Bifidojenik Faktör Olarak Laktoz Türevlerinin Önemi

Yıl 2016, Cilt: 30 Sayı: 2, 79 - 90, 05.12.2016

Lütfiye Yılmaz-ersan , Tülay Özcan Arzu Akpınar-bayizit Berrak Delikanlı

Öz

Laktoz sadece memeli hayvanların sütlerinde bulunan bir disakkarittir. Oldukça düşük tatlandırma gücü, kalori değeri ve glisemik indeksi nedeniyle dikkat çekici besleyici bir özelliğe sahiptir. Aynı zamanda, diyet lif benzeri prebiyotik özelliğe sahip olup kalsiyum ve magnezyumun biyoyararlılığını arttırmaktadır. Laktoz türevleri olan laktuloz, laktitol, laktobionik asit ve tagatoz gıdalarda ve farmasötik karışımlarda bağırsak sağlığını iyileştirici prebiyotik olarak yer almaktadır. Bifidobacterium türleri probiyotik mikroorganizma olarak sağlık üzerine olumlu etkileri nedeniyle farklı gıda ürünlerinde geniş ölçüde kullanılmaktadırlar. Bu derlemenin amacı, ticari olarak üretilen laktoz türevlerinin bifidojenik faktör olarak Bifidobacterium türlerinin gelişmelerini destekleme yeteneklerini özetlemektir.

Anahtar Kelimeler

Laktoz türevleri, probiyotik, prebiyotik

Kaynakça

• Akalın S. 2002. Laktuloz üretimi, gıda ve farmakoloji endüstrisinde kullanımı. Gıda, 27: 475-478.
• Alonso S., Rendueles M. and M. Diaz. 2011. Efficient lactobionic acid production from whey by Pseudomonas taetrolens under pH-shift conditions. Bioresource Technology, 102: 9730-9736.
• Biavati B. and P. Mattarelli. 2001. The family Bifidobacteriaceae. In: The prokaryotes. (M Dworkin, S Falkow, E Rosenberg, KH. Schleifer, E Stackebrandt, editors). New York, Springer-Verlag.
• Bruzzese E., Volpicelli M., Squaglia M., Tartaglione A. and A. Guarino. 2006. Impact of prebiotics on human health. Digestive and Liver Disease, 38: 283-287.
• Castro M., Calvo M.M. and A. Olano. 1987. Chromatographic determination of lactulose. Chromotographia, 23: 132-136.
• Chouraqui J.P., Grathwohl D., Labaune J.M., Hascoet J.M., de Montgolger I., Leclaire M., Giarre M. and P. Steenhout. 2008. Assessment of the safety, tolerance and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. American Journal of Clinical Nutrition, 87: 1365-1373.
• De Vuyst L., Falony G. and F. Leroy. 2008. Probiotics in fermented sausages. Meat Science, 80: 75-78.
• Espinoza Y.R. and Y.G. Navarro. 2010. Non-dairy probiotic products. Food Microbiology, 27: 1-11.
• Ewaschuk J.B. and L.A. Dieleman. 2006. Probiotics and prebiotic sinchronic inflammatory bowel disease. World Journal of Gastroenterology, 12: 5941-5950.
• Fischer E. and J. Meyer. 1889. Oxydation des milchzuckers. Deutsche Chemische Gesellschaft, 22: 361-364.
• Ganzle M.G. 2012. Enzymatic synthesis of galactooligosaccharides and other lactose derivatives (heterooligosaccharides) from lactose. International Dairy Journal, 22: 116-122.
• Ganzle M.G., Haase G. and P. Jelen. 2008. Lactose: crystallization, hydrolysis and value-added derivatives. International Dairy Journal, 18: 685-694.
• Gibson G.R., Probert H.M., Van Loo J., Rastall R.A. and M.B. Roberfroid. 2004. Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics. Nutrition Research Reviews, 17: 259-275.
• Gibson G.R. and M. Roberfroid. 2008. Handbook of prebiotics. (FL Boca Raton, editor). CRC Press. 504 p.
• Goderska K., Nowak J. and Z. Czarnecki. 2008. Comparison of the growth of Lactobacillus acidophilus and Bifidobacterium bifidum species in media supplemented with selected saccharides including prebiotics. ACTA Scientiarum Polonorum, 7: 5-20.
• Gutierrez L.F., Hamoudi S. and K. Belkacemi. 2011. Selective production of lactobionic acid by aerobic oxidation of lactose over gold crystallites supported on mesoporous silica. Applied Catalysis A: General, 402: 94-103.
• Halttnen H., Rajakyla E., Nurmi J., Perkkalaınen P. and I. Pitkanen. 2001. Comparison of two melting range analysis methods with lactitol monohydrate. Thermochimica Acta, 38: 55-65.
• Harju M. 2000. Milk sugar and minerals as ingredients. International Journal of Dairy Technology, 54: 61-63.
• Ishwarya S.P. and P. Prabhasankar. 2014. Prebiotics: Application in bakery and pasta products. Critical Reviews in Food Science and Nutrition, 54: 511-522.
• Isolauri E. 2004. The role of probiotics in pediatrics. Current Pediatric reviews, 14: 104-109.
• Kaptan H. 2000. Bifidobacterialar. Gıda, 25: 459-465.
• Kaur I.P., Chopra K. and A. Saini. 2002. Probiotics: Potential pharmaceutical applications. European Journal of Pharmaceutical Sciences, 15: 1-9.
• Kneifel W., Rajal A. and K.D. Kulbe. 2000. In vitro growth behaviour of probiotic bacteria in culture media with carbohydrates of prebiotic importance. Microbial Ecology in Health and Disease, 12: 27-34.
• Kontula P., Suihko M.L., Wright A.V. and T. Mattila-Sandholm. 1999. The effect of lactose derivatives on intestinal lactic acid bacteria. Journal of Dairy Science, 82: 249-256.
• Krasaekoopt W., Bhandari B. and H. Deeth. 2006. Survival of probiotics encapsulated in chitosan-coated alginate beads in yoghurt from UHT- and conventionally treated milk during storage. LWT-Food Science Technology, 39: 177-183.
• Leahy S.C., Higgins D.G., Fitzgerald G.F. and Va D. Sinderen. 2005. Getting better with Bifidobacteria. Journal of Applied Microbiology, 98: 1303-1315.
• Levin G.V. 2002. Tagatose, the new GRAS sweetener and health product. Journal of Medicine and Food, 5: 23-36.
• Makelainen H., Saarinan M., Stowell J., Rautonen N. and A.C. Ouwehand. 2010. Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures. Beneficial Microbes, 1: 139-148.
• McKinley M.C. 2005. The nutrition and health benefits of yoghurt. International Journal of Dairy Technology, 58: 1-12.
• Mussatto S.I. and I.M. Mancilha. 2007. Non-digestible oligosaccarides. Carbohydrate Polymers, 68: 587-597.
• Nakano H., Kiryu T., Kiso T. and H. Murakami. 2010. Biocatalytic production of lactobionic acid. In: Biocatalysis and biomolecular engineering. (CT Hou, JF Shaw, editors). USA: John Wiley & Sons, Inc. 391-404 p.
• Nordkvist M., Nielsen P.M. and J. Villadsen. 2007. Oxidation of lactose to lactobionic acid by a Microdochium nivale carbohydrate oxidase: kinetics and operational stability. Biotechnology and Bioengineering, 97: 694-707.
• Olaiz-Fernandez G., Rivera-Dommarco J., Shamah-Levy T., Rojas R., Villalpando-Hernandez S. and M. Hernandez-Avila. 2006. National health and nutrition survey. National Institute of public health, 131.
• Oliveira A., Florence P., Perego M. and A. Oliveira. 2011a. Use of lactulose as prebiotic and its influence on the growth, acidification profile and viable counts of different probiotics in fermented skim milk. International Journal of Food Microbiology, 145: 22-27.
• Oliveira R., Perego P., Oliveira M. and A. Converti. 2011b. Effect of inulin as a prebiotic to improve growth and counts of a probiotic cocktail in fermented skim milk. LWT-Food Science and Technology, 44: 520-523.
• Ouwehand A.C., Salminen S. and E. Isolauri. 2002. Probiotics: An overview of beneficial effects. Antonie van Leeuwenhoek, 82: 279-289.
• Özden A. 2005. Laktuloz-Prebiyotik. Güncel Gastroenteroloji, 4: 209-222.
• Parracho H., McCartney A.L. and G.R. Gibson. 2007. Probiotics and prebiotics in infant nutrition. Proceedings of Nutrition Society, 66: 405-411.
• Pedreschi R., Campos D., Noratto G., Chirinos R. and L. Cisneros-Zevallos. 2003. Andean yacon root (Smallanthus sonchifolius Poepp. Endl) fructooligosaccharides as a potential novel source of prebiotics. Journal of Agricultural and Food Chemistry, 51: 5278-5284.
• Petuely F. 1957. Der bifidusfaktor. Deutsche Medizinische Wochenschrift, 82: 1957-1960.
• Playne M.J. and R.G. Crittenden. 2009. Galacto-oligosaccharides and other products derived from lactose. In: Lactose, water, salts and minor constituents (PLH McSweeney, PF Fox, editors). New York, NY, USA: Springer. 121-201 p.
• Pompei A., Cordisco L., Raimondi S., Amaretti A., Pagnoni U.M., Matteuzzi D. and M. Rossi. 2008. In vitro comparison of the prebiotic effects of two ınulin-type fructans. Anaerobe, 14: 280-286.
• Puccio G., Cajozzo C., Meli F., Rochat F., Grathwohl D. and P. Steenhout. 2007. Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition, 23: 1-8.
• Puneeth-Kumar C.L., Sushma-Saroja Y., Mukesh-Kumar D.J. and P.T. Kalaichelvan. 2012. Bifidobacteria for life betterment. World Applied Sciences Journal, 17: 1454-1465.
• Roberfroid. M. B. 2007. Prebiotics: The concept revisited. Journal of Nutrition, 137: 830-837.
• Röble C.H., Auty M., Brunton N., Gormley R. and F. Butler. 2010. Alginate coating as carrier of oligofructose and inulin and to maintain the quality of fresh-cut apples. Innovative Food Science Emerging Technology, 11: 203-209.
• Rycroft C.E., Jones M.R., Gibson G.R. and R.A. Rastall. 2008. A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. Journal of Applied Microbiology, 91: 878-887.
• Saad N., Delattre C., Urdaci M., Schmitter J.M. and P. Bressollier. 2013. An overview of the last advances in probiotic and prebiotic field. LWT-Food Science Technology, 50: 1-16.
• Saarela M., Hallmaa K., Mattila-Sandholm T. and J. Mattö. 2003. The effect of lactose derivates lactulose, lactitol and lactobionic acid on the functional and technological properties of potentially probiotic Lactobacillus strains. International Dairy Journal, 13: 291-302.
• Salminen S., Ouwehand A.C. and E. Isolauri. 2002. Probiotics: An overview of beneficial effects. Antonie van Leeuwenhoek, 82: 279.
• Samona A., Robinson R.K. and S. Marakis. 1996. Acid production by Bifidobacteria and yoghurt bacteria during fermentation and storage of milk. Food Microbiology, 13: 275-280.
• Sarkar S. 2007. Potential of prebiotics as functional foods. Nutrition and Food Science, 373: 168-177.
• Schaafsma G. 2008. Lactose and lactose derivates as bioactive ingredients in human nutrition. International Dairy Journal, 18: 458-465.
• Seki N. and H. Saito. 2012. Lactose as a source for lactulose and other functional lactose derivatives. International Dairy Journal, 22: 110-115.
• Shah N.P. 2001. Functional foods from probiotics and prebiotics. Food Technology, 55: 46-53.
• Shah N.P. 2006. Probiotics and fermented milk. In: Manufacturing yogurt and fermented milk. (RC, Chandan, editor). Oxford, U.K.: Blackwell Publishing Ltd. 341-354 p.
• Shin H.S., Lee H., Pestka, J.J. and Z. Ustunol. 2000. Growth and viability of commercial Bifidobacterium spp. in skim milk containing oligosaccharides and inulin. Journal of Food Science, 65: 884-887.
• Soomro A.H., Masud J. and K. Anwaar. 2002. Role of lactic acid bacteria (LAB) in food preservation and human health. Pakistan Nutrition, 1: 20.
• Sungsoo C.H. and E.T. Finocchiaro. 2010. Handbook of prebiotics and probiotics Ingredients. In: Health benefits and food aplications. (FL Boca-Raton, editor). CRC Pres 435 p.
• Tabatabaie F. and A. Mortazavi. 2008. Influence of lactulose on the survival of probiotic strains in yoghurt. World Applied Sciences Journal, 3: 88-90.
• Tamura V., Mizota T., Shihamura S. and Y. Tomitam. 1993. Lactulose and ıts application to the food and pharmaceutical industries. Bulletin of the IDF, 289: 43-53.
• Tarakçı Z. ve E. Küçüköner. 2005. Laktoz, laktoz türevleri ve gıda sanayinde kullanımı. Gıda, 30: 261-267.
• Terada A., Hara H., Kataoka M. and T. Mitsuoka. 1992. Effect of lactulose on the composition and metabolic activity of the human faecal flora. Microbial Ecology in Health and Disease. 5: 43-50.
• Tuohy K.M., Probert H.M., Smejkal C.W. and G.R. Gibson G.R. 2003. Using probiotics and prebiotics to improve gut health. Drug Discov Today, 8: 692-700.
• Underwood M.A., Salzmand N.H., Bennett S.H., Barman M., Mills D.A., Marcobal A., Tancredi D.J., Bevins C.L. and M. Sherman. 2009. A randomized placebo controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: Impact on weight gain, intestinal micro biota and fecal short chain fatty acids. Journal of Pediatric Gastroenterology and Nutrition, 48: 216-225.
• Van der Meulen R., Avonts L. and L.D. Vuyst. 2004. Short fractions of oligofructose are preferentially metabolized by Bifidobacterium animalis DN-173 010. Applied and Environmental Microbiology, 70: 1923-1930.
• Vasiljevic T. and N.P. Shah. 2008. Probiotics-from Metchnikoff to bioactives. International Dairy Journal, 18: 714-728.
• Venema K., Vermunt S.H.F. and E.J. Brink. 2005. D-tagatose increases butyrate production by the colonic microbiota in healthy men and women. Microbial Ecology in Health and Disease, 17: 47-57.
• Wang X. and G.R. Gibson. 1993. Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. Journal of Applied Bacteriology, 75: 373-80.
• Wang J., Sun B., Cao Y. and C. Wang. 2010. In vitro fermentation of xylooligosaccharides from wheat bran insoluble dietary fiber by Bifidobacteria. Carbohydrate Polymers, 82: 419-423.