In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl

Şebnem Şenol

doi:10.53433/yyufbed.1792754

TR EN

In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl

Öz

This study aims to prepare sodium alginate/gelatin-based delivery systems for paracetamol (C₈H₉NO₂) and metformin HCl (C₄H₁₁N₅·HCl). Twelve sodium alginate/gelatin-based hydrogel films were synthesized using the casting method with the addition of hydroxyapatite, starch, and clinoptilolite. The drug release properties of the hydrogels were investigated in a pH 7.4 medium. Based on drug release performance, model hydrogels containing paracetamol and metformin HCl were selected. The selected hydrogels were characterized using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM). It was determined that the selected hydrogels are suitable delivery systems for the active pharmaceutical ingredients.

Anahtar Kelimeler

Polymeric Hydrogels, Paracetamol, Metformin HCl, Drug delivery

Destekleyen Kurum

The author received no financial support for the research, authorship, and/or publication of this article.

Etik Beyan

The author declares that all procedures followed were in accordance with research and publication ethics. The author declares that the material and methods used do not require ethics committee approval and/or any legal or special permission.

Teşekkür

Yazar, Prof. Dr. Emel Akyol ve Merve Gülter Ak’a nazik destekleri için çok teşekkür eder.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Polimer Bilimi ve Teknolojileri

Bölüm

Araştırma Makalesi

Yazarlar

Şebnem Şenol ^*
0000-0002-6420-995X
Türkiye

Yayımlanma Tarihi

29 Nisan 2026

Gönderilme Tarihi

28 Eylül 2025

Kabul Tarihi

2 Mart 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 31

DOI

https://doi.org/10.53433/yyufbed.1792754

IZ

https://izlik.org/JA93JP66XG

APA

Şenol, Ş. (2026). In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 31, 95-107. https://doi.org/10.53433/yyufbed.1792754

AMA

1.Şenol Ş. In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl. YYUFBED. 2026;31:95-107. doi:10.53433/yyufbed.1792754

Chicago

Şenol, Şebnem. 2026. “In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 31 (Nisan): 95-107. https://doi.org/10.53433/yyufbed.1792754.

EndNote

Şenol Ş (01 Nisan 2026) In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 31 95–107.

IEEE

[1]Ş. Şenol, “In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl”, YYUFBED, c. 31, ss. 95–107, Nis. 2026, doi: 10.53433/yyufbed.1792754.

ISNAD

Şenol, Şebnem. “In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 31 (01 Nisan 2026): 95-107. https://doi.org/10.53433/yyufbed.1792754.

JAMA

1.Şenol Ş. In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl. YYUFBED. 2026;31:95–107.

MLA

Şenol, Şebnem. “In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 31, Nisan 2026, ss. 95-107, doi:10.53433/yyufbed.1792754.

Vancouver

1.Şebnem Şenol. In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl. YYUFBED. 01 Nisan 2026;31:95-107. doi:10.53433/yyufbed.1792754

In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl

Parasetamol’un ve Metformin HCl'nin Transdermal İlaç Salımı İçin Film Hidrojellerin In Vitro Değerlendirilmesi

Öz

Anahtar Kelimeler

In Vitro Evaluation of Film Hydrogels for Transdermal Drug Delivery of Paracetamol and Metformin HCl

Öz

Anahtar Kelimeler

Destekleyen Kurum

Etik Beyan

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster