Histopathological Evaluation of the Anti-Obesity Effects of the Plant Kenger (Gundelia tournefortii L.) in an Experimental Model of Obesity Induced in Rats

Yıl 2024, , 213 - 217, 28.11.2024

Ömer Faruk Keleş , Bedia Bati

https://doi.org/10.36483/vanvetj.1558632

Öz

In this study, the anti-obesity effects of Gundelia tournefortii extract were histopathologically investigated in experimental obesity induced by a high-calorie diet in rats. For this purpose, Wistar-Albino male rats were divided into four groups, each consisting of 10 rats: Control (C), High-Calorie Diet (HC), High-Calorie Diet + Gundelia tournefortii 200 mg/kg (HCG1), and High-Calorie Diet + Gundelia tournefortii 400 mg/kg (HCG2). The study was conducted over a period of three months. Histopathological analyses of liver tissue samples revealed that the HC group exhibited fatty degeneration, with coagulation necrosis observed in hepatocytes. In the HCG1 group, the liver showed macro-microvesicular fat vacuoles in hepatocytes of the pericentral regions, although this accumulation was significantly milder compared to the HC group. Conversely, the HCG2 group displayed a histological appearance close to that of the control group, with only rare microvesicular fat vacuoles in hepatocytes. As a result, it is evaluated that the Gundelia tournefortii extract given with a high-calorie diet in rats has a hepatoprotective effect.

Anahtar Kelimeler

Gundelia tournefortii, Histopathology, Obesity

Deneysel Obezite Modeli Oluşturulan Ratlarda Kenger (Gundelia tournefortii L.) Bitkisinin Antiobezite Etkisinin Histopatolojik Olarak Değerlendirilmesi

Öz

Bu çalışmada, yüksek kalorili diyet ile deneysel obezite oluşturulan ratlarda, kenger (Gundelia tournefortii) bitki ektresinin antiobezite etkisinin histopatolojik olarak araştırılması amaçlanmıştır. Bu amaçla Wistar-Albino ırkı erkek ratlar, her grupta 10 rat olacak şekilde toplam 4 gruba Kontrol (K), Yüksek Kalorili Diyet (YK), Yüksek Kalorili Diyet + Gundelia tournefortii 200mg/kg (YKG1), Yüksek Kalorili Diyet + Gundelia tournefortii 400 mg/kg (YKG2) ayrıldı ve çalışma 3 ay süre ile yürütüldü. Elde edilen sonuçlara göre, karaciğerlerden alınan doku örneklerinden yapılan histopatolojik analizler sonucunda; YK grubunda yağlanma ile hepatositlerin bazısında ise koagulasyon nekrozu izlenmiştir. Ayrıca YKG1 grubundaki ratların karaciğerlerinde YK grubunda olduğu gibi lopçukların periasiner bölgelerindeki hepatositlerde makro-mikroveziküler yağ vakuollerinin bulunduğu, ancak bu birikimlerin YK grubuna göre çok daha hafif olduğu gözlenmiştir. Diğer yandan, YKG2 grubunda histolojik görünümün kontrol grubuna yakın olmakla birlikte hepatositlerde çok seyrek olarak mikroveziküler yağ vakuollerinin bulunduğu tespit edilmiştir. Sonuç olarak; ratlarda yüksek kalorili diyet ile birlikte verilen kenger bitki ekstresinin, hepatoprotektif etkisinin olduğu değerlendirilmektedir.

Anahtar Kelimeler

Gundelia tournefortii, Histopatoloji, Obesite.

Kaynakça

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