SMART DRUGS AND CANCER TREATMENT

Yıl 2024, Cilt: 15 Sayı: 3, 120 - 126, 31.12.2024

Çağlar Okulmuş , Alparslan Kadir Devrim , Tuba Devrim

https://doi.org/10.38137/vftd.1515882

Öz

Cancer is an uncontrollable growth and development of cells in the body and one of the biggest reasons for death on a global scale. Despite the progress made in the understanding of cancer mechanisms, the strategies based on research are still at an incipient stage and the conventional treatments, mainly chemotherapy, remain the most widespread form of cancer treatment. However, these conventional therapies have several drawbacks, such as off-target effects, drug resistance, toxicity, and poor bio-availability of drugs to tumor tissue. Smart drugs and nanostructured drug delivery vehicles have been generally applied for cancer therapy due to improvements in medicine and technology to solve these such limitations of cancer treatment. Therefore, smart drugs offer more effective and less side-effect treatment for cancer compared to conventional therapies. In this review, we aimed to examine smart drugs, which have been increasingly used in cancer treatment in recent years.

Anahtar Kelimeler

Cancer, nanotechnology, smart drug

AKILLI İLAÇ VE KANSER TEDAVİSİ

Öz

Kanser, vücuttaki hücrelerin kontrol edilemeyen bir şekilde büyümesi ve gelişmesidir ve küresel ölçekte ölümlerin en büyük nedenlerinden biridir. Kanser mekanizmalarının anlaşılmasında kaydedilen ilerlemeye rağmen, araştırmaya dayalı stratejiler hala başlangıç aşamasındadır ve başta kemoterapi olmak üzere geleneksel tedaviler kanser tedavisinin en yaygın şekli olmaya devam etmektedir. Bununla birlikte, bu geleneksel tedavilerin hedef dışı etkiler, ilaç direnci, toksisite, ilaçların tümör dokusuna biyoyararlanımının zayıf olması gibi çeşitli dezavantajları vardır. Kanser tedavisinin bu tür sınırlamalarını çözmek için tıp ve teknolojideki gelişmeler nedeniyle akıllı ilaçlar ve nanoyapılı ilaç dağıtım araçları genellikle kanser tedavisi için uygulanmaktadır. Bu nedenle, akıllı ilaçlar geleneksel tedavilere kıyasla kanser için daha etkili ve daha az yan etkili bir tedavi sunmaktadır. Bu derlemede, son yıllarda kanser tedavisinde kullanımı giderek artan akıllı ilaçları incelemeyi amaçladık.

Anahtar Kelimeler

Akıllı ilaç, kanser, nanoteknoloji

Kaynakça

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