Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller

Büşra Şensoy Gün; Mustafa Çiftçi

doi:10.53433/yyufbed.1702653

EN TR

Metal/Metal Oxide Nanoparticles Produced by Green Synthesis Targeting the Blood-Brain Barrier

Öz

The blood-brain barrier (BBB) is a significant obstacle in the treatment of neurological diseases due to its selectively permeable structure, which protects the central nervous system (CNS) from harmful substances. In recent years, nanotechnological carrier systems developed to overcome this barrier have attracted great interest. Metal and metal oxide nanoparticles (ZnO, FeO, Ag, Au), produced under environmentally friendly conditions with green synthesis methods, stand out due to their suitable size, surface charge, and biocompatibility properties to cross the BBB. These biogenic nanostructures synthesized using plant extracts, microorganisms, or biomolecules offer low toxicity, long circulation time, and targeted transport potential, making them promising candidates for the treatment of neurodegenerative diseases. In this review, studies on the production of green synthesized metal and metal oxide nanoparticles and their brain-targeted applications are examined. The findings indicatethat these nanostructures may provide safe and effective alternatives for brain-targeted drug delivery and diagnostic systems.

Anahtar Kelimeler

Blood brain barrier, Green synthesis, Metal/metal oxide nanoparticle, Nanostructures

Etik Beyan

Bu makalenin yazarları çalışmalarında araştırma ve yayın etiğine uyduklarını beyan ederler. Bu makalenin yazarları çalışmada kullanılan materyal ve yöntemlerin etik kurul izni ve/veya yasal-özel bir izin gerektirmediğini beyan ederler.

Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller

Öz

Kan-beyin bariyeri (KBB), merkezi sinir sistemini (MSS) zararlı maddelerden koruyan seçici geçirgen yapısıyla, nörolojik hastalıkların tedavisinde önemli bir engel oluşturmaktadır. Son yıllarda, bu bariyeri aşmak amacıyla geliştirilen nanoteknolojik taşıyıcı sistemler büyük ilgi görmektedir. Özellikle yeşil sentez yöntemleriyle çevre dostu koşullarda üretilen metal ve metal oksit nanopartiküller (ZnO, FeO, Ag, Au), KBB’yi geçmeye uygun boyut, yüzey yükü ve biyouyumluluk özellikleriyle öne çıkmaktadır. Bitkisel özütler, mikroorganizmalar veya biyomoleküller aracılığıyla sentezlenen bu biyojenik nanoyapılar; düşük toksisite, uzun dolaşım süresi ve hedefe yönelik taşıma potansiyeli sunarak, nörodejeneratif hastalıkların tedavisinde umut vadetmektedir. Bu derlemede, yeşil sentezli metal ve metal oksit nanopartiküllerin üretimi ve beyne hedefli kullanım alanını kapsayan araştırmalar incelenmiştir. Elde edilen bulgular, bu nanoyapıların beyin hedefli ilaç taşıma ve tanı sistemlerinde güvenli ve etkili alternatifler sunabileceğini göstermektedir.

Anahtar Kelimeler

Kan beyin bariyeri, Metal/metal oksit nanopartikül, Nanoyapılar, Yeşil sentez

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Nanobiyoteknoloji, Nanomalzemeler

Bölüm

Derleme

Yazarlar

Büşra Şensoy Gün ^*
0000-0001-5190-9490
Türkiye

Mustafa Çiftçi
0009-0001-8123-8613
Türkiye

Yayımlanma Tarihi

24 Aralık 2025

Gönderilme Tarihi

20 Mayıs 2025

Kabul Tarihi

8 Eylül 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 30 Sayı: 3

DOI

https://doi.org/10.53433/yyufbed.1702653

IZ

https://izlik.org/JA66UF69CZ

APA

Şensoy Gün, B., & Çiftçi, M. (2025). Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 30(3), 1188-1202. https://doi.org/10.53433/yyufbed.1702653

AMA

1.Şensoy Gün B, Çiftçi M. Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller. YYUFBED. 2025;30(3):1188-1202. doi:10.53433/yyufbed.1702653

Chicago

Şensoy Gün, Büşra, ve Mustafa Çiftçi. 2025. “Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 30 (3): 1188-1202. https://doi.org/10.53433/yyufbed.1702653.

EndNote

Şensoy Gün B, Çiftçi M (01 Aralık 2025) Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 30 3 1188–1202.

IEEE

[1]B. Şensoy Gün ve M. Çiftçi, “Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller”, YYUFBED, c. 30, sy 3, ss. 1188–1202, Ara. 2025, doi: 10.53433/yyufbed.1702653.

ISNAD

Şensoy Gün, Büşra - Çiftçi, Mustafa. “Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 30/3 (01 Aralık 2025): 1188-1202. https://doi.org/10.53433/yyufbed.1702653.

JAMA

1.Şensoy Gün B, Çiftçi M. Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller. YYUFBED. 2025;30:1188–1202.

MLA

Şensoy Gün, Büşra, ve Mustafa Çiftçi. “Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 30, sy 3, Aralık 2025, ss. 1188-02, doi:10.53433/yyufbed.1702653.

Vancouver

1.Büşra Şensoy Gün, Mustafa Çiftçi. Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller. YYUFBED. 01 Aralık 2025;30(3):1188-202. doi:10.53433/yyufbed.1702653

Metal/Metal Oxide Nanoparticles Produced by Green Synthesis Targeting the Blood-Brain Barrier

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Kan Beyin Bariyeri Hedefli Yeşil Sentezle Üretilen Metal/Metal Oksit Nanopartiküller

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