The effect of beta-hydroxybutyrate level on other metabolic test parameters

Öz

Metabolic profile test was performed to determine the metabolic status of dairy cattle and to use in the early diagnosis of metabolic diseases. The aim of this study was to determine the changes in metabolic profile test parameters of dairy cattle with negative energy balances and the relationships between these parameters. The metabolic profile results of 189 cattle within the first 2 wk of lactation period were evaluated retrospectively. Animals with a Beta-hydroxybutyrate (BHBA) threshold level above 1 mmol/L were assigned to Group-1 and the animals with blood BHBA levels less than 1 mmol/L to Group-2. BHBA level was assessed by blood ketone meter. Glucose, blood urea nitrogen (BUN), magnesium (Mg), aspartate aminotransferase (AST), phosphorus (P), cholesterol, total protein, albumin, calcium and gamma glutamyl transferase (GGT) analyzes were performed by the auto-analyzer. Group-1 levels of glucose (p<0.001) and albumin (p<0.01) were found to be significantly lower, GGT (p<0.001), AST (p<0.05), and calcium (p<0.01) were significantly higher than Group-2. BHBA level was found to be negatively correlated with glucose (p<0.01) and with a positive correlation with AST (p<0.01) and GGT (p<0.01). In conclusion, the enzymes showing liver damage started to increase when BHBA value was above 1 mmol/L. In addition to the treatment of the negative energy balance in the cattle with subclinical ketosis, it was concluded that supportive therapies for the liver should be performed and check the risk of the fatty liver in herd.

Anahtar Kelimeler

• Metabolic profile,beta-hydroxybutyrate,cattle

Beta hidroksi bütirik asit düzeyinin diğer metabolik test parametreleri üzerine etkisi

Öz

Metabolik profil test, süt sığırlarının metabolik durumlarını ortaya koymak ve metabolizma hastalıklarının erken tanısına yardımcı olmak amacıyla yapılan bir testtir. Bu çalışmada, negatif enerji dengesizliği olan sütçü sığırların metabolik profil test parametrelerindeki değişimlerin ve bu parametreler arasındaki ilişkilerin ortaya konulması amaçlandı. Çalışma, laktasyon döneminin ikinci haftasında olan 189 adet sığır serum örneğinin metabolik profil test sonuçları retrospektif olarak değerlendirilerek yapıldı. Kan beta hidroksi butirik asit (BHBA) seviyesi 1 mmol/L’nin üstünde olan hayvanlar Grup-1’e, 1 mmol/L'den düşük olan hayvanlar ise Grup-2’ye dahil edildi. BHBA düzeyi keton ölçüm cihazı ile yapıldı. Glikoz, kan üre azotu (BUN), magnezyum (Mg), aspartat aminotransferaz (AST), fosfor (P), kolesterol, total protein, albümin, kalsiyum, gama glutamil transferaz (GGT) analizleri otoanalizör ile yapıldı. Grup-1'in glikoz (p<0,001) ve albümin (p<0,01) düzeylerinin Grup-2'den anlamlı derecede düşük, GGT (p<0,001), AST (p<0,05) ve kalsiyum (p<0,01) düzeylerinin ise Grup-2'den anlamlı derecede yüksek olduğu tespit edildi. BHBA düzeyinin glikoz (p<0,01) ile negatif, AST (p<0,01) ve GGT (p<0,01) ile pozitif korelasyon gösterdiği belirlendi. Sonuç olarak BHBA değeri 1 mmol/L ve üzerine çıktığı durumlarda karaciğer ile ilişkili hasarı gösteren enzimlerin de artmaya başladığı gözlendi. Subklinik ketozis tespit edilen sürülerde negatif enerji dengesinin ortadan kaldırılmasının yanında karaciğer destekleyici tedavilerin verilmesi ve sürünün karaciğer yağlanma riski için kontrol edilmesinin de önemli olduğu kanısına varıldı.    

Anahtar Kelimeler

• metabolik,beta hidroksi butirik asit,sığır

Kaynakça

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