Rutin I) alındı, ilk ESWL seansından bir gün sonra (Rutin II) ve 3. ESWL seansından bir gün sonra (Rutin III) tekrarlandı.
Bulgular: Kan serumu elektrolit değerleri, serum kreatinin değeri, glomerül filtrasyon hızı(GFR) ve bikarbonat değerlerinin rutinler arasında istatistiksel olarak farklı olmadığı görüldü.
Sonuç: Çalışmamızda elde ettiğimiz bulgulara göre, ESWL'nin üst üriner sistem taşlarının tedavisinde kullanımının hastalarda böbrek tübüllerinde disfonksiyona yol açmadığı, böbrek fonksiyon değerlerinin takibine gerek olmadığını göstermektedir.

Proje Numarası

2021/05

Kaynakça

  • 1. Akinci M, Esen T, Tellaloğlu S. Urinary Stone disease in Turkey : an updated epidemiological study . Eur Urol. 1991;20: 200-203.
  • 2. Turna B, Nazlı O. Beden dışı şok dalga ile taş kırma. Türk Üroloji Dergisi 2005;31: 229-235.
  • 3. Weichert-Jacobsen K, Scheidt M, Külkens C, Loch T. Morphological correlates of urinary enzyme loss after extracorporeal lithotripsy. Urol Res. 1997;25(4): 257-62.
  • 4. Weichert-Jacobsen K, Stöckle M, Loch T, Brüske T. Urinary leakage of tubular enzymes after shock wave lithotripsy. Eur Urol. 1998;33: 104-110.
  • 5. Gunasekaran S, Donovan JM, Chvapil M, Drach GW. Effects of extracorporeal shock wave lithotripsy on the structure and function of rabbit kidney. J Urol. 1989;141: 1250-1254.
  • 6. Preminger GM. Review: in vivo effects of extracorporeal shock wave lithotripsy: animal studies. J Endourol. 1993;7: 375-378.
  • 7. Evan AP, Willis LR, Connors B. Shock wave lithotripsy-induced renal injury. Am J Kidney Dis. 1991;17: 445-450.
  • 8. Karlsen SJ, Smevik B, Hovig T. Acute morphological changes in canine kidneys after exposure to extracorporeal shock waves. A light and electron microscopic study. Urol Res. 1991;19: 105-115.
  • 9. Willis LR, Evan AP, Connors BA. Shockwave lithotripsy: dose-related effects on renal structure, hemodynamics, and tubular function. J Endourol. 2005;19: 90-101.
  • 10. Connors BA, Evan AP, Willis LR. The effect of discharge voltage on renal injury and impairment caused by lithotripsy in the pig. J Am Soc Nephrol. 2000;11: 310-318.
  • 11. Evan AP, Connors BA, Pennington DJ. Renal disease potentiates the injury caused by SWL. J Endourol. 1999;13: 619-628.
  • 12. Connors BA, Evan AP, Willis LR. Renal nerves mediate changes in contralateral renal blood flow after extracorporeal shockwave lithotripsy. Nephron Physiol. 2003;95: 67-75.
  • 13. Evan AP, Willis LR, Lingeman JE. Renal trauma and the risk of long-term complications in shock wave lithotripsy. Nephron. 1998;78: 1-8.
  • 14. Willis LR, Evan AP, Connors BA. Effects of extracorporeal shock wave lithotripsy to one kidney on bilateral glomerular filtration rate and PAH clearance in minipigs. J Urol. 1996;156: 1502-1506.
  • 15. El-Nahas AR, Awad BA, El-Assmy AM, et al. Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients? BJU Int. 2013;111(4):666–671.
  • 16. Assimos DG, Boyce WH, Furr EG. Selective elevation of urinary enzyme levels after extracorporeal shock wave lithotripsy. J Urol. 1989;142: 687-690.
  • 17. Recker F, Hofmann W, Bex A, Tscholl R. Quantitative determination of urinary marker proteins: a model to detect intrarenal bioeffects after extracorporeal lithotripsy. J Urol. 1992;148: 1000-1006.
  • 18. Rutz-Danielczak A, Pupek-Musialik D, RaszejaWanic B. Effects of extracorporeal shock wave lithotripsy on renal function in patients with kidney stone disease. Nephron. 1998;79: 162-166.
  • 19. Karlsen SJ1, Berg KJ. Acute changes in kidney function following extracorporeal shock wave lithotripsy for renal stones. Br J Urol. 1991;67(3): 241-5.
  • 20. Ilgın N, Iftehar SA, Vural G, Bozkirli I,Gokcora N. Evaluatian of renal function following treatment with ESWL : the use of whole –kidney, parenchymal and pelvic transit times . Nucl Med commun . 1998;19(2): 155 -9
  • 21. Goel MC, Baserge NS, Babu RV, Sinha S, Kapoor R. Pediatric kidney : functional outcome after ESWL. J Urol 1996;155(6): 2044-6
  • 22. Gupta M, Bolton DM, Irby P, Hubner W, Wolf JS, Hattner RS, Stoller ML. The effect of newer generation lithotripsy upon renal function assessed by nuclear scintigraphy . J Urol 1995:154(3); 947-50
  • 23. Pienkny AJ, Streem SB. Simultaneous versus staged bilateral extracorporeal shock wave lithotripsy: long-term effect on renal function. J Urol. 1999;162: 1591-1593.
  • 24. Perry KT, Smith ND, Weiser AC. The efficacy and safety of synchronous bilateral extracorporeal shock wave lithotripsy. J Urol. 2000;164: 644-647.
  • 25. Sheir KZ, Gad HM. Prospective study of the effects of shock wave lithotripsy on renal function . role of post-shock wave lithotripsy obstruction Urology 2003;61(6): 1102-6
  • 26. Saxby MF. Effects of PNL and ESWL on renal function and prostaglandin excreation. Scand J Urol Nrphrol 1997;31(2): 141-4
  • 27. Cass AS. Renal function after bilateral ESWL . J Endourol 1994;8(6): 395-9
  • 28. Greenstein A, Matzkin H, Kaver I, Baron J, Braf Z. Short term effect of a new portable extracorporal lithotripter on renal function . J Lithotr Stone Dis . 1990 ;2(4): 298-301
  • 29. El-Assmy A, El Nahas, Hekal IA, Bardan M, Youssef RF, Sheir KZ. Long- term effects of ESWL on renal function : our experience with 156 patients with solitary kidney . J Urol 2008; 179(6): 2229-32
  • 30. Villányi KK, Székely JG, Farkas LM. Short-term changes in renal function after extracorporeal shock wave lithotripsy in children. J Urol. 2001;166: 222-224.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırma Makaleleri
Yazarlar

İrfan Şafak Barlas 0000-0001-7894-9118

Selamettin Demir 0000-0003-1302-4127

Proje Numarası 2021/05
Yayımlanma Tarihi 31 Ağustos 2022
Gönderilme Tarihi 11 Aralık 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 15 Sayı: 2

Kaynak Göster

APA Barlas, İ. Ş., & Demir, S. (2022). Are there any changes in serum renal parameters in patients undergoing ESWL therapy?. Van Sağlık Bilimleri Dergisi, 15(2), 122-128. https://doi.org/10.52976/vansaglik.1035399

ISSN 

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