BCL-2 Protein Ailesi ve Kanser

Derya Babacan

doi:10.53433/yyufbed.1220984

TR EN

BCL-2 Protein Ailesi ve Kanser

Öz

Bu derlemenin odak noktası, BCL-2 ailesi proteinlerinin apoptozu düzenlemedeki rolüdür. Apoptoz, gelişimsel süreçte ve stres yanıtı olarak ortaya çıkan çok önemli bir biyolojik süreçtir. Bozulmuş apoptotik mekanizma kanser gelişiminde merkezi bir rol oynar ve ayrıca bilinen sitotoksik tedavilerin etkinliğini azaltır. B-hücreli lenfoma 2 (BCL-2) protein ailesinin üyeleri, pro- veya anti-apoptotik aktivitelere sahiptir ve son on yılda apoptozu, tümör oluşumunu ve antikanser tedavisine hücresel yanıtların düzenlemedeki önemleri açısından yoğun bir şekilde incelenmiştir. Apoptoz kaynaklı hücre ölümünün indüklediği inflamatuar yanıtlardan dolayı günümüzde apoptozu hedef alan antikanser ilaçların geliştirilmesi giderek daha fazla dikkat çekici hale gelmiştir. BCL-2 ailesi proteinlerinin apoptoz regülasyon mekanizması araştırılmış ve bütün bulgular, BCL-2 ailesi proteinlerinin kanser tedavisindeki potansiyelinin ne kadar önemli olduğunu vurgulamaktadır.

Anahtar Kelimeler

Apoptoz, BCL-2, Kanser, Programlanmış Hücre Ölümü

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Bitki Koruma (Diğer)

Bölüm

Derleme

Yazarlar

Derya Babacan ^*
0000-0001-6758-8556
Türkiye

Yayımlanma Tarihi

29 Aralık 2023

Gönderilme Tarihi

26 Aralık 2022

Kabul Tarihi

19 Nisan 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 28 Sayı: 3

DOI

https://doi.org/10.53433/yyufbed.1220984

IZ

https://izlik.org/JA76TJ76FN

APA

Babacan, D. (2023). BCL-2 Protein Ailesi ve Kanser. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 28(3), 1218-1232. https://doi.org/10.53433/yyufbed.1220984

AMA

1.Babacan D. BCL-2 Protein Ailesi ve Kanser. YYUFBED. 2023;28(3):1218-1232. doi:10.53433/yyufbed.1220984

Chicago

Babacan, Derya. 2023. “BCL-2 Protein Ailesi ve Kanser”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 28 (3): 1218-32. https://doi.org/10.53433/yyufbed.1220984.

EndNote

Babacan D (01 Aralık 2023) BCL-2 Protein Ailesi ve Kanser. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 28 3 1218–1232.

IEEE

[1]D. Babacan, “BCL-2 Protein Ailesi ve Kanser”, YYUFBED, c. 28, sy 3, ss. 1218–1232, Ara. 2023, doi: 10.53433/yyufbed.1220984.

ISNAD

Babacan, Derya. “BCL-2 Protein Ailesi ve Kanser”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 28/3 (01 Aralık 2023): 1218-1232. https://doi.org/10.53433/yyufbed.1220984.

JAMA

1.Babacan D. BCL-2 Protein Ailesi ve Kanser. YYUFBED. 2023;28:1218–1232.

MLA

Babacan, Derya. “BCL-2 Protein Ailesi ve Kanser”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 28, sy 3, Aralık 2023, ss. 1218-32, doi:10.53433/yyufbed.1220984.

Vancouver

1.Derya Babacan. BCL-2 Protein Ailesi ve Kanser. YYUFBED. 01 Aralık 2023;28(3):1218-32. doi:10.53433/yyufbed.1220984

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Clinical Medicine Insights: Oncology

https://doi.org/10.1177/11795549251360481

BCL-2 Protein Ailesi ve Kanser

BCL-2 Protein Ailesi ve Kanser

Öz

Anahtar Kelimeler

BCL-2 Protein Family and Cancer

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

NAT2 : A Novel Target in Intrahepatic Cholangiocarcinoma and its Role in Modulating Tumor Behavior