Stem Cell Therapy As A Regenerative Approach In Veterinary Medicine

Yıl 2017, Cilt: 28 Sayı: 2, 117 - 121, 20.08.2017

Duygu Dalğın , Yücel Meral

Öz

Stem
cells are promising alternatives in chronic diseases of animals as well as
humans. Stem cells has two differentiating characteristics; First, they are
unspecilized cells with the self renewing capacity by cell division, even after
long periods of inactivity. Second, they differentiate to tissue or organ
spesific cells with speciliazed functions, under physiologic or culture
conditions. Stem cells provide the potential for many outstanding subjects such
as gene targeting, cloning, chimera production and transgenic animal formation.
The ability of stem cells to differentiate to 200 different cell types in the
organism places them to a major step among theraupetic agents. Literature
establishes that stem cell therapy is a feasible regenerative alternative.
Several companies in Turkey supplies safe and licensed products. Among the stem
cells, those with the best chance of therapeutic success are the mesentheric
stem cells (isolated from bone marrow or adipose tissue), due to their ability
to promote tissue repair, activation of paracrine factors, immunomodulation,
and perception of the cell homing signaling. These cells are predominantly
preferred in pets for bone diseases, tendons and cartilage, muscles, and other
tissues. Stem cell therapy must be more prevalantly used in companion animal
medicine, certainly by the skilled practitioners and standartized and licenced
material. This review summarizes the current literature and endications of stem
cell therapy in veterinary medicine.

Anahtar Kelimeler

Veterinary medicine, Regenerative Therapy, Stem cell

Veteriner Hekimlikte Rejeneratif Tedavi Yaklaşımı Olarak Kök Hücre Tedavisi

Öz

Kök
hücreler beşeri hekimlikte olduğu kadar veteriner hekimlikte de kronik
hastalıkların tedavisi açısından umut verici bir alternatifir. Kök hücrelerin
iki önemli özelliği bulunur; ilki uzun inaktivite dönemlerinden sonra bile
hücre bölünmesi yoluyla öz yenileme kapasitesine sahip özelleşmemiş hücrelerdir
ve ikincisi fizyolojik veya kültür şartlarında farklı organ ve doku
sistemlerine ait hücre dizilerine dönüşebilirler. Kök hücreler, gen hedefleme,
klonlama, kimera üretimi ve transgenik hayvan üretimi gibi pek çok ilgi çekici
konu açısından potansiyel oluştururlar. Kök hücrelerin organizmada 200’den
fazla hücreye dönüşebilme kabiliyeti, terapötik ajanlar arasında önemli bir yer
almasını sağlar. Literatür kök hücre tedavinsin uygulanabilir bir rejeneratif
alternatif olduğunu ortaya koymaktadır. 
Türkiye’de birkaç şirket güvenli ve ruhsatlı ürünler arz etmektedir. Kök
hücre tipleri arasında doku tamiri kapasitesi, parakrin faktör aktivasyonu,
immunmodülasyon gibi faktörler baz alınarak terapötik başarı şansı en yüksek
olanı mezenterik kök hücreler (kemik iliği veya yağ doku kökenli) olarak
belirlenmiştir. Bu hücreler petlerin kemik, tendon ve kıkırdak hasarları ve
diğer doku hastalıklarında en sık tercih edilen tiptir. Kök hücre tedavisi,
elbette eğitimli personel ve ruhsatlı ürünler kullanılarak küçük hayvan
hekimliğinde daha yaygın olarak yer almalıdır. Bu derlemede güncel literatür ve
veteriner hekimlikte kök hücre tedavi endikasyonları özetlenmiştir.

Anahtar Kelimeler

Veteriner hekimlik, Rejeneratij Tedavi, Kök hücre

Kaynakça

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