STEM CELL PRODUCTION, ISOLATION AND THEIR USES IN TREATMENT

Yıl 2021, Cilt: 12 Sayı: 2, 55 - 78, 11.09.2021

Muhammet Mükerrem Kaya Hidayet Tutun

https://doi.org/10.38137/vftd.969798

Öz

Stem cells are the basic cells that form all tissues and organs of multicellular organisms. Stem cells have become an alternative therapy option in the treatment of various illnesses with the ability to repair damaged cells or regenerate organs. In recent years, there has been a tremendous increase in the understanding of stem cell biology and clinical applications in the treatment of diseases. Todays, stem cells have been used for therapeutic purposes alongside traditional treatment in the world. Although significant advances in stem cell biology, ethical debates regarding embryonic stem cells, tumorigenesis and rejection limit their use. The successful results in the use of stem cells have made it a new treatment strategy in diseases. It is expected that the development of stem cell technology will contribute to establishment the of tissue banks obtained from stem cells with different usage areas and to a personalized treatment strategy in the near future. This review focuses on the definition, origin and classification of stem cells and their applications in regenerative medicine.

Anahtar Kelimeler

Stem Cell, Regenerative Medicine, Therapy

KÖK HÜCRE ÜRETİMİ, İZOLASYONU VE TEDAVİDE KULLANIMI

Öz

Kök hücreler, çok hücreli canlıların bütün doku ve organlarını oluşturan temel hücrelerdir. Mitoz bölünme ile farklı hücre ve doku tiplerine farklılaşma ve çoğalma yeteneğine sahiplerdir. Kök hücrelerin hasarlı hücreleri değiştirme veya organları yenileme yetenekleri bazı hastalıkların tedavisinde alternatif bir tedavi seçeneği olmasını sağlamıştır. Kök hücre biyolojisinin anlaşılması ve hastalıkların tedavisinde klinik uygulamalar üzerine yoğun çalışmalar yapılmaktadır. Son yıllarda özellikle kişiye özel tedavi seçeneklerinin ön plana çıktığı çalışmalar göze çarpmaktadır. Kök hücre biyolojisinde önemli ilerlemelere rağmen, embriyonik kök hücrelerle etik tartışmalar, tümör oluşumu ve doku reddi gibi konular bunların kullanımını sınırlandırmaktadır. Kök hücre teknolojisinin gelişmesiyle yakın gelecekte farklı alanlarda kullanılabilen kök hücrelerle elde edilen doku bankalarının oluşturulması ve kişiye özel tedavi stratejisine katkı sağlaması beklenmektedir. Bu derleme, kök hücre tanımı, kökeni ve sınıflandırılması ile bu hücrelerin rejeneratif tıptaki uygulamaları üzerine odaklanır.

Anahtar Kelimeler

Kök hücre, Rejeneratif tıp, Tedavi

Kaynakça

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