DRUG USE AND TERATOGENITY IN PREGNANCY

Yıl 2022, , 90 - 98, 31.08.2022

Sara Buşra Emiroğlu Fatih Sakin

https://doi.org/10.38137/vftd.1082673

Öz

The pharmacokinetic properties of many drugs change due to the physiological changes shaped on the pregnant animals during pregnancy, so it is necessary to regulate the dosage regimen in pregnant. In addition, the existence of teratogenic effects of some drugs on the fetus or embryo limits the use of drugs in pregnant. Risk classification systems constituted to prevent these risks guide physicians. However, since these classification systems are not suitable for all species, their use is limited in the field of veterinary medicine and can provide an estimate for veterinarians about the harmful effects it may cause in other species. In this review, it is aimed to specify drug use, teratogenic drugs and their effects in pregnant, and also to guide veterinarians about drug use in pregnant patients.

Anahtar Kelimeler

Drug, pregnancy, teratogenicity

Teşekkür

Bu derleme 6th International Congress on Veterinary and Animal Sciences (ICVAS) 02-04 Eylül 2021 tarihinde özet bildiri olarak sunulmuştur.

GEBELİKTE İLAÇ KULLANIMI VE TERATOJENİTE

Öz

Gebelik sırasında annede şekillenen fizyolojik değişiklikler nedeniyle birçok ilacın farmakokinetik özelliği değişmekte, bu nedenle gebelerde dozaj rejimini düzenlemek gerekmektedir. Bunun yanında bazı ilaçların fetüs ya da embriyo üzerinde teratojenik etkilerinin varlığı gebelerde ilaç kullanımını sınırlandırmaktadır. Bu risklerin önüne geçmek amacıyla oluşturulan risk sınıflandırma sistemleri hekimlere rehberlik etmektedir. Ancak bu sınıflandırma sistemleri her tür açısından uygun olmadığı için özellikle veteriner hekimlik alanında kullanımı sınırlı olmakta ve diğer türlerde oluşturabileceği zararlı etkileri hakkında veteriner hekimlere bir tahmin sunabilmektedir. Bu derlemede gebelerde ilaç kullanımı, teratojenik ilaçlar ve etki şekillerini belirtmek, ayrıca veteriner hekimlerin gebe hastalarına ilaç kullanımı hakkında rehber olmak amaçlanmıştır.

Anahtar Kelimeler

Gebelik, ilaç, teratojenite

Kaynakça

• Addis, A., Sharabi, S. & Bonati, M. (2000). Risk classification systems for drug use during pregnancy. Drug Safety, 23 (3), 245-253.
• Autio, K., Rassnick, K. M. & Bedford‐Guaus, S. J. (2007). Chemotherapy during pregnancy: a review of theliterature. Veterinary and Comparative Oncology, 5 (2), 61-75.
• Beckman, D. A. & Brent, R. L. (1984).Mechanisms of teratogenesis. Annual Review of Pharmacology and Toxicology, 24 (1), 483-500.
• Branch, S. (2004). Teratogenesis. A Textbook of Modern Toxicology, 251-259.
• Boothby, L. A. & Doering, P. L. (2001). FDA labeling system for drugs in pregnancy. Annals of Pharmacotherapy, 35 (11), 1485-1489.
• Clegg, D. J. (1971). Teratology. Annual Review of Pharmacology,11 (1), 409-424.
• Coppock, R. W. & Dziwenka, M. M. (2017). Teratogenesis in livestock. In Reproductive and Developmental Toxicology, 1391-1408.
• Doll, D. C., Ringenberg, Q. S. & Yarbro, J. W. (1989).Antineoplastic agents and pregnancy. Seminars in Oncology, 16, 337-346.
• Donald, C. (2008). Plumb’s Veterinary Drug Handbook. 6th Ed. Pharma Vet Inc, Stockholm, Minnesota. Freytag TL, Liu SM, Rogers QR & Morris JG. (2003). Teratogenic effects of chronic ingestion of high levels of vitamin A in cats. Journal of animal physiology and animal nutrition, 87(1‐2), 42-51.
• Fthenakis, G. C., Mavrogianni, V. S., Gallidis, E. & Papadopoulos, E. (2015). Interactions between parasitic infections and reproductive efficiency in sheep. Veterinary Parasitology, 208 (1-2), 56-66.
• Harris, W. H. (1977).Hazards of administering drugs to pregnant animals: a review. The Canadian Veterinary Journal,18 (11), 309.
• Kaplan, B. S., Restaino, I., Raval, D. S., Gottlieb, R. P. & Bernstein, J. (1994). Renal failure associated with in utero exposure to non-steroidal anti-inflammatory agents. Pediatr Nephrol, 8, 700–704.
• Mastroiacovo, P., Mazzone, T., Botto, L. D., Serafini, M. A., Finardi, A., Caramelli, L. & Fusco, D. (1996). Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole. Am J Obstet Gynecol, 175, 1645-1650. Mathews, K. A. (2005). Analgesia for the pregnant, lactating and neonatal to pediatric cat and dog. Journal of Veterinary Emergency and Critical Care, 15 (4), 273-284.
• Menegola, E., Broccia, M. L., DiRenzo, F., Massa, V. & Giavini, E. (2005). Study on the common teratogenic pathway elicited by the fungicides triazole- derivatives. Toxicol in Vitro, 19 (6), 737-748.
• Miral, M. & Kızılkaya, B. N. (2017). Gebelikte ilaç kullanımı ve danışmanlık. Sağlık Bilimleri ve Meslekleri Dergisi, 4 (2), 142-148. Papich, M. G. (1989). Effects of drugs on pregnancy. In: Current Veterinary Medicine X: RW Kirk, ed.,Philadelphia, WB SaundersCo, 1291-1299.
• Pentheroudakis, G. & Pavlidis, N. (2006). Cancer and pregnancy: poenamagna, not anymore. European Journal of Cancer, 42, 126-140.
• Pichler, L. (2007). Teratogenicity in dogs and cats a review for practitioners and toxicologists. Wiener Tierarztliche Monatsschrift, 94, 214-222.
• Rebuelto, M. & Loza, M. E. (2010). Antibiotic treatment of dogs and cats during pregnancy. VeterinaryMedicine International, 1-8.
• Salman, M., Abbas, R. Z., Mehmood, K., Hussain, R., Shah, S., Faheem, M., Asghar, A., Morales, B., Aneva, I. & Martínez, J. L. (2022). Assessment of Avermectins-Induced Toxicity in Animals. Pharmaceuticals, 15 (3), 332.
• Shehata, H. A. & Nelson-Piercy, C. (2001). Drugs to avoid. Best Practice and Research: Clinical Obstetrics and Gynaecology, 15 (6), 971–986.
• Teruel, M., Catalano, R. & Salomón, L. (2011). Albendazole sulphoxide administered prior to mating and its relation with fertilization and mouse embryo development. Int J Morphol, 29 (3), 816-820.
• Ujhazy, E., Mojmir, M., Navarova, J., Brucknerova, I. & Dubovicky, M. (2012).Teratology past, present and future, Interdisciplinary Toxicology, 5 (4), 163-168.
• Vural, M. R. (1991). Gebelik süresince ilaç etkileşmeleri ve ilaçla tedavi. Ank Univ Vet Fak Derg, 38 (03), 257-265.
• Wiebe, V. J. & Howard, J. P. (2009). Pharmacologic advances in canine and feline reproduction. Topics in Companion Animal Medicine, 24 (2), 71-99.
• Wilson, J. G. (1973). Environment and Birth Defects. New York: Academic. 305.
• Yıldız, K. (2021). Veteriner Parazitolojide Güncel Aşılar. Turkiye Parazitol Derg, 45 (4), 304-10.