Investigation of the Effect of Liver Supportive Feed Additives on Metabolic Profile Tests and Colostrum Dry Matter of Dairy Cows in Dry Period

Yıl 2025, Cilt: 36 Sayı: 2, 71 - 79, 27.07.2025

Gencay Ekinci , Veli Özbek

https://doi.org/10.36483/vanvetj.1630406

https://izlik.org/JA65ST97HT

Öz

This study aimed to investigate the effects of a liver-supportive feed additive (LSFA) on metabolic profile parameters and colostrum dry matter (DM) content in dairy cows during the dry period. A total of 34 clinically healthy cows (18 Holstein and 16 Simmental), aged between 3 and 5 years, were randomly assigned to two groups at the onset of the dry period: the study group (SG; n=17) and the control group (CG; n=17). While the CG received only the standard dry period ration, the SG was additionally supplemented with 100 g/cow/day of LSFA for 15 consecutive days. Blood samples were collected on day 0 and day 35 of the dry period to assess macro-mineral levels and selected metabolic profile parameters. Colostrum samples were obtained within two hours postpartum, and DM content was measured using an optical Brix refractometer. On day 35, the mean blood urea nitrogen (BUN) level in the SG was significantly lower compared to day 0 (p=0.007), whereas the mean aspartate aminotransferase (AST) activity was significantly higher (p<0.001). Additionally, the average colostrum DM content in the SG (Brix=26.67±1.14%) was significantly greater than that in the CG (Brix=25.80±0.83%) (p=0.029). These results indicate that LSFA supplementation may influence liver-related nitrogen metabolism, as evidenced by decreased BUN levels and increased AST activity-an enzyme commonly associated with hepatic cellular damage. Although these findings suggest a potential impact of LSFA on liver function, definitive conclusions cannot be drawn without more comprehensive evaluations involving an extended biochemical panel. Future studies incorporating liver function enzymes, protein fractions, and antioxidant parameters are warranted to better elucidate the physiological effects of such feed additives.

Anahtar Kelimeler

Cattle , Colostrum , Metabolic profile tests , Minerals , Peripartum period

Etik Beyan

This study was conducted with the permission of Erciyes University Animal Experiments Local Ethics Committee on 04.12.2024 with the number 24/233.

Destekleyen Kurum

The author(s) received no financial support for the research.

Teşekkür

We would like to thank the farm and laboratory staff for their help and support in carrying out this research project.This study has not been presented as an oral/poster presentation in any congress and has not been published as an abstract in the congress book.

Kuru Dönemdeki Sütçü Sığırlarda Karaciğer Koruyucu Yem Katkı Maddelerinin Kolostrum Bileşimi ve Metabolik Profil Üzerine Etkileri

https://izlik.org/JA65ST97HT

Öz

Bu çalışmanın amacı, kuru dönem süt sığırlarında karaciğer destekleyici bir yem katkı maddesinin (KDYK) metabolik profil parametreleri ve kolostrum kuru madde (KM) düzeyi üzerine etkilerini araştırmaktır. Çalışmaya 3-5 yaş aralığında, klinik olarak sağlıklı toplam 34 inek (18 Holstein, 16 Simmental) dâhil edilmiştir. Kuru dönemin başında rastgele olarak iki gruba ayrılan hayvanlardan 17’si çalışma grubunu (ÇG), 17’si ise kontrol grubunu (KG) oluşturmuştur. Kontrol grubundaki ineklere yalnızca kuru dönem rasyonu uygulanırken, çalışma grubundaki ineklere bu rasyona ek olarak 15 gün boyunca günlük 100 g/inek KDYK verilmiştir. Kuru dönemin 0. ve 35. günlerinde alınan kan örneklerinden makro mineraller ve bazı metabolik profil parametreleri analiz edilmiştir. Kolostrum örnekleri doğumdan sonraki ilk iki saat içinde toplanmış ve kuru madde düzeyi optik Brix refraktometresi ile ölçülmüştür. Çalışma grubundaki ineklerin 35. gün ortalama serum BUN düzeyi, 0. güne göre istatistiksel olarak anlamlı şekilde düşük bulunmuştur (p=0.007). Buna karşılık, aynı grubun ortalama AST düzeyi 35. günde, 0. güne kıyasla anlamlı şekilde yüksek tespit edilmiştir (p<0.001). Ayrıca, çalışma grubundaki ineklerden elde edilen kolostrumun ortalama KM oranı (Brix=%26.67±1.14), kontrol grubuna göre (Brix=%25.80±0.83) anlamlı düzeyde daha yüksek bulunmuştur (p=0.029). Elde edilen bulgular, KDYK kullanımının karaciğerde azot metabolizmasını etkileyebileceğini ve karaciğer hücre hasarının biyokimyasal göstergelerinden biri olan AST enzimi aktivitesinde artışa yol açabileceğini göstermektedir. Bununla birlikte, bu etkinin karaciğer fonksiyonları üzerindeki kesin yansımaları, daha kapsamlı ve doğrudan karaciğer değerlendirmeleri yapılmadan net olarak belirlenemez. Bu nedenle, karaciğer fonksiyon enzimleri, protein fraksiyonları ve antioksidan parametreleri gibi daha geniş bir biyokimyasal paneli içeren kontrollü çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Kolostrum , Metabolik profil testleri , Mineraller , Peripartum dönem , Sığır

Etik Beyan

Bu çalışma Erciyes Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu'nun 04.12.2024 tarih ve 24/233 sayılı izni ile gerçekleştirilmiştir.

Teşekkür

Bu araştırma projesinin yürütülmesinde yardım ve desteklerinden dolayı çiftlik ve laboratuvar personeline teşekkür etmek isteriz. Bu çalışma herhangi bir kongrede sözlü/poster sunumu olarak sunulmamış ve kongre kitabında özet olarak yayınlanmamıştır.

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