ANTİOKSİDAN VİTAMİNLER VE AĞIR METAL TOKSİSİTESİ ÜZERİNE ETKİLERİ

Yıl 2019, Cilt: 10 Sayı: 3, 135 - 151, 30.12.2019

Canan İriş , Miyase Çınar

Öz

Vücutta antioksidanlar adıyla bilinen serbest radikallerin etkilerini önlemek için pek çok savunma sistemi gelişmiştir. Vücudun savunma sistemlerinden birisi de endojen antioksidanlar olarak bilinen; vitamin A(β-karoten), C ve E’dir. Özellikle cıva (Hg), kurşun (Pb), kadmiyum (Cd) ve arsenik (As) gibi ağır metal kirliliği tüm canlıların hayatında tehdit oluşturmaktadırlar. Ağır metallerin toksisitesini belirleyen ortak mekanizma oksidatif stres oluşumudur. Yoğun oksidatif stres oluştuğunda antioksidan savunma yetersiz kalabilir. Bu durumda dokularda kalıcı hasarlar meydana gelir. Bu derlemede ağır metallerin neden olduğu toksisite ve özellikle de serbest radikal oluşumunun önlemede antioksidan vitaminlerin etkileri değerlendirildi.

Anahtar Kelimeler

Ağır metaller, Antioksidan vitaminler, Oksidatif stres

ANTIOXIDANT VITAMINS AND ITS EFFECTS ON HEAVY METAL TOXICITY

Öz

Many defense systems known antioxidants have been developed in the body to prevent the effects of free radicals. One of the body's defense systems is endogenous antioxidants; vitamins A (β-carotene), C and E . Especially heavy metal pollution such as mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) poses a threat to the life of all living things. The common mechanism that determines the toxicity of heavy metals is the formation of oxidative stress. Antioxidant defense may be insufficient when intense oxidative stress occurs. In this review, the effects of antioxidant vitamins in toxicity caused by heavy metals and especially in the prevention against free radical formation were evaluated.

Anahtar Kelimeler

Antioxidants vitamins, Heavy metals, Oxidative stress

Kaynakça

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