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The Anticancer Potential of Van Lake Basin Plants

Yıl 2024, , 787 - 797, 31.08.2024
https://doi.org/10.53433/yyufbed.1438150

Öz

For centuries, people have used plants for various needs, as well as for treating diseases. Due to the fact that synthetic drugs damage other organs of the body while treating diseases, the demand for herbal resources has been increasing in recent years. Cancer, a disease whose cases and death rates are quickly rising, is now and, the second leading cause of death just behind the cardiovascular diseases. The toxicity of modern chemotherapy and the resistance of cancer cells to anticancer agents have led the scientific world to search for new treatments and prevention methods for this insidious disease. The therapeutic properties of plants, which generally do not have significant side effects, are associated with biologically active organic compounds, and the geochemical composition of the region where they grow. Van Lake Basin has a rich plant diversity thanks to its climate, geographical features, and soil content. This region is home to many medicinal plant species used by humans but have not yet been studied, and their phytochemical structures are still not fully elucidated. Although humans have used these plants for centuries, as inherited from ancestors, studies are required to prove their therapeutic effects in vivo and in vitro. This study presents the anticancer potentials of some crucial plants (Eryngium billardieri, Cichorium intybus, Bongardia chrysogonum, Bryonia multiflora, Euphorbia macroclada, Scutellaria orientalis, Plantago major, Primula auriculata) reported to be used in treating various diseases in the Van Lake Basin by analyzing the in vitro and in vivo anticancer studies conducted with the same plants in the literature.

Kaynakça

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Van Gölü Havzası Bitkilerinin Antikanser Potansiyeli

Yıl 2024, , 787 - 797, 31.08.2024
https://doi.org/10.53433/yyufbed.1438150

Öz

İnsanlar yüzyıllar boyunca bitkileri çeşitli ihtiyaçlarının yanı sıra hastalıkların tedavisinde de kullanmışlardır. Sentetik ilaçların hastalıkları tedavi ederken vücudun diğer organlarına zarar vermesi nedeniyle son yıllarda bitkisel kaynaklara olan talep giderek artmaktadır. Görülme sıklığı ve ölüm oranı hızla artan bir hastalık olan kanser, günümüzde kalp ve damar hastalıklarından sonra ikinci sırada yer almaktadır. Modern kemoterapinin toksisitesi ve kanser hücrelerinin antikanser ajanlara karşı direnç göstermesi, bilim dünyasını bu sinsi hastalık için yeni tedavi ve korunma yöntemleri aramaya yöneltmiştir. Genellikle önemli yan etkileri olmayan bitkilerin tedavi edici özellikleri, biyolojik olarak aktif organik bileşikler ve yetiştikleri bölgenin jeokimyasal bileşimi ile ilişkilidir. Van Gölü Havzası, iklimi, coğrafi özellikleri ve toprak içeriği sayesinde zengin bir bitki çeşitliliğine sahiptir. Bu bölge, insanlar tarafından kullanılan ancak henüz araştırılmamış birçok tıbbi bitki türüne ev sahipliği yapmaktadır ve fitokimyasal yapılarının hala tam olarak anlaşılması gerekmektedir. Her ne kadar insanlar, atalarından gördükleri gibi bu bitkileri yüzyıllardır kullanmış olsalar da, in vivo ve in vitro terapötik etkilerini kanıtlamak için çalışmalara ihtiyaç vardır. Bu çalışma, Van Gölü Havzası'nda çeşitli hastalıkların tedavisinde kullanıldığı bildirilen bazı önemli bitkilerin (Eryngium billardieri, Cichorium intybus, Bongardia chrysogonum, Bryonia multiflora, Euphorbia macroclada, Scutellaria orientalis, Plantago major, Primula auriculata) antikanser potansiyellerini, literatürde aynı bitkilerle yapılan in vitro ve in vivo antikanser çalışmalarını analiz ederek sunmaktadır.

Etik Beyan

Yayında etik beyan gerektirecek herhangi bir çalışma veya veri bulunmamaktadır.

Kaynakça

  • Abuhamdah, S., Shatarat, A., Al-Essa, M., Al-Ameer, H., Al-Olimat, S., & Chazot, P. (2017). Spasmolytic and antimicrobial activities of crude extract of Bongardia chrysogonum L. tubers. International Journal of Pharmacology, 14(1), 52-60. https://doi.org/10.3923/ijp.2018.52.60
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  • Alkan, E. E., Çelik, İ., & Bati, B. (2023). Antidiabetic and antioxidant effects of Bryonia multiflora Boiss. & Heldr. in a rat model of streptozotocin-induced diabetes. Experimental and Applied Medical Science, 4(1), 442-459. https://doi.org/10.46871/eams.1287621
  • Altundag, E., & Ozturk, M. (2011). Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia-Social and Behavioral Sciences, 19, 756-777. https://doi.org/10.1016/j.sbspro.2011.05.195
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  • Ashraf, K., Halim, H., Lim, S. M., Ramasamy, K., & Sultan, S. (2020). In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of orthosiphon stamineus, gynura procumbens and ficus deltoidea. Saudi Journal of Biological Sciences, 27(1), 417-432. https://doi.org/10.1016/j.sjbs.2019.11.003
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  • Gezici, S., & Şekeroğlu, N. (2021). Bongardia chrysogonum (L.) Spach as a potential medicinal plant against cancer and Alzheimer’s disease management. İstanbul Journal of Pharmacy, 51(3), 319-325. http://dx.doi.org/10.26650/IstanbulJPharm.2021.892746
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  • Hetland, G., Samuelsen, A. B., Løvik, M., Paulsen, B. S., Aaberge, I. S., Groeng, E. C., & Michaelsen, T. E. (2000). Protective effect of Plantago major L Pectin polysaccharide against systemic Streptococcus pneumoniae infection in mice. Scandinavian Journal Immunology, 52(4), 348-355. https://doi.org/10.1046/j.1365-3083.2000.00793.x
  • Holetz, F. B., Pessini, G. L., Sanches, N. R., Cortez, D. A. G., Nakamura, C. V., & Dias Filho, B. P. (2002). Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Memórias do Instituto Oswaldo Cruz, 97(7), 1027-1031. https://doi.org/10.1590/S0074-02762002000700017
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  • Jamilah, J., Sharifa, A. A., & Sharifah, N. R. S. A. (2012). GC-MS analysis of various extracts from leaf of Plantago major used as traditional medicine. World Applied Sciences Journal, 17, 67-70.
  • Kaya, A. (2010, June). Tıbbi bitkiler ve etnobotanik çalışmalar. Bitkilerle Tedavi Sempozyumu, 11-18, Zeytinburnu/İstanbul.
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  • Khan, M. F., Nasr, F. A., Noman, O. M., Alyhya, N. A., Ali, I., Saoud, M., … & Hussain, H. (2020). Cichorins D-F: Three new compounds from Cichorium intybus and their biological effects. Molecules, 25(18), 4160. https://doi.org/10.3390/molecules25184160
  • Kikowska, M., Chanaj-Kaczmarek, J., Derda, M., Budzianowska, A., Thiem, B., Ekiert, H., & Szopa, A. (2022). The evaluation of phenolic acids and flavonoids content and antiprotozoal activity of Eryngium species biomass produced by biotechnological methods. Molecules, 27(2), 363. https://doi.org/10.3390/molecules27020363
  • Kuo, H. M., Tsai, H. C., Lin, Y. L., Yang, J. S., Huang, A. C., Yang, M. D., … & Chung, J. G. (2009). Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells. International Journal of Oncology, 35(4), 717-724. https://doi.org/10.3892/ijo_00000384
  • Lohani, M., Ahuja, M., Buabeid, M. A., Schwartz, D., Shannon, D., Suppiramaniam, V., … & Dhanasekaran, M. (2013). Anti-oxidative and DNA protecting effects of flavonoids-rich Scutellaria lateriflora. Natural Product Communications, 8(10), 1415-1418. https://doi.org/10.1177/1934578X1300801019
  • Marsh, Z., Yang, T., Nopo-Olazabal, L., Wu, S., Ingle, T., Joshee, N., & Medina-Bolivar, F. (2014). Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. Phytochemistry, 107, 50-60. https://doi.org/10.1016/j.phytochem.2014.08.020
  • Mehrandish, R., Awsat-Mellati, A., Rahimipour, A., & Dehghan-Nayeri, N. (2017). Anti-cancer activity of methanol extracts of Cichorium intybus on human breast cancer SKBR3 cell line. Razavi International Journal of Medicine, 5(1), e38369.
  • Miro, M. (1995). Cucurbitacins and their pharmacological effects. Phytotherapy Research, 9(3), 159-168. https://doi.org/10.1002/ptr.2650090302
  • Mohammadi, A., Mansoori, B., Aghapour, M., & Baradaran, B. (2016). Urtica dioica dichloromethane extract induce apoptosis from intrinsic pathway on human prostate cancer cells (pc3). Cellular and Molecular Biology, 62(3), 78-83.
  • Mükemre, M., Behçet, L., & Çakılcıoğlu, U. (2016). Survey of wild food plants for human consumption in villages of Çatak (Van-Turkey). Indian Journal of Traditional Knowledge IJTK, 15(2), 183-191.
  • Nawab, A., Yunus, M., Mahdi, A.A., & Gupta, S. (2011). Evaluation of anti-cancer properties of medicinal plants from the Indiansub-continent. Molecular and Cellular Pharmacology, 3(1), 21-29.
  • Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006). A review of the effects and mechanisms of polyphenolics in cancer. Critical Reviews in Food Science and Nutrition, 46(2), 161-183. https://doi.org/10.1080/10408390591000541
  • Oran, S. A., Yousef, I., & Jaffal, S. M. (2022). Evaluation of the antiproliferative effect of selected plant extracts on colon and skin cancer cell lines. Journal of Applied Pharmaceutical Science, 12(11), 091-096. https://dx.doi.org/10.7324/JAPS.2022.121110
  • Ozaslan, M., Didem Karagöz, I., Kalender, M.E., Kilic, I. H., Sari, I., Karagöz, A. (2007). In vivo antitumoral effect of Plantago major L extract on BALB/C mouse with Ehrlich ascites tumor. American Journal of Chinese Medicine, 35(5), 841-851. https://doi.org/10.1142/S0192415X07005314
  • Özgökçe, F., & Özçelik, H. (2004). Ethnobotanical aspects of some taxa in East Anatolia, Turkey. Economic Botany, 58(4), 697-704. https://doi.org/10.1663/0013-0001(2004)058[0697:EAOSTI]2.0.CO;2
  • Parajuli, P., Joshee, N., Chinni, S. R., Rimando, A. M., Mittal, S., Sethi, S., & Yadav, A. K. (2011). Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. Journal of Neuro-Oncology, 101, 15-24. https://doi.org/10.1007/s11060-010-0221-x
  • Paşayeva, L., Köngül, E., Geylan, R., Karatoprak, G. Ş., & Tugay, O. (2017). Analysis of the cytotoxic effects of Eryngium billardieri Delar. Extracts on MCF7 cell line. Proceedings, 1, 1055. https://doi.org/10.3390/proceedings1101055
  • Rahamooz-Haghighi, S., Bagheri, K., Danafar, H., & Sharafi, A. (2021). Anti-proliferative properties, biocompatibility, and chemical composition of different extracts of plantago major medicinal plant. Iranian Biomedical Journal, 25(2), 106-116. http://dx.doi.org/10.29252/ibj.25.2.106
  • Ramsay, J. R., Suhrbier, A., Aylward, J. H., Ogbourne, S., Cozzi, S. J., Poulsen, M. G., … & Parsons, P. G. (2011). The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers. British Journal of Dermatology, 164(3), 633-636. https://doi.org/10.1111/j.1365-2133.2010.10184.x
  • Roshanravan, N., Asgharian, P., Dariushnejad, H., Alamdari, N. M., Mansoori, B., Mohammadi, A., … & Ostadrahimi, A. (2018). Eryngium Billardieri induces apoptosis via Bax gene expression in pancreatic cancer cells. Advanced Pharmaceutical Bulletin, 8(4), 667-74. https://doi.org/10.15171/apb.2018.075
  • Saleem, M., Abbas, K., Naseer, F., Ahmad, M., Syed, N. H., Javed, F., … & Asima, S. (2014). Anticancer activity of n-hexane extract of Cichorium intybus on lymphoblastic leukemia cells (Jurkat cells). African Journal of Plant Science, 8(6), 315-319. https://doi.org/10.5897/AJPS2013.1021
  • Samuelsen, A. B. (2000). The traditional uses, chemical constituents and biological activities of Plantago major L. A review. Journal of Ethnopharmacology, 71(1-2), 1-21. https://doi.org/10.1016/S0378-8741(00)00212-9
  • Seca, A. M. L., & Pinto, D. C. (2018). Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application. International Journal of Molecular Sciences, 19(1), 263. https://doi.org/10.3390/ijms19010263
  • Sezik, E., Yesilada, E., Honda, G., Takaishi, Y., Takeda, Y., & Tanaka, T. (2001). Traditional medicine in Turkey X. Folk medicine in Central Anatolia. Journal of Ethnopharmacology, 75(2-3), 95-115. https://doi.org/10.1016/S0378-8741(00)00399-8
  • Sharma, D., Purohit, N., Chaubey, S., Tiwari, M., Bhadauriya, M., Mohit, Bhasker, N., & Kumar, D. (2022). A review on pharmacological and therapeutic potential of aloe barbadensis miller. European Journal of Medicinal Plants, 33(6), 23-43. https://doi.org/10.9734/ejmp/2022/v33i630471
  • Soltani, G. M., Hemati, S., Sarvizadeh, M., Kamalinejad, M., Tafazoli, V., & Latifi, S. A. (2020). Efficacy of the plantago major L. syrup on radiation induced oral mucositis in head and neck cancer patients: A randomized, double blind, placebo-controlled clinical trial. Complementary Therapies in Medicine, 51, 102397. https://doi.org/10.1016/j.ctim.2020.102397
  • Song, J., Ahn, C., Chun, C. H., & Jin, E. J. (2014). A long non‐coding RNA, GAS5, plays a critical role in the regulation of miR‐21 during osteoarthritis. Journal of Orthopaedic Research, 32(12), 1628-1635. https://doi.org/10.1002/jor.22718
  • Tabata, M., Sezik, E., Honda, G., Yeşilada, E., Fukui, H., Goto, K., & Ikeshiro, Y. (1994). Traditional medicine in Turkey III. Folk medicine in East Anatolia, Van and Bitlis provinces. International Journal of Pharmacognosy, 32(1), 3-12. https://doi.org/10.3109/13880209409082966
  • Tan, H. Y., Wang, N., Man, K., Tsao, S. W., Che, C. M., & Feng, Y. (2015). Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin. Cell Death & Disease, 6(10), e1942-e1942. https://doi.org/10.1038/cddis.2015.271
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  • Vauzour, D., Rodriguez-Mateos, A., Corona, G., Oruna-Concha, M. J., & Spencer, J. P. E. (2010). Polyphenols and human health: Prevention of disease and mechanisms of action. Nutrients, 2(11), 1106-1131. https://doi.org/10.3390/nu2111106
  • Wang, L., Chen, W., Li, M., Zhang, F., Chen, K., & Chen, W. (2020). A review of the ethnopharmacology, phytochemistry, pharmacology, and quality control of Scutellaria barbata D. Don. Journal of Ethnopharmacology, 254, 112260. https://doi.org/10.1016/j.jep.2019.112260
  • Yaşar, M., Oguzkan, S. B., & Ugras, H. I. (2021). Some bioactive component analysis of herbal capsules. GSC Biological and Pharmaceutical Sciences, 17(2), 057-062. https://doi.org/10.30574/gscbps.2021.17.2.0271
  • Yeşilada, E., Tanaka, S., Tabata, M., & Sezik, E. (1989). The antiinflammatory activity of the fractions from Eryngium billardieri in mice. Phytotherapy Research, 3(1), 38-40. https://doi.org/10.1002/ptr.2650030111
  • Yu, B., Zheng, Y. C., Shi, X. J., Qi, P. P., & Liu, H. M. (2016). Natural product-derived spirooxindole fragments serve as privileged substructures for discovery of new anticancer agents. Anti-Cancer Agents in Medicinal Chemistry, 16(10), 1315-1324. http://dx.doi.org/10.2174/1871520615666151102093825
  • Zhang, J., Wang, P., Wan, L., Xu, S., & Pang, D. (2017a). The emergence of noncoding RNAs as Heracles in autophagy. Autophagy, 13(6), 1004-1024. https://doi.org/10.1080/15548627.2017.1312041
  • Zhang, X., Du, L., Zhang, W., Yang, Y., Zhou, Q., & Du, G. (2017b). Therapeutic effects of baicalein on rotenone-induced Parkinson’s disease through protecting mitochondrial function and biogenesis. Scientific Reports, 7(1), 9968. https://doi.org/10.1038/s41598-017-07442-y
  • Zhou, C. X., Zou, L., Zhao, Z. Z., Zhu, H., He, Q. J., Yang, B., & Gan, L. S. (2012). Terpenoids from Cichorium intybus. Natural Product Communication, 7(8), 971-972. https://doi.org/10.1177/1934578X1200700801
Toplam 73 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Hücresi ve Moleküler Biyoloji, Bitki Bilimi (Diğer)
Bölüm Derleme Makaleler / Review Articles
Yazarlar

Gül Görmez 0000-0001-6980-4988

Yayımlanma Tarihi 31 Ağustos 2024
Gönderilme Tarihi 16 Şubat 2024
Kabul Tarihi 29 Mayıs 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Görmez, G. (2024). The Anticancer Potential of Van Lake Basin Plants. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 29(2), 787-797. https://doi.org/10.53433/yyufbed.1438150