CHICK EMBRYO MODEL IN DEVELOPMENTAL TOXICITY STUDIES

Yıl 2025, Cilt: 16 Sayı: 2, 43 - 52, 31.08.2025

Muhammed Hasan Şirin , Ayhan Filazi

https://doi.org/10.38137/vftd.1609269

Öz

Teratology, which examines congenital anomalies and the factors that cause these anomalies, is a scientific discipline that intersects with developmental toxicology. The evaluation of the potential effects of teratogens on foetal development has become a fundamental prerequisite of preclinical research, particularly in revealing how environmental and chemical factors encountered during the prenatal period affect embryonic development. The chicken embryo model has long been utilized in developmental toxicity research. Among the methods used in preclinical studies, the chicken embryo model offers significant advantages compared to other animal models due to its easy accessibility, low cost, and fewer ethical restrictions.Additionally, the rapid observation of embryonic development represents a key advantage of this model. Moreover, the ability to perform analyses in a controlled environment has established the chicken embryo model as an indispensable tool in scientific studies. With its remarkable similarities to human embryonic development, the chicken embryo model continues to be a powerful tool for understanding embryonic developmental processes. This review aims to emphasize the advantages and limitations of utilizing chicken embryonic models in developmental toxicity testing.

Anahtar Kelimeler

Teratogenicity , Embryotoxicity , Developmental toxicology , In ovo , Chick embryo

GELİŞİMSEL TOKSİSİTE ÇALIŞMALARINDA CİVCİV EMBRİYO MODELİ

Öz

Doğumsal anomalileri ve bu anomalilere neden olan faktörleri inceleyen teratoloji, gelişimsel toksikoloji ile kesişen bir bilim dalıdır. Teratojenlerin fetal gelişim üzerindeki potansiyel etkilerinin değerlendirilmesi özellikle doğum öncesi dönemlerde karşılaşılan çevresel ve kimyasal faktörlerin embriyonik gelişime nasıl etki ettiğini ortaya koymak klinik öncesi araştırmaların temel ön koşullarından biri haline gelmiştir. Tavuk embriyosu, gelişimsel toksisite araştırmaları için uzun zamandır kullanılan bir modeldir. Klinik öncesi araştırmalarda kullanılan yöntemler arasında kolay erişilebilirliği, düşük maliyeti ve etik açıdan daha az sınırlayıcı olması nedeniyle diğer hayvan modellerine kıyasla önemli avantajlar sunmaktadır. Ayrıca, Embriyonik gelişimin hızla gözlemlenebilmesi, bu modelin önemli bir avantajıdır. Aynı zamanda analizlerin kontrollü bir ortamda gerçekleştirilebilmesi, civciv embriyo modelini bilimsel çalışmalarda vazgeçilmez bir araç haline getirmiştir. İnsan embriyonik gelişimiyle dikkate değer benzerlikler taşıyan civciv embriyo modeli, embriyonik gelişim süreçlerini anlamak için güçlü bir araç olmaya devam etmektedir. Bu inceleme, gelişimsel toksisite testinde civciv embriyonik modellerinin kullanımını ele alarak avantajlarını ve dezavantajlarını vurgulamayı amaçlamaktadır.

Anahtar Kelimeler

Teratojenite , Embriyotoksisite , Gelişimsel toksikoloji , İn ovo , civciv embriyosu

Kaynakça

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