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HAYVANLARDA İMIDOKARB KULLANIMI

Yıl 2022, Cilt: 13 Sayı: 2, 120 - 131, 31.08.2022
https://doi.org/10.38137/vftd.1141522

Öz

İmidokarb dipropionat karbanilid türevi antiprotozoon ilaçtır. İlacın hayvanlarda kullanımı kenelerle nakledilen babesiosis (piroplasmosis) ve anaplasmosis tedavisinde onaylanmıştır. Ancak kenelerle nakledilen diğer bazı mikroorganizmalara etkinliği de araştırılmıştır. Sığır, at, eşek, katır, köpek ve koyunlar hedef türler olarak tanımlanmakla birlikte, diğer evcil ve yabani hayvanlarda da kullanılabilmektedir. İlacın tek doz olarak kullanımı önerilmekle birlikte, gerektiğinde 2-3 gün sonra uygulama yapılabilir. İlacın terapötik indeksi dardır ve dozaj rejimine dikkat edilmelidir. Bu derlemede imidokarbın hayvan türlerinde kullanımı, tedavide başarısı ve yan etkileri hakkında bilgiler verilmeye çalışılmıştır.

Destekleyen Kurum

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Proje Numarası

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Teşekkür

Prof. Dr. Enver Yazar'a teşekkür ederiz.

Kaynakça

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IMIDOCARB USE IN ANIMALS

Yıl 2022, Cilt: 13 Sayı: 2, 120 - 131, 31.08.2022
https://doi.org/10.38137/vftd.1141522

Öz

Imidocarb dipropionate is a carbanilide derivative antiprotozoan drug. The drug is approved for use in animals for the treatment of tick-borne transmitted babesiosis (piroplasmosis) and anaplasmosis. However, its effectiveness against some other microorganisms transmitted by ticks has also been investigated. Although cattle, horses, donkeys, mules, dogs and sheep are defined as target species, they can also be used in other domestic and wild animals. Although it is recommended to use the drug as a single dose, it can be applied 2-3 days later if necessary. The therapeutic index of the drug is narrow, and attention should be paid to the dosage regimen. In this review, it could be tried to give information about the use of imidocarb in animal species, its success in treatment and its side effects.

Proje Numarası

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Kaynakça

  • Abdullah, A. S., Sheikh-Omar, A. R., Baggot, J. D. & Zamri, M. (1984). Adverse effects of imidocarb dipropionate (Imizol®) in a dog. Veterinary Research Communications, 8 (1), 55-59.
  • Abdullah, A. S. & Baggot, J. D. (1986). Influence of induced disease states on the disposition kinetics of imidocarb in goats. Journal of Veterinary Pharmacology and Therapeutics, 9 (2), 192-197.
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  • Ekici O. D. (2021). Protozoon hastalıkları, in: Merkep (Eşek) El Kitabı, Eds: Çizmeci SÜ, Alaşahan S, Nobel yayınevi, Ankara, Türkiye, pp:125-135.
  • Eddlestone, S. M., Neer, T. M., Gaunt, S. D., Corstvet, R., Gill, A., Hosgood, G., Hegarty, B. & Breitschwerdt, E. B. (2006). Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs. Journal of Veterinary Internal Medicine, 20 (4), 840-844.
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  • Esmaeilnejad, B., Dalir-Naghadeh, B., Tavassoli, M., Asri-Rezaei, S., Mahmoudi, S., Rajabi, S., Aligolzadeh, A., Akbari, H. & Morvaridi, A. (2021). Assessment of hepatic oxidative damage, paraoxonase-1 activity, and lipid profile in cattle naturally infected with Babesia bigemina. Tropical Animal Health and Production, 53 (2), 1-8.
  • França, R. T., Da Silva, A. S., Paim, F. C., Costa, M. M., Soares, J. F., Mazzanti, C. M. & dos Anjos Lopes, S. T. (2010). Rangelia vitalli in dogs in southern Brazil. Comparative Clinical Pathology, 19 (4), 383-387.
  • Gray, J. S. & Potgieter, F. T. (1981). The retention of Babesia bigemina infections by Boophilus decoloratus exposed to imidocarb dipropionate during engorgement. Onderstepoort Journal of Veterinary Research, 48 (4), 225-227.
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  • Irizarry‐Rovira, A. R., Stephens, J., Christian, J., Kjemtrup, A., DeNicola, D. B., Widmer, W. R. & Conrad, P. A. (2001). Babesia gibsoni infection in a dog from Indiana. Veterinary Clinical Pathology, 30 (4), 180-188.
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  • Jiménez-Meléndez, A., Rico-San Román, L., Hemphill, A., Balmer, V., Ortega-Mora, L. M. & Álvarez-García, G. (2018). Repurposing of commercially available anti-coccidials identifies diclazuril and decoquinate as potential therapeutic candidates against Besnoitia besnoiti infection. Veterinary Parasitology, 261, 77-85.
  • Kock, N. & Kelly, P. (1991). Massive hepatic necrosis associated with accidental imidocarb dipropionate toxicosis in a dog. Journal of Comparative Pathology, 104 (1), 113-116.
  • Kumar, S., Gupta, A. K., Pal, Y. & Dwivedi, S. K. (2003). In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys. Journal of Veterinary Medical Science, 6 5(11):1171-1177.
  • Legroux, J. P., Halos, L., Rene-Martellet, M., Servonnet, M., Pingret, J. L., Bourdoiseau, G., Baneth, G. & Chabanne, L. (2017). First clinical case report of Cytauxzoon sp. infection in a domestic cat in France. BMC Veterinary Research, 13 (1), 1-7.
  • Lewis, B. D., Penzhorn, B. L. & Volkmann, D. H. (1999). Could treatment of pregnant mares prevent abortions due to equine piroplasmosis? Journal of the South African Veterinary Association, 70 (2), 90-91.
  • Lilliehöök, I., Tvedten, H. W., Pettersson, H. K. & Baneth, G. (2019). Hepatozoon canis infection causing a strong monocytosis with intra‐monocytic gamonts and leading to erroneous leukocyte determinations. Veterinary Clinical Pathology, 48 (3), 435-440.
  • Marchetti, V., Lubas, G., Baneth, G., Modenato, M. & Mancianti, F. (2009). Hepatozoonosis in a dog with skeletal involvement and meningoencephalomyelitis. Veterinary Clinical Pathology, 38 (1), 121-125.
  • Marco, I., Velarde, R., Castellà, J., Ferrer, D. & Lavı́n, S. (2000). Presumptive Babesia ovis infection in a spanish ibex (Capra pyrenaica). Veterinary Parasitology, 87 (2-3), 217-221.
  • Máthé, A., Vörös, K., Papp, L. & Reiczigel, J. (2006). Clinical manifestations of canine babesiosis in Hungary (63 cases). Acta Veterinaria Hungarica, 54 (3), 367-385.
  • Máthé, A., Dobos-Kovács, M. & Vörös, K. (2007). Histological and ultrastructural studies of renal lesions in Babesia canis infected dogs treated with imidocarb. Acta Veterinaria Hungarica, 55 (4), 511-523.
  • McHardy, N., Woollon, R. M., Clampitt, R. B., James, J. A. & Crawley, R. J. (1986). Efficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheep. Research in Veterinary Science, 41 (1), 14-20.
  • McInnes, E. F., Stewart, C. G., Penzhorn, B. L. & Meltzer, D. G. (1991). An outbreak of babesiosis in imported sable antelope (Hippotragus niger) (abstract). Journal of the South African Veterinary Association, 62 (1), 30-32.
  • Mehlhorn, H. & Schein, E. (1998). Redescription of Babesia equi Laveran, 1901 as Theileria equi Mehlhorn, Schein 1998. Parasitology Research, 84 (6), 467-475.
  • Meyer, C., Guthrie, A. J. & Stevens, K. B. (2005). Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate. Journal of the South African Veterinary Association, 76 (1), 26-32.
  • Milnes, E.L., Delnatte, P., Woodbury, M., Hering, A., Lee, S., Smith, D.A., Nemeth, N.M., Gu, Y., Gehring, R. & Johnson, R. (2020). Pharmacokinetics of imidocarb dipropionate in white-tailed deer (Odocoileus virginianus) after single intramuscular administration. Journal of Veterinary Pharmacology and Therapeutics, 43 (1), 33-37.
  • Mishra, A. K. & Sharma, N. N. (1979). Comparative efficacy of drugs in bovine anaplasmosis. Tropical Animal Health and Production, 11 (1), 222-226.
  • MSD. (2022). https://vetrehberi.com/imidovil/, Accessed at: 19.05.22.
  • Mylonakis, M. E., Koutinas, A. F., Baneth, G., Polizopoulou, Z. & Fytianou, A. (2004). Mixed Ehrlichia canis, Hepatozoon canis, and presumptive Anaplasma phagocytophilum infection in a dog. Veterinary Clinical Pathology, 33 (4), 249-251.
  • Naor, A. W., Lindemann, D. M., Schreeg, M. E., Marr, H. S., Birkenheuer, A. J., Carpenter, J. W. & Ryseff, J. K. (2019). Clinical, morphological, and molecular characterization of an undetermined Babesia species in a maned wolf (Chrysocyon brachyurus). Ticks and tick-borne diseases, 10 (1), 124-126.
  • Novacco, M., Hofmann-Lehmann, R., Grimm, F., Meli, M. L. & Stirn, M. (2019). Fatal acute babesiosis associated with Babesia venatorum infection (Babesia sp. EU1) in a captive reindeer calf in Switzerland. Veterinary Parasitology: Regional Studies and Reports, 18, 100336.
  • Olukunle, J. O., Oyedoyin, C. T., Jacobs, E. B., Adeleye, E. O., Omobowale, T. O. & Arowolo, R. O. A. (2018). Comparative assessment of the effect of diminazene aceturate and imidocarb dipropionate on haematology and serum biochemical parameters of apparently healthy Nigerian dogs. Egyptian Journal of Veterinary Sciences, 49 (2), 75-81.
  • Panghal, R. S., Rana, R. D. & Vinod, K. (2009). Effects of imidocarb on cholinesterase activity and grossly observable behaviour in dogs. Haryana Veterinarian, 48, 26-28.
  • Pasa, S., Voyvoda, H., Karagenc, T., Atasoy, A. & Gazyagci, S. (2011). Failure of combination therapy with imidocarb dipropionate and toltrazuril to clear Hepatozoon canis infection in dogs. Parasitology Research, 109 (3), 919-926.
  • Phair, K. A., Carpenter, J. W., Smee, N., Myers, C. B. & Pohlman, L. M. (2012). Severe anemia caused by babesiosis in a maned wolf (Chrysocyon brachyurus). Journal of Zoo and Wildlife Medicine, 43 (1), 162-167.
  • Price, J. E. & Dolan, T. T. (1980). A comparison of the efficacy of imidocarb dipropionate and tetracycline hydrochloride in the treatment of canine ehrlichiosis. The Veterinary Record, 107 (12), 275-277.
  • Radyuk, E. & Karan, L. (2020). A case of Babesia vulpes infection in a dog in Russia. Veterinary Parasitology: Regional Studies and Reports, 22, 100467.
  • Rashid, A., Mubarak, A. & Hussain, A. (2009). Babesiosis in equines in Pakistan: a clinical report. Vet Ital, 45 (3), 391-5.
  • Şahal, M., Kar, S., Gazyağcı, S. & Aktaş M. S. (2009). Babesiosis in a cattle during winter season and its treatment with imidocarb dipropionate. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 4 (3), 191-195.
  • Sainz, A., Tesouro, M. A., Amusategui, I., Rodriguez, F., Mazzucchelli, F. & Rodriguez, M. (2000). Prospective comparative study of 3 treatment protocols using doxycycline or imidocarb dipropionate in dogs with naturally occurring ehrlichiosis. Journal of Veterinary Internal Medicine, 14 (2), 134-139.
  • Sarli, M., Novoa, M. B., Mazzucco, M. N., Morel, N., Primo, M. E., de Echaide, S. T. & Echaide, I. E. (2021). Efficacy of long-acting oxytetracycline and imidocarb dipropionate for the chemosterilization of Anaplasma marginale in experimentally infected carrier cattle in Argentina. Veterinary Parasitology: Regional Studies and Reports, 23, 100513.
  • Sasanelli, M., Paradies, P., Greco, B., Eyal, O., Zaza, V. & Baneth, G. (2010). Failure of imidocarb dipropionate to eliminate Hepatozoon canis in naturally infected dogs based on parasitological and molecular evaluation methods. Veterinary Parasitology, 171 (3-4), 194-199.
  • Sato, M., Veir, J. K., Shropshire, S. B. & Lappin, M. R. (2020). Ehrlichia canis in dogs experimentally infected, treated, and then immune suppressed during the acute or subclinical phases. Journal of Veterinary Internal Medicine, 34 (3), 1214-1221.
  • Schwint, O. N., Ueti, M. W., Palmer, G. H., Kappmeyer, L. S., Hines, M. T., Cordes, R. T., Knowles, D. P. & Scoles, G. A. (2009). Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrobial Agents and Chemotherapy, 53 (10), 4327-4332.
  • Sevinc, F., Turgut, K., Sevinc, M., Ekici O. D., Coskun, A., Koc, Y., Erol, M. & Ica, A. (2007). Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. Veterinary Parasitology, 149 (1-2), 65-71.
  • Shen, Y., Gao, J., Xu, K., Xue, L., Zhang, Y., Shi, B., Li, D., Wei, X. & Selichi H. (1997). Babesiasis in Nanjing area, China. Tropical Animal Health and Production, 29 (4), 19S-22S.
  • Simões, P. B., Cardoso, L., Araújo, M., Yisaschar-Mekuzas, Y. & Baneth, G. (2011). Babesiosis due to the canine Babesia microti-like small piroplasm in dogs-first report from Portugal and possible vertical transmission. Parasites & Vectors, 4 (1), 1-6.
  • Ulusan, M., Varol, K., Ekinci, G., Çakır Bayram, L., Keleş, İ., Onmaz, A. C. & Güneş, V. (2016). Bir koyun sürüsünde imidokarb uygulamasına bağlı kalp kası hasarının biyobelirteçler ışığında değerlendirilmesi: 5 vaka. Kocatepe Veterinary Journal, 9 (2), 135-139.
  • Uslu, M., Canbar, R. & Yazar, E. (2021). Genel tedavi, in: Merkep (Eşek) El Kitabı, Eds: Çizmeci SÜ, Alaşahan S, Nobel yayınevi, Ankara, Türkiye, pp:147-172.
  • Xaxa, L. S. & Kumar, P. (2018). Therapeutic management of E. canis in dog. International Journal of Current Microbiology and Applied Sciences, 7, 3335-3339.
  • Yan, Z., Liu, J., Chen, T., Cheng, Z., Guo, H., Wang, Z. & Wang, Y. (2008). Treatment of Mycoplasma wenyonii infection in cows with imidocarb dipropionate injection-acupuncture. Journal of Acupuncture and Meridian Studies, 1 (2), 143-148.
  • Yazar, E. (2018). Veteriner İlaç ve Aşı A’dan Z’ye. Nobel tıp kitabevleri, İstanbul, Türkiye, pp:120-121.
  • Yazar, E. (2021a). Antiprotozoon tedavi, Veteriner İlaç Rehberi ve Tedavi El Kitabı, Ed: Yazar E, Nobel tıp kitabevleri, İstanbul, Türkiye, pp: 216-223.
  • Yazar, E. (2021b). Köpeklerde Tedavi El Kitabı, Nobel tıp kitabevleri, İstanbul, Türkiye, pp:11-12, 86-100.
Toplam 92 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Bilimleri
Bölüm Derleme
Yazarlar

Muhittin Uslu 0000-0002-9027-4229

Rahmi Canbar Bu kişi benim 0000-0001-7100-4437

Proje Numarası -
Yayımlanma Tarihi 31 Ağustos 2022
Kabul Tarihi 22 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 13 Sayı: 2

Kaynak Göster

APA Uslu, M., & Canbar, R. (2022). IMIDOCARB USE IN ANIMALS. Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni, 13(2), 120-131. https://doi.org/10.38137/vftd.1141522