KARDİYOVASKÜLER HASTALIKLARDA GGT

Yıl 2024, Cilt: 15 Sayı: 3, 143 - 149, 31.12.2024

Avni Camgöz , Beyza Suvarıklı Alan , Elif Yilmaz Şahin , Vahdettin Altunok

https://doi.org/10.38137/vftd.1493957

Öz

Hem beşeri hekimlikte hem de veteriner hekimlikte hızlı teşhis oldukça önemlidir. Özellikle veteriner hekimlikte hastanın kendini ifade edememesi, hekimleri farklı teşhis metotlarına yönlendirmektedir. Günümüzde hastalıkların teşhisinde ve uygun tedavi protokolünün hazırlanmasında klinik enzimolojiden sıklıkla yararlanılmaktadır. Çeşitli organ hasarları hakkında bilgi sağlayan enzimler konusunda akla ilk gelen karaciğer enzimleridir. Klinikte, Gamma glutamil transferaz (GGT), Alanin aminotransferaz (ALT) ve Aspartat aminotransferaz (AST) gibi bazı enzim aktivitelerinden sıklıkla yararlanılır. Bu enzimler karaciğer ve safra kanalı hasarlarında oldukça değerlidir. Ek olarak hem AST hem de GGT enzim aktivitelerinin kardiyovasküler hastalıklar gibi hayati önemi bulunan durumlarda da hekimleri teşhise yönlendirebileceği düşüncesi konuyu daha değerli hale getirmektedir. Bu enzim aktivitelerinin karaciğer dışındaki organlarda meydana gelen hasar durumlarında değişmesi araştırmacıların ilgisini çekmiştir. Gamma glutamil transferaz enzim aktivitesinin sadece karaciğer hasarında değil, çeşitli organ hasarlarında ve özellikle kalp hasarlarında kullanılabilirliği fikri giderek artmaktadır. Bu konuda oldukça önem kazanan GGT enzim aktivitesinin kalp hasarındaki konumu hakkında çalışmalar devam etmektedir. Yakın gelecekte GGT enzim aktivitesinin kardiyovasküler hastalıkların teşhisinde rutin olarak kullanılması olasıdır. Bu derlemede, GGT enzim aktivitesi ile diğer karaciğer enzim aktivitelerinin organizmadaki rolü, yaygınlığı, hastalıklarla olan ilişkisi, GGT’ın glutatyon olarak bilinen γ-glutamil-sisteinil-glisin (GSH) metabolizmasına sağladığı katkı, oksidatif stresteki rolü, kardiyovasküler hastalıklarla ilişkisi ve teşhis aşamasıdaki önemi gibi konulara değinilmektedir.

Anahtar Kelimeler

Göz, ilaç, kedi, köpek, kulak

GGT IN CARDIOVASCULAR DISEASES

Öz

Rapid diagnosis is very important both in human medicine and veterinary medicine. Especially in veterinary medicine, the patient's inability to express themselves leads physicians to different diagnostic methods. Today, clinical enzymology is frequently utilized in the diagnosis of diseases and in the preparation of appropriate treatment protocols. When it comes to enzymes that provide information about various organ damage, liver enzymes are the first to come to mind. Some enzyme activities such as Gamma glutamyl transferase (GGT), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) are frequently utilised in the clinic. These enzymes are valuable in liver and bile duct damage. In addition, the idea that both AST and GGT enzyme activities can lead physicians to diagnose vital conditions such as cardiovascular diseases makes the subject more valuable. Changes in these enzyme activities in damage conditions occurring in organs other than the liver have attracted the attention of researchers. The idea that GGT enzyme activity can be used not only in liver damage but also in various organ damage and especially in cardiac damage is increasing. Studies on the position of GGT enzyme activity, which has become very important in this regard, in cardiac damage are ongoing. It is likely that in the near future GGT enzyme activity will be routinely used in the diagnosis of cardiovascular diseases. In this review, the role of GGT enzyme activity and other liver enzyme activities in the organism, its prevalence, its relationship with diseases, the contribution of GGT to γ-glutamyl-cysteinyl-glycine (GSH) metabolism known as glutathione, its role in oxidative stress, its relationship with cardiovascular diseases and its importance in the diagnostic stage are discussed.

Anahtar Kelimeler

Cat, dog, drug, ear, eye

Kaynakça

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