Yıl 2019, Cilt 10 , Sayı 3, Sayfalar 152 - 158 2019-12-30

ANTİNEMATODAL İLAÇLARIN SİTOKİNLER ÜZERİNE ETKİLERİ
THE EFFECTS OF ANTINEMATODAL DRUGS ON CYTOKINES

Ayşe ÇIRAK [1] , Ebru YILDIRIM [2]


Sitokin üretimini etkileyen faktörlerden biri de ilaçlardır. Veteriner pratikte sahada en çok kullanılan ilaç gruplarından biri nematodlara karşı kullanılan antelmintiklerdir. Benzimidazol grubu bazı ilaçların (albendazol, mebendazol, fenbendazol), organik fosforlu insektisidlerin, avermektin gibi ilaçların da sitokinler üzerine etkili olduğu gösterilmiştir. Bu derleme nematodlara karşı kullanılan ilaçların sitokinler üzerindeki etkileri özetlenecektir. Bu etkilerin daha iyi araştırılması nematod kaynaklı hastalıkların tedavi ve korunmasında ilaç kullanım yaklaşımlarına önemli katkılar sağlayacaktır.

One of the factors affecting cytokine production is drugs. In veterinary practice, one of the most commonly used drugs in the field are anthelmintics against nematodes. Some benzimidazole drugs (albendazole, mebendazole, fenbendazole), organic phosphorus insecticides, avermektin have been shown to be effective on cytokines. This review summarizes the effects of drugs against nematodes on cytokines. A better investigation of these effects will contribute to drug use approaches in the treatment and prevention of nematode-borne diseases.

  • Abate E, Elias D, Getachew A, Alemu S, Diro E, Britton S, Aseffa A, Stendahl O, Schön T ( 2015) Effects of albendazol on the clinical outcome and immunological responses in helminth co-infected tuberculosis patients: a double blind randomised clinical trial. International Journal of Parasitology, 45:133-140 Betancourt A, Lyons ET, Horohov DW (2015) Characterisation of the inflammatory cytokine response to anthelmintic treatment in ponies. Equine Veterinary Journal, 47:240-244. Binukumar BK, Bal A, Gill KD (2011). Chronic dichlorvos exposure: Microglial proinflammatory cytokines and damage to nigrostriatal dopaminergic system. Neuromol Med, 13: 251-265. Boura P, Raptopoulov GM, Acrıvıadıs F. Goulıs G (1984) Reevaluation of the effect of levamisole in chronic brucellosis : in vitro and in vivo effect on monocyte phagocytosis. J Immunopharmacol, 6:135-146.
  • Cai Y, Zhou J, Webb D (2009) Treatment of mice with fenbendazole attenuetes allergic airway inflammation and Th2 cytokine production in a model of asthma. Immunology and Cell Biology, 87: 623-629. Chen LY, Lin LY, Chiang BL ( 2008) Levamisole enhances immune response by affecting the activation and maturation of human monocyte-derived dendritic cells. Clinical and Experimental Immunology, 151:174-181.
  • Çelik C (1998) Antelmintik İlaçların Biyokimyasal Etki Yolları. Ondokuz Mayıs Üniv. Tıp Fak. Dergisi, 5:243-251. de-la-Rosa-Arana JL, Campos-Rodríguez R, Rivera-Aguilar V, Escobar-Gutiérrez A, Miliar-García Á, Herrera-González NE, Jarillo-Luna RA (2012) Comparative effects of levamisole, Staphylococcus, and Freund's adjuvant on rat immunization with excretory and secretory antigens of Trichinella spiralis muscle larvae. Parasitology research, 111:1599-1605. Diker S (1998).Sitokinler. Alındı: İmmunoloji.,Ed.: KS Diker, 2. Baskı, Medisan Yayınevi, Ankara, s: 85-93. Foster J. R. (2001). The functions of cytokines and their uses in toxicology. International journal of experimental pathology, 82(3), 171–192. doi:10.1046/j.1365-2613.2001.iep0082-0171-x Güner İ, Özmen D, Bayındır O (1997). Cytokines. T Klin J Med Sci 17: 65-74. Kaya S (2013). Antelmintikler. Alındı: Veteriner Farmakoloji 2, Ed: S. Kaya, Medisan Yayınevi, Ankara, s: 469-525. Kaya S (2014). Pestisidler. Alındı: Veteriner Toksikoloji, Ed.:S. Kaya, Medisan Yayınevi, Ankara, s: 301-392. Kayaalp OS (2000a). Antelmintik İlaçlar. Alındı: Tıbbi Farmakoloji 1, Ed.: SO Kayaalp, 9.baskı, Hacettepe-Taş, Ankara, s: 336-342. Kayaalp OS (2000b) İmmun Sistem Bozuklukları ve İmmunomodülatör İlaçlar. Alındı: Tıbbi Farmakoloji 1. 9.baskı, , Hacettepe-Taş, Ankara, s: 408-418. Li Q (2007) New mechanism of organophosphorus pesticides-induced immunotoxicity. J Nippon Med Sch, 74: 92-105. Liu C, Li M, Cao Y, Qu JP, Zhang ZW, Xu SW, Li S. (2014) Effects of avermectin on immune function and oxidative stress in the pigeon pleen. Chemico-Biological Interactions, 210: 43-50. Mizuno K, Toyoda Y, Fukami T, Nakajima M, Yokoi T (2011) Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway. Archives of Toxicology, 85: 199-207. Mohamed, E.H., Baiomy, A.A., Ibrahim, Z.S., & Soliman, M.M. (2016). Modulatory effects of levamisole and garlic oil on the immune response of Wistar rats: Biochemical, immunohistochemical, molecular and immunological study. Molecular Medicine Reports, 14, 2755-2763. https://doi.org/10.3892/mmr.2016.5551 Nageshwari B, Merugu R. (2017). Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines. Indian J Cancer, 54:566-71 Nielsen MK, Rubinson EF, Chambers TM, Horohov DW, Wagner B, Betancourt A, Reedy SE, Jacobsen S (2015) Interaction between anthelmintic treatment and vaccine responses in ponies naturally infected with cyathostomins. Veterinary Immunology and Immunopathology, 164: 110-117. Raisov TK, Sadykov KB, Temirbekov DA, Ozeretskovskaia NN (1987) Effect of mebendazole on the immune reaction of guinea pigs with experimentally infected with Trichinella. Meditsinskaya-Parasitologiya i Parazitarnye Bolezni, 6: 14-17. Rocha SW, de França ME, Rodrigues GB, Barbosa KP, Nunes AK, Pastor AF, Oliveira AG, Oliveira WH, Luna RL, Peixoto CA (2014) Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators of Inflammation, Erişim:[ http://www.ncbi.nlm.nih.gov/pubmed/25374445], Erişim tarihi: 21.12.2015 Singh AK, Singh SK, Singh A, Gupta KK, Khatoon J, Prasad A, Rai RP, Gupta RK, Tripathi M, Husain N, Prasad KN (2015) Immune response to taenia solium cysticerci after anti-parasitic therapy. International Journal for Parasitology, 45: 749-759. Szeto C, Gillespie KM, Mathieson PW (2000) Levamisole induces interleuken-18 and shifts type 1/type 2 cytokine balace. Immunology, 100:217-224. Yan S, Ci X, Chen N, Chen C, Li X (2011) Anti-inflammatory effects of ivermectine in Mouse model of allergic asthma. Inflammation Research, 60: 589-596. Webb EL, Mawa PA, Ndibazza J, Kizito D, Namatovu A, Lugemwa JK, Nanteza B, Nampijja M, Muhangi L, Woodburn PW, Akurut H, Mpairwe H, Akello M, Lyadda N, Bukusuba J, Kihembo M, Kizza M, Kizindo R, Nabulime J, Ameke C, Namujju PB, Tweyongyere R, Muwanga M, Whitworth JAG, Elliot AM (2011) Effect of single-dose anthelmintic treatment during pregnancy on an infant’ s response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-conrolled trial. Lancet, 377: 52-62. Zabrodskii PF, Gromov MS, Yafarova I Kh (2014). Dysfunction of Th1 and Th2 lymphocytes and change in blood cytokine concentration at various stages of chronic intoxication with organophosphorus compounds. Bulletin of Experimental Biology and Medicine, 156:789-792. Zhang JM, An J (2007) Cytokines, Inflammation and Pain. Int Anesthesiol Clin, 45:27-37.Zidek Z, Anzenbacher P, Kmonickova E (2009) Current satatus and challenges of cytokine pharmacology. British Journal of Pharmacology, 157: 342-361. Zidek Z, Anzenbacher P, Kmonickova E (2009) Current satatus and challenges of cytokine pharmacology. British Journal of Pharmacology, 157: 342-361.
Birincil Dil tr
Konular Veteriner Hekimlik
Bölüm Derleme
Yazarlar

Orcid: 0000-0002-7211-6008
Yazar: Ayşe ÇIRAK
Kurum: Kalecik Tarım ve Orman İlçe Müdürlüğü
Ülke: Turkey


Orcid: 0000-0002-6289-0729
Yazar: Ebru YILDIRIM (Sorumlu Yazar)
Kurum: KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 30 Aralık 2019

APA Çırak, A , Yıldırım, E . (2019). ANTİNEMATODAL İLAÇLARIN SİTOKİNLER ÜZERİNE ETKİLERİ . Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni , 10 (3) , 152-158 . Retrieved from https://dergipark.org.tr/tr/pub/vetfarmatoksbulten/issue/51046/657578