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Ewing Sarkom in Femur Diaphysis and Literature Review

Yıl 2021, Cilt: 2 Sayı: 1, 23 - 26, 25.04.2021
https://doi.org/10.51261/yiu.2021.00023

Öz

Ewing sarcoma is one of the most common malignant tumors in the first two decades after osteosarcoma. With the recent systemic multiagent chemotherapy agents, there has been a significant decrease in mortality and recurrence rates. Ewing sarcoma usually involves the diaphyseal region of long bones. Many methods have been described in the literature regarding the treatment of bone defects after bone resections in this region. The young age of the patients revealed that the biological treatment option should be at the forefront. In this case, we reconstructed the bone defect in the femur with a non-vascularized fibular graft.

Kaynakça

  • Bülbül B, Ellı̇ M, Dağdemı̇r A, Dabak N, Acar S, Barış S, et al. Çocukluk Çağı Ewing Sarkomlu Olguların Retrospektif Değerlendirilmesi. J Exp Clin Med 2011;27:66–72. https://doi.org/10.5835/jecm.omu.27.02.007
  • Atalay İ. Prognostic Factors Affecting the Treatment of Ewing Sarcomas; 2008.
  • Enneking WF. Muskuloskeletal Tumor Surgery. EWING’s Sarcoma, Volume 2. New York: Churchill Livingstone; 1983; pp.1345–1380.
  • Sluga M, Windhager R, Lang S, Heinzl H, Krepler P, Mittermayer F, et al. A long-term review of the treatment of patients with Ewing’s sarcoma in one institution. Eur J Surg Oncol 2001;27:569–573. https://doi.org/10.1053/ ejso.2001.1164
  • Ozaki T. Diagnosis and treatment of Ewing sarcoma of the bone: a review article. J Orthop Sci 2015;20:250–263. https://doi.org/10.1007/s00776-014- 0687-z
  • Ross KA, Smyth NA, Murawski CD, Kennedy JG. The biology of ewing sarcoma. ISRN Oncol 2013;2013:759725. https://doi.org/10.1155/2013/759725
  • Burchill SA. Ewing’s sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. J Clin Pathol 2003;56:96–102. https:// doi.org/10.1136/jcp.56.2.96
  • Aldlyami E, Abudu A, Grimer RJ, Carter SR, Tillman RM. Endoprosthetic replacement of diaphyseal bone defects. Long-term results. Int Orthop 2005;29:25–29. https://doi.org/10.1007/s00264-004-0614-6
  • Abudu A, Carter SR, Grimer RJ. The outcome and functional results of diaphyseal endoprostheses after tumour excision. J Bone Joint Surg Br 1996;78:652–657. https://doi.org/10.1302/0301-620x.78b4.0780652
  • El-Gammal TA, El-Sayed A, Kotb MM. Reconstruction of lower limb bone defects after sarcoma resection in children and adolescents using free vascularized fibular transfer. J Pediatr Orthop B 2003;12:233–243. https:// insights.ovid.com/pubmed?pmid=12821839
  • Hsu RW, Wood MB, Sim FH, Chao EY. Free vascularised fibular grafting for reconstruction after tumour resection. J Bone Joint Surg Br 1997;79:36–42. https://doi.org/10.1302/0301-620X.79B1.0790036
  • Biau DJ, Pannier S, Masquelet AC, Glorion C. Case report: reconstruction of a 16-cm diaphyseal defect after Ewing’s resection in a child. Clin Orthop Relat Res 2009;467:572–577. https://doi.org/10.1007/s11999-008-0605-9
  • Ozaki T, Hillmann A, Bettin D, Wuisman P, Winkelmann W. Intramedullary, antibiotic-loaded cemented, massive allografts for skeletal reconstruction 26 cases compared with 19 uncemented allografts. Acta Orthop Scand 1997;68:387–391. https://doi.org/10.3109/17453679708996183

Femur Diafizinde Ewing Sarkom ve Literatür İncelemesi

Yıl 2021, Cilt: 2 Sayı: 1, 23 - 26, 25.04.2021
https://doi.org/10.51261/yiu.2021.00023

Öz

Ewing sarkom osteosarkom sonrası ilk iki dekatta en çok gözlenen malign tümörlerden bir tanesidir. Son zamanlardaki sistemik multi-ajan kemoterapi ajanları ile birlikte mortalite oranlarında ve nüks oranlarında belirgin oranda düşüş saptanmıştır. Ewing sarkom genellikle uzun kemiklerin diafizer bölgesini sıklıkla tutmaktadır. Bu bölgedeki kemik rezeksiyonları sonrası kemik defektlerinin tedavisi ile ilgili literatürde birçok yöntem tanımlanmıştır. Hastaların genç yaşta olması biyolojik tedavi seçeneğinin ön planda olması gerekliliğini ortaya koymuştur. Biz de bu vakada femurdaki kemik defektini nonvaskülarize fibular greft ile rekonstrükte ettik.

Kaynakça

  • Bülbül B, Ellı̇ M, Dağdemı̇r A, Dabak N, Acar S, Barış S, et al. Çocukluk Çağı Ewing Sarkomlu Olguların Retrospektif Değerlendirilmesi. J Exp Clin Med 2011;27:66–72. https://doi.org/10.5835/jecm.omu.27.02.007
  • Atalay İ. Prognostic Factors Affecting the Treatment of Ewing Sarcomas; 2008.
  • Enneking WF. Muskuloskeletal Tumor Surgery. EWING’s Sarcoma, Volume 2. New York: Churchill Livingstone; 1983; pp.1345–1380.
  • Sluga M, Windhager R, Lang S, Heinzl H, Krepler P, Mittermayer F, et al. A long-term review of the treatment of patients with Ewing’s sarcoma in one institution. Eur J Surg Oncol 2001;27:569–573. https://doi.org/10.1053/ ejso.2001.1164
  • Ozaki T. Diagnosis and treatment of Ewing sarcoma of the bone: a review article. J Orthop Sci 2015;20:250–263. https://doi.org/10.1007/s00776-014- 0687-z
  • Ross KA, Smyth NA, Murawski CD, Kennedy JG. The biology of ewing sarcoma. ISRN Oncol 2013;2013:759725. https://doi.org/10.1155/2013/759725
  • Burchill SA. Ewing’s sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. J Clin Pathol 2003;56:96–102. https:// doi.org/10.1136/jcp.56.2.96
  • Aldlyami E, Abudu A, Grimer RJ, Carter SR, Tillman RM. Endoprosthetic replacement of diaphyseal bone defects. Long-term results. Int Orthop 2005;29:25–29. https://doi.org/10.1007/s00264-004-0614-6
  • Abudu A, Carter SR, Grimer RJ. The outcome and functional results of diaphyseal endoprostheses after tumour excision. J Bone Joint Surg Br 1996;78:652–657. https://doi.org/10.1302/0301-620x.78b4.0780652
  • El-Gammal TA, El-Sayed A, Kotb MM. Reconstruction of lower limb bone defects after sarcoma resection in children and adolescents using free vascularized fibular transfer. J Pediatr Orthop B 2003;12:233–243. https:// insights.ovid.com/pubmed?pmid=12821839
  • Hsu RW, Wood MB, Sim FH, Chao EY. Free vascularised fibular grafting for reconstruction after tumour resection. J Bone Joint Surg Br 1997;79:36–42. https://doi.org/10.1302/0301-620X.79B1.0790036
  • Biau DJ, Pannier S, Masquelet AC, Glorion C. Case report: reconstruction of a 16-cm diaphyseal defect after Ewing’s resection in a child. Clin Orthop Relat Res 2009;467:572–577. https://doi.org/10.1007/s11999-008-0605-9
  • Ozaki T, Hillmann A, Bettin D, Wuisman P, Winkelmann W. Intramedullary, antibiotic-loaded cemented, massive allografts for skeletal reconstruction 26 cases compared with 19 uncemented allografts. Acta Orthop Scand 1997;68:387–391. https://doi.org/10.3109/17453679708996183
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Olgu Sunumu
Yazarlar

Yunus Demirtaş Bu kişi benim

Gökhan Çakmak Bu kişi benim

İsmail Öztürk Bu kişi benim

Ertuğrul Akşahin Bu kişi benim

Levent Çelebi Bu kişi benim

Yayımlanma Tarihi 25 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 1

Kaynak Göster

AMA Demirtaş Y, Çakmak G, Öztürk İ, Akşahin E, Çelebi L. Femur Diafizinde Ewing Sarkom ve Literatür İncelemesi. YIU Saglik Bil Derg. Nisan 2021;2(1):23-26. doi:10.51261/yiu.2021.00023