Yıl 2019, Cilt 10 , Sayı 3, Sayfalar 135 - 151 2019-12-30

ANTIOXIDANT VITAMINS AND ITS EFFECTS ON HEAVY METAL TOXICITY
ANTİOKSİDAN VİTAMİNLER VE AĞIR METAL TOKSİSİTESİ ÜZERİNE ETKİLERİ

Canan İRİŞ [1] , Miyase ÇINAR [2]


Many defense systems known antioxidants have been developed in the body to prevent the effects of free radicals. One of the body's defense systems is endogenous antioxidants; vitamins A (β-carotene), C and E . Especially heavy metal pollution such as mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) poses a threat to the life of all living things. The common mechanism that determines the toxicity of heavy metals is the formation of oxidative stress. Antioxidant defense may be insufficient when intense oxidative stress occurs. In this review, the effects of antioxidant vitamins in toxicity caused by heavy metals and especially in the prevention against free radical formation were evaluated.
Vücutta antioksidanlar adıyla bilinen serbest radikallerin etkilerini önlemek için pek çok savunma sistemi gelişmiştir. Vücudun savunma sistemlerinden birisi de endojen antioksidanlar olarak bilinen; vitamin A(β-karoten), C ve E’dir. Özellikle cıva (Hg), kurşun (Pb), kadmiyum (Cd) ve arsenik (As) gibi ağır metal kirliliği tüm canlıların hayatında tehdit oluşturmaktadırlar. Ağır metallerin toksisitesini belirleyen ortak mekanizma oksidatif stres oluşumudur. Yoğun oksidatif stres oluştuğunda antioksidan savunma yetersiz kalabilir. Bu durumda dokularda kalıcı hasarlar meydana gelir. Bu derlemede ağır metallerin neden olduğu toksisite ve özellikle de serbest radikal oluşumunun önlemede antioksidan vitaminlerin etkileri değerlendirildi.
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Birincil Dil tr
Konular Veteriner Hekimlik
Bölüm Derleme
Yazarlar

Orcid: 0000-0002-6988-2027
Yazar: Canan İRİŞ
Kurum: KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ, VETERİNERLİK BİYOKİMYASI ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0003-3806-9938
Yazar: Miyase ÇINAR (Sorumlu Yazar)
Kurum: KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ, VETERİNERLİK BİYOKİMYASI ANABİLİM DALI
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 30 Aralık 2019

APA İriş, C , Çınar, M . (2019). ANTİOKSİDAN VİTAMİNLER VE AĞIR METAL TOKSİSİTESİ ÜZERİNE ETKİLERİ . Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni , 10 (3) , 135-151 . Retrieved from https://dergipark.org.tr/tr/pub/vetfarmatoksbulten/issue/51046/658274