Hidatik Kistli Sığırlarda Haptoglobin, Serum Amiloid A ve Diğer Bazı Akut Faz Proteinleri ile Biyokimyasal Parametrelerin Belirlenmesi

Öz

Çalışmada amaç hidatik kist ile enfekte sığırlarda bazı akut faz proteinleri ve biyokimyasal parametre düzeylerinin belirlenmesidir. Çalışmada çalışma grubunda hidatik kist ile enfekte 15, kontrol grubunda 15 olmak üzere toplam 30 adet Montofon sığır kullanıldı. Haptoglobin, serum amiloid A (SAA), seruloplazmin, interlökin (IL)-6, total protein, albümin, aspartat amino transferaz (AST), gama glutamil transferaz (GGT) ve alkalin fosfataz (ALP) aktivitesi, üre, kreatinin, demir (Fe) düzeyleri kolorimetrik olarak belirlendi. Hidatik kist ile enfekte hayvanlar ile kontrol grubu karşılaştırıldığında, haptoglobin, SAA, IL-6, AST, ALP, GGT aktivitesi, üre, kreatinin düzeyleri ve akut faz protein indeksi değerlerinin arttığı, albümin düzeylerinin ise azaldığı belirlendi. Ayrıca seruloplazmin ve total protein düzeylerinin arttığı, globulin, albümin/globulin ve Fe düzeylerinin ise azaldığı ancak istatistiksel olarak anlamlı olmadığı belirlendi. Sonuç olarak hidatik kist ile enfekte hayvanlarda biyokimyasal parametrelerde önemli değişiklikler, haptoglobin ve SAA sentezinde artış olduğu belirlenmiş olup bu parametrelerin hastalığın patogenezine ve tanısına katkı sağlayabileceği düşünülmektedir.

Anahtar Kelimeler

• Haptoglobin
• Hidatik kistler
• Sığır
• Serum amiloid A

Determination of Haptoglobin, Serum Amyloid A, Some Other Acute Phase Proteins, and Biochemical Parameters in Cattle with Hydatid Cysts

Öz

The aim of this study is to determine some acute phase proteins and biochemical parameter levels in cattle infected with the hydatid cysts. In the study, a total of 30, Brown Swiss cattle including 15 infected with the hydatid cysts in the study group and 15 in the control group were used. Haptoglobin, serum amyloid A (SAA), ceruloplasmin, interleukin (IL)-6, total protein, albumin, aspartate amino transferase (AST), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) activity, urea, creatinine, iron (Fe) levels were determined colorimetrically. When the animals infected with hydatid cysts and control group were compared, it was determined that haptoglobin, SAA, IL-6, AST, ALP, GGT activity, urea, creatinine levels and acute phase protein index values increased, while albumin levels decreased. In addition, it was determined that the ceruloplasmin and total protein levels increased, globulin, albumin/globulin and Fe levels decreased, but they were statistically insignificant. In conclusion, it was determined that there were significant changes in the biochemical parameters and increased haptoglobin and SAA synthesis in the animals infected with the hydatid cysts, and it is thought that these parameters may contribute to the pathogenesis and diagnosis of the disease.

Anahtar Kelimeler

• Cattle
• Haptoglobin
• Hydatid cysts
• Serum amyloid A

Kaynakça

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