SİTOKİNLER VE KANATLILARDA SİTOKİNLERİN AŞI ADJUVANTI OLARAK KULLANIMI

Yıl 2021, Cilt: 12 Sayı: 1, 21 - 32, 07.05.2021

Aziz Utku Önel Murat Yıldırım

https://doi.org/10.38137/vftd.897776

Öz

Kanatlı hayvanlarda hastalıkların önlenmesi ve sağaltımı aşıların ve antibiyotiklerin kullanılması ile sağlanır. Antibiyotiklerin uzun yıllar boyunca kullanılması antibiyotiğe dirençli bakterilerin ortaya çıkması ile ilgili sorunları beraberinde getirmiştir. Hastalıkların önlenmesinde kullanılan aşılardaki adjuvantlar, sağlık üzerinde yan etkilere sahip olabilir ve immun yanıtı yetersiz bir şekilde uyarabilir. Bu nedenle kanatlı endüstrisinde yeni aşı stratejilerinin geliştirilmesi oldukça önemli bir konu haline gelmiştir. Sitokinler, yangı reaksiyonlarında hayati rol oynayan hücreler tarafından salgılanan immun sistem hücrelerinin aktivasyonu ve düzenlenmesini sağlayan peptitlerdir. Kanatlı immunolojisi ve genetik alanındaki gelişmeler, özellikle tavukta çeşitli sitokinlerin keşfedilmesine ve bu sitokinlerin işlevsel özelliklerinin ve mekanizmalarının anlaşılmasını sağlamıştır. Kanatlı hayvanlarda enfeksiyöz ajanlara karşı kullanılan aşılarda sitokinlerin potansiyel bir aşı adjuvantı olarak kullanılması yönünde birçok çalışma gerçekleştirilmiştir. Bu derlemede kanatlı sitokinlerinin çeşitleri, fonksiyonel özellikleri ve sitokinlerin aşı adjuvantı olarak kullanımı hakkında bilgi vermek amaçlandı.

Anahtar Kelimeler

Adjuvant, aşı, kanatlı immunolojisi, sitokin

CYTOKINES AND THE USE OF CYTOKINES AS VACCINE ADJUVANT IN POULTRY

Öz

Prevention and treatment of diseases in poultry is provided by the use of vaccines and antibiotics. The use of antibiotics for many years has brought problems with the emergence of antibiotic-resistant bacteria. Adjuvants in vaccine used in the prevention of diseases may have adverse health effects and may inadequately stimulate the immune response. Therefore, the development of new vaccine strategies has become a crucial issue in the poultry industry. Cytokines are peptides that enable the activation and regulation of immune system cells secreted by cells that play a vital role in inflammation reactions. Avian immunology and genetic components have led to the discovery of various cytokines, especially in chicken and to understand the functional properties and mechanisms of these cytokines. Many studies have been conducted on the use of cytokines as a potential vaccine adjuvant in vaccines used against infectious agents in poultry. In this review, we aimed to give information about the types and functional properties of avian cytokines and the use of cytokines as vaccine adjuvants.

Anahtar Kelimeler

Adjuvant, avian immunology, cytokines, vaccine

Kaynakça

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