1. DergiPark
  2. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni
  3. Arşiv
  4. Cilt 10, Sayı 3
Yıl 2019, Cilt 10 , Sayı 3, Sayfalar 125 - 134 2019-12-30

Luteal Progesterone Biosynthesis in Cattle and its Molecular Control Mechanism
İNEKLERDE LUTEAL PROGESTERON BİYOSENTEZİ ve MOLEKÜLER KONTROL MEKANİZMASI

Ruhi KABAKÇI [1] , Ayşe Arzu YİĞİT [2]

Öz

The corpus luteum (CL) takes an important place in cows which are able to reproductive activity throughout the year with a regular estrus cycle lasting twenty-one days. Corpus luteum occurs at the site of follicle wreck immediately after ovulation and maintains its presence during diestrus phase which is the longest period of the estrous cycle. The most critical and essential function of the CL is the production of progesterone (P4). This function is performed by the small and large luteal cells which are differentiated from theca and granulosa cells in the follicle wall by stimulation of luteinizing hormone (LH). Progesterone synthesized from cholesterol via steroidogenic enzymes has important roles such as regulation of estrus cycle and maintenance of pregnancy. In this review, it is presented the molecular control mechanism of progesterone biosynthesis in bovine luteal cells and the steroidogenic enzymes such as cytochrome p450s (CYP11A1), steroidogenic acute regulatory (StAR) protein, 3-Hydroxysteroid dehydrogenase (3β-HSD). It is thought that reproductive physiology will be better understood by knowing the details of molecular mechanisms of cows which have a significant economic value and should have a healthy reproductive system.

Yirmi bir gün süren düzenli östrus siklusu ile yıl boyu üreme aktivitesi gösterebilen ineklerde korpus luteum (KL)’un önemli bir yeri bulunmaktadır. Ovulasyonla yumurta hücresinin atılmasından hemen sonra, folikül enkazının bulunduğu yerde oluşmaya başlayan KL, östrus siklusunun en uzun dönemi olan diöstrus fazında varlığını sürdürmektedir. Korpus luteumun en önemli ve temel görevi progesteron (P4) sentezlemektedir. Bu görevi folikül duvarındaki Granuloza ve Teka hücrelerinin luteinleştirici hormon (LH) uyarımı ile farklılaşmasıyla meydana gelen büyük ve küçük luteal hücreler gerçekleştirmektedir. Steroidojenik enzimler aracılığıyla kolesterolden sentezlenen progesteronun, östrus siklusunun düzenlenmesi ve gebeliğin devamlığını sağlama gibi önemli görevleri bulunmaktadır. Hazırlanmış olan bu derlemede, inek luteal hücrelerinde meydana gelen P4 biyosentezi ve sentezin moleküler kontrol mekanizması ile bu aşamalarda rol oynayan sitokrom p450s (CYP11A1), steroidojenik akut düzenleyici (StAR) protein, 3-Hidroksisteroit dehidrojenaz (3β-HSD) gibi steroidojenik enzimler hakkında bilgi verildi. Bu moleküler mekanizmaların ayrıntılarının bilinmesi ile, önemli ekonomik değeri bulunan ve sağlıklı bir üreme sistemine sahip olması gereken ineklerde, üreme fizyolojisinin daha iyi anlaşılacağı düşünülmektedir.

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Ayrıntılar

Birincil Dil tr
Konular Veteriner Hekimlik
Bölüm Derleme
Yazarlar

Orcid: 0000-0001-9131-0933
Yazar: Ruhi KABAKÇI (Sorumlu Yazar)
Kurum: KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ
Ülke: Turkey

Orcid: 0000-0001-5837-6877
Yazar: Ayşe Arzu YİĞİT
Kurum: KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ
Ülke: Turkey
Tarihler

Yayımlanma Tarihi : 30 Aralık 2019

Kaynak Göster

APA Kabakçı, R , Yiğit, A . (2019). İNEKLERDE LUTEAL PROGESTERON BİYOSENTEZİ ve MOLEKÜLER KONTROL MEKANİZMASI . Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni , 10 (3) , 125-134 . Retrieved from https://dergipark.org.tr/tr/pub/vetfarmatoksbulten/issue/51046/650155
Makalenin Yazarları
Ruhi KABAKÇI [1]
Ayşe Arzu YİĞİT [2]
Makale Gönder
Kabul Edilmiş Makaleler
Arşiv
Editör Kurulu
İletişim


  


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