Comparison of the Effects of Medetomidine/Ketamine and Xylazine/Ketamine Anesthesia and Its Reversal by Atipamezole on Cardiovascular Functions in Cats

Öz

The aim of this study was to investigate the short-term cardiovascular effects of medetomidine/ketamine (MED-KET) and xylazine/ketamine (XYZ-KET) anesthesia regimes and its reversal (atipamezole) in cats through using echocardiography. Twenty sexually intact female cats (weighing between 2.2 and 3.6 kg, and between 0.5 and 5.5 years of age) referred for ovariohysterectomy procedure. Electrocardiogram, non-invasive blood pressure, respiratory rate, heart rate and pulse oximetry were monitored throughout the anesthesia. Both groups showed declines in left ventricular diameter (LVD%) and left ventricular ejection fraction (EF) after anesthesia induction (T0 vs. T1, all, p<0.05); nevertheless, the reduction and starting pattern of LVD% and left ventricular EF presented important intergroup distinction. In conclusion, echocardiographic values effected significantly after anesthesia with MED-KET and XYZ-KET; and atipamezole can be useful for return to baseline values quickly and safely in cats after abdominal surgery such as ovariohysterectomy.

Anahtar Kelimeler

• Antagonized
• Echocardiography
• Heart
• Atipamezole

Kedilerde Medetomidin/Ketamin ve Ksilazin/Ketamin Anestezisinin Kardiovasküler Fonksiyonlar Üzerindeki Etkilerinin ve Atipamezol ile Geri Dönüşümünün Karşılaştırılması

Öz

Bu çalışmanın amacı, medetomidin/ketamin (MED-KET) ve ksilazin/ketamin (KSZ-KET) anestezisindeki kedilerde kısa süreli kardiyovasküler etkilerini ve atipamezol ile bu etkilerinin geri dönüşümünü ekokardiyografi tekniği ile araştırmaktı. Erişkin 20 dişi kedi (ağırlığı 2.2-3.6 kg ve yaşı 0.5-5.5 arasında) ovariyohisterektomi için getirildi. Elektrokardiyogram, invaziv olmayan kan basıncı ölçümü, solunum sayısı, kalp atımı ve periferik oksijen düzeyi anestezi süresince izlendi. Her iki grup anestezi indüksiyonundan sonra sol ventrikül çapı (%LVD) ve sol ventrikül fırlatma fraksiyonu (EF) azalması (T0’a karşı T1, p<0.05) göstermiştir. Bununla birlikte azalma ve başlangıç değerlerine dönüş gruplar arasında istatistiki olarak farklıydı. Sonuç olarak, MED-KET ve KSZ-KET ile anestezi sonrası ekokardiyografik değerlerin anlamlı düzeyde etkilendiği ve atipamezolün, ovariohisterektomi gibi abdominal cerrahiler sonrasında kedilerde hızlı ve güvenli bir şekilde başlangıç değerlerine dönüş için faydalı olabileceği kanısına varıldı.

Anahtar Kelimeler

• Antagonist
• Ekokardiyografi
• Atipamezol
• Kalp

Kaynakça

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