EFFECTS OF THYROID HORMONES ON METABOLISM AND THE ROLE OF DEIODINASE ENZYMES

Yıl 2024, Cilt: 15 Sayı: 3, 113 - 119, 31.12.2024

Burak Can Ayan , Dünya Yavuzoğlu

https://doi.org/10.38137/vftd.1529416

Öz

The effects of thyroid hormones on carbohydrate, protein and lipid metabolism have been extensively investigated over the years and their effects on metabolism are particularly significant in lipid metabolism. Tissue-specific deiodinase (DIO) enzymes are involved in the regulation of these effects. These deiodinase enzymes can be found in tissues in the form of DIO1, DIO2 and DIO3 and contribute to the regulation of the progress, level and metabolism of thyroid hormones in the target tissues by making them active or inactive. In this review, we aimed to investigate which deiodinase enzyme activates or inactivates thyroid hormones in liver, pancreas, brown adipose tissue, white adipose tissue, hypothalamus and skeletal muscle and how these processes affect metabolism.

Anahtar Kelimeler

Deiodinase, enzyme, metabolism, thyroid

TİROİD HORMONLARININ METABOLİZMA ÜZERİNDEKİ ETKİLERİ VE DEİYODİNAZ ENZİMLERİNİN ROLÜ

Öz

Tiroit hormonlarının karbonhidrat, protein ve lipid metabolizması üzerindeki etkileri yıllar boyunca kapsamlı bir şekilde araştırılmıştır ve bu hormonların metabolizma üzerindeki etkileri ve özellikle de lipid metabolizmasında önemli bir yer tutar. Bu etkilerin düzenlenmesinde öncü olan dokularda farklı deiyodinaz (DIO) enzimleri görev alır. Bu deiyodinaz enzimleri; DIO1, DIO2 ve DIO3 şeklinde dokularda var olmasıyla beraber tiroit hormonlarını hedef dokularda aktif veya inaktif hale getirerek bulunduğu dokulardaki seyrinin, seviyesinin ve metabolizmanın düzenlenmesine katkı sağlar. Bu derlemede ise, metabolizma ile ilişkili olan tiroit hormonlarının karaciğerde, pankreasta, kahverengi yağ dokusunda, beyaz yağ dokusunda, hipotalamusta ve iskelet kasında var olan hangi deiyodinaz enzimi tarafından aktive veya inaktive edildiği ve bu süreçlerin metabolizmayı nasıl etkilediğinin araştırılması amaçlanmıştır.

Anahtar Kelimeler

Deiyodinaz, enzim, metabolizma, tiroit

Kaynakça

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