Preeklampside androgen seviyeleri yüksek mi?

Abstract

Objective: To investigate the androgen levels in preeclamptic pregnancies compared to normotensive cases. Material-methods: Fifty-eight primigravid women with singleton pregnancies were admitted to the study. Thirty cases were diagnosed as preeclampsia and these patients were considered as the study group. The control group consisted of 28 normotensive patients. Maternal venous blood samples were collected. Serum estradiol, total testosterone, sex hormone binding globulin and dehydroepiandrosterone sulfate levels were measured. The GraphPad Instat PC program was used, and the student t-test was performed. Results: There was no statistically significant difference between the control and the study group with respect to maternal age, gestational age and body mas s index. Furthermore, there was no statistically significant difference between the two groups regarding to serum estradiol, total testosterone, sex hormone binding globulin, and dehydroepiandrosterone sulfate levels (p>0.05). Conclusion: This study indicated that there is no difference in androgen hormone levels between the normotensive and the pre e clamptic pregnancie s.

Keywords

• Pregnancy Complications,Pre-Eclampsia,Androgens,Testosterone,Pregnancy Toxemias

Are androgen levels high in preeclampsia

Öz

Amaç: Çalışmanın amacı, preeklamptik gebelerde androjen hormon seviyelerini, tansiyonu normal olan gebeler ile karşılaşnrarak araştırmak. Mateıyalve metod: 58 primigravid teka gebelik olgusu çalışmaya alındı. Preeklampsi tanısı konulan 30 olgu çalışma grubunu oluşturdu. Tansiyonu normal olan 28 gebe ise kontrol grubu olarak alındı. Matemal venöz kanda, serum östradiol, total testosteron, seks hormon bağlayıcı globulin ve dehidroepiandrosteron sülfat seviyelerine bakıldı. GraphPad Instat PC programı kullanıldı, student t-testi uygulandı. Bulgular : Çalışma ve kontrol grubunun maternal yaşı, gebelik haftası ve vücut kütle indeksinde istatistiksel anlamlı farklılık saptanmadı. Her iki grup arasında, serum östradiol, total testosteron, seks hormon bağlayıcı globulin ve dehidroepiandrosteron sülfat düzeylerinde istatistiksel anlamlı farklılık bulunmadı(p >0.05). Sonuç: Preeklamptik gebelerde, serum androjen hormon seviyelerinin, tansiyonu normal gebeler ile farklılık oluşturmadığı sonucuna varıldı.

Anahtar Kelimeler

• Gebelik komplikasyonları,Preeklampsi,Androjenler,Testosteron,Gebelik toksemisi

Kaynakça

1. l~DekkerGA, SibaiBM: Etiology and pathogene s is of preeclampsia: Current concepts. Am J Obstet Gynecol 1998; 179(5): 1359-75
2. 2. Radon PA, McMahon MJ, Meyer WR: Impaired glucose tolerance in pregnant women with polycystic ovary syndrome. Obstet Gynecol 1999; 94(2): 194-7
3. 3. Diamant YZ, Rimon E, Evron S: High incidence of preeclamptic toxemia in patients with polycystic ovarian disease, Eurf Öbstet GynecolRepmd Biol 1982; 14(3): 199-204
4. 4. Sfr-Petermann T, Maliqueo M, Angel B, Lara HE, Perez-Bravo F, Recabarren SE: Maternal serum androgens in pregnant women with polycyst ovarian syndrome: possible implications in prenatal androgenization. Hum Reprod 2002; 17(10): 2573-9
5. 5. Acromite MT, Mantzoros CS, Leach RE, Hurwitz J Dorey LG: Androgens in preeclampsia. Am f Obstel Gynecol 1999; 180: 60-3
6. 6. Serin IS, Kula M, Basbug M, Unluhizarci K, GucerS, Tayyar M: Androgen leveb of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery. Acta Obstet G)mecol Scand 2001; 80(11): 1009-13
7. 7. SteierJA, Ulstein M, Myking OL: Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex. Obstet Gynecol2002; 100(3): 552-6
8. 8. Silver HM, Lambert-Messerlian GM, Star J A, HoganJ, CanickJA: Comparison of maternal serum total activin A and. inhibinAin normal, preeclamptic and nonproteinuric gestationally hypertensive pregnancies. Am J Obstet Gymecol 1999; 180(5): 1131-7

9. 9. Muttukrishna S, Knight PG, Groome NP, Redman CW, Ledger WL: Activin A and inhhinA as possible endocrine markers for preeclampsia. Lancet 1997; 349(9061): 1258-8
10. 10. Pigny P, Desailloud R, Cortet- Rudelli C, Duhamel A, Deroubaix-AUard D, Radacot A, DewaMyD: Serum alpha-inhibin levels in polycystic ovarian syndrome: relationship to the serum androstenedione level. J Cjin Endocrinol Metab 1997; 82(6): 1939-43, 11. HahnelME, Martin JD, Michael CA, HahnelR: Metabolism of androstenedione by placental micros omes in pregnancy hypertension. Clin Chim Acta 1989; 181(1): 103-8
11. 12. Bern MM, Driscoll SG, Leavitt T fr: trombocytopenie complicating preeclampsia: data to support a new model. Obstet Gynecol 1981; 57(6 Suppi): 28S-33S
12. 13. National high blood pressure education program working group on high blood pressure in pregnancy: Report of national high blood pressure education program working group on high blood pressure in pregnancy. Am ] Obstet Gynecol 2000; 183: Sl-S22
13. 14. TakeuchiT, NishiiO, Okamura T, Yaginuma T, Kawana T: Free testosterone and abortion in early pregnancy. M J Gynaecol Obstet 1993; 43(2): 151-6
14. 15. ÖLearyP, Boyne P, FlettP, BeilbyJ, fames I; Longitudinal assessment of changes in reproductive hormones during normal pregnancy. Clin Chem 1991; 37(5): 667-72
15. 16. Bammann BL, Coulam CB, Jiang NS: Total and free testosterone during pregnancy. Am } Obstet Gynecol 1980; 137(3): 293-8
16. 17. Uriel J, Dupiers M, Rimbaut C, Buffe D: Maternal serum levels of sex steroid- binding protein during pregnancy. Br f Obstet Gynaecol 1981; 88(12): 1229-32
17. 18. Innes KE, Byers TE: Preeclampsia and breast cancer risk. Epidemiology 1999; 10(6): 772-32
18. 19. TroisiR, Potischnian N, Roberts JM, Ness R, Crombleholme W, LykD, S Uteri P, Hoover RN: Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies. MJ Epidemiol 2003; 32(3):455-60
19. 20. Laivuori H, Kaaja R, Rutanen EM, Viinikka L, Ylikorkala O: Evidence of high circulating testosterone in women with prior preeclampsia. J 21. Miller NR, Garry D, Cohen HW, Figueroa R: Serum androgen markers in preeclampsia. J Heprod Med 2003; 48(4): 225-9
20. 22. Fıcıcıoglu C, Kutlu T: The role of androgens in the aetiology and pathology of pre-eclampsia. } obstet Gynaecol 2003; 23(2): 134-7
21. 23. NisellH, Erikssen C, Persson B, Carlstrom K: Is carbohydrate metabolism altered among women who have undergone a preeclamptic pregnancy?. Gynecol Obstet Invest 1999; 48(4): 241-6
22. 24. Glass AR, Klein T: Changes in maternal serum total and free androgen levels in early pregnancy: lack of correlation with fetal sex. Am / Obstet Gynecol 1981; 140(6): 656-60
23. 25. Vytiska- Binstorfer E, HuberJC, Spona J: Correlation of maternal androgens in early and late pregnancy. A correlation with fetal size and sex. Zentrabl Gynakol 1988; 110(8): 488-93.