A rare case of perivulvar hemangiosarcoma in a bitch

Yıl 2024, , 60 - 65, 15.01.2024

Zeynep Günay Uçmak , Gülay Yüzbaşıoğlu Öztürk , İsmail Kırşan , Aslihan Baykal , Ahmet Gülçubuk , Egemen Mahzunlar

https://doi.org/10.33188/vetheder.1329707

Öz

An 11-year old, Rottweiler bitch was presented to the clinic with the complaint of a huge mass protruding from the left side of the vulvar labium. The bitch had been ovariohysterectomized due to the pyometra 2 years ago. The perivulvar mass was surgically removed by using an electrocautery device under general anesthesia. Macroscopically, the pedunculated mass was 20 cm x 25 cm in diameter, capsulated and slightly firm. Histopathological examination revealed that the mass was a hemangiosarcoma originating from the mucosa. Marked anisocytosis and anisokaryosis were noted in microscopic examination. Immunohistochemically, neoplastic cells showed positive staining for von-Willebrand factor-related antigen. On postoperative 3rd and 12th month follow-up protocols, the female dog was in good health condition and no metastases were detected in any organ. In this report, clinical follow-up, histological and immunohistological examination of a rare perivulvar hemangiosarcoma case in a female dog was presented.

Anahtar Kelimeler

Bitch, Hemangiosarcoma, Immunohistochemistry, Perivulvar

Destekleyen Kurum

Yoktur

Proje Numarası

Yoktur

Teşekkür

-

Dişi bir köpekte nadir bir perivulvar hemanjiosarkom olgusu

Öz

Onbir yaşında, Rottweiler ırkı, dişi bir köpek vulvar labiumun sol yanından çıkıntı yapan kitle şikayeti ile kliniğimize getirildi. Köpeğe 2 yıl önce pyometra nedeniyle ovariohisterektomi uygulanmıştı. Genel anestezi altında elektrokoter cihazı kullanılarak perivulvar kitle cerrahi olarak çıkarıldı. Makroskopik olarak 20 cm x 25 cm çapında, kapsüllü ve hafif sert saplı kitle görüldü. Histopatolojik incelemede, kitlenin mukozadan köken alan bir hemanjiyosarkom olduğu saptandı. Mikroskobik incelemede belirgin anizositoz ve anizokaryoz kaydedildi. İmmünohistokimyasal olarak neoplastik hücreler, von-Willebrand faktörü ile ilişkili antijen için pozitif boyanma gösterdi. Operasyon sonrası 3. ve 12. ay takip protokollerinde köpeğin sağlık durumu iyiydi ve herhangi bir organa metastaz göstermedi. Bu olgu sunumunda, dişi bir köpekte nadir görülen bir perivulvar hemanjiyosarkom olgusunun klinik takibi, histolojik ve immünohistolojik bulguları sunulmuştur.

Anahtar Kelimeler

Hemanjiosarkom, Immunohistokimya, Dişi Köpek, Perivulvar

Proje Numarası

Yoktur

Kaynakça

• Weiss E. Tumours of the soft (mesenchymal) tissues. Bull. World Health Organ 1974; 50: 101-110.
• Clifford CA, Mackin AJ, Henry CJ. Treatment of canine hemangiosarcoma: 2000 and beyond. J. Vet. Intern. Med 2000; 14: 479–485.
• Clendaniel DC, Sivacolundhu RK, Sorenmo KU, Donovan TA, Turner A, Arteaga T, et al. Association between macroscopic appearance of liver lesions and liver histology in dogs with splenic hemangiosarcoma: 79 cases (2004−2009). J. Am Anim Hosp Assoc 2014; 50: e6–e10.
• Brown NO. Hemagiosarcomas. Vet. Clin. North Am. Small Anim 1985; 15(3): 569-575.
• Yoo S, Kim J, Myung HW, Woo S, Chung DJ, Lee AJ, et al. Primary intrapelvic hemangiosarcoma in a dog. J. Vet. Med. Sci 2017; 79(1): 192–196.
• Nielssen A. Hemangiosarcoma. In: Rubin SI, Carr AP, editors. Canine Internal Medicine Secrets. St Louis Missouri (USA): Mosby; 2007. p. 370-372.
• Hendrick, M.J. Mesenchymal tumors of the skin and the soft tissues. In: Meuten DJ, editor. Tumors in domestic animals. 5th ed. NewYork (USA): John Wiley & Sons; 2020. p.162.
• Torres de la Riva G, Hart BL, Farver TB, Oberbauer AM, McV Messam LL, Willits N, et al. Neutering dogs: Effects on joint disorders and cancers in golden retrievers. PloS One 2013; 8: e55937.
• Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. JAVMA 2014; 244: 309–319.
• Ware WA, Hopper DL. Cardiac tumors in dogs: 1982–1995. J. Vet Intern Med. 1999; 13: 95–103.
• Azizi S, Amirmohammadi M, Kheirandish R, Davoodian Z, Goodarzi M. Occurrence of haemangiosarcoma on the gingiva of a calf: a case report. Bulg J Vet Med 2017; 20: 183-188.
• von Beust BR, Suter MM, Summers BA. Factor VIII-related antigen in canine endothelial neoplasms: an immunohistochemical study. Vet Pathol 1988; 25(4): 251-255.
• Valli VE, Bienzle D, Meuten DJ, Linder KE. Tumors of the hemolymphatic system. In: Meuten DJ, editor. Tumors in Domestic Animals. NewYork (USA): John Wiley & Sons Edition; 2020. p. 203-320.
• Hill TP, Lobetti RG, Schulman ML. Vulvovaginectomy and neo-urethrostomy for treatment of haemangiosarcoma of the vulva and vagina. J S Afr Vet Assoc 2000; 71(4): 256–259.
• Stephan F, Sharun K, Varghese E, Hamza P, George AJ. Vulvar and vestibulovaginal hemangiosarcoma in a cow: morphological and histopathological observations. Iran J. Vet. Res. 2022; 23(4): 375–379.
• Gumber S, Baia P, Wakamatsu N. Vulvar epithelioid hemangiosarcoma with solar elastosis in a mare. J. Vet. Diagn. Invest. 2011; 23(5): 1033-1036.
• Gülbahar MY, Güvenç T, Beşalti Ö. Splenic hemangiosarcoma with abdominal dissemination in a dog. Turkish J. Vet. Anim. Sci. 1998; 22(5): 459-464.
• Sorenmo K, Duda L, Barber L, Cronin K, Sammarco C, Usborne A, et al. Canine hemangiosarcoma treated with standard chemotherapy and minocycline. J. Vet. Intern. Med. 2000; 14(4): 395–398.
• Batschinski K, Nobre A, Vargas-Mendez E, Tedardi MV, Cirillo J, et al. Canine visceral hemangiosarcoma treated with surgery alone or surgery and doxorubicin: 37 cases (2005-2014). Can Vet J 2018; 59(9): 967–972.