Estrogen and progesteron receptor expression in cellular leiomyomas and leiomyosarcomas

Abstract

Objective:To evaluate estrogen(ER) and progesteron(PR) receptor expression in cellular leiomyomas and leiomyosarcomas Materials and Methods: The study includes 17 cases of cellular leiomyoma(CM) and 7 cases of leiomyosarcoma(LMS) which were diagnosed in Pathology Department of Zeynep Kamil Hoşpital between 1997 and 2003 years. One paraffin-embedded tümör tissue per each case were analyzed immunohistochemically for ER and PR ,receptors. Results: None of LMSs showed 'overexpression' for PR. Out-of 17 CMs 13 showed PR overexpression.(LMS PR overexpressionxCMPR overexpression,p

Keywords

• Leiomyoma,Leiomyosarcoma,Receptors, Estrogen,Receptors, Progesterone

Selüler leiomyon ve leiomyosarkomlarda östrojen ve progesteron reseptör ekspresyonu

Öz

Amaç: Selüler leiomyom ve leimyo sarkomların Ostrojen ve progesteron reseptör ekspresyonlarını değerlendirmek. Materyal ve Method: 1997-2003 yıUarı arasında Zeynep Kamil Hastanesi Patoloji Bölümünde tanı almış 17 selüler leimyom ve 7 leiomyosarkom olgusu çalışma kapsamına alındı. Tümörleri temsil eden birer parafin blokda immunhisto kimyasal yöntemle östrojen ve progesteron reseptör boyanması incelendi. Bulgular: Leiomy'Osarkomların hiçbirinde progesteron resptörü için "overexpression"'(OE) izlenmedi. Onyedi adet selüler leibmyomun 13 ünde OE saptandı (LMS PR-OE x SM PR-OE, p

Anahtar Kelimeler

• Leyomiyom,Leyomiyosarkom,Reseptörler, östrojen,Reseptörler, progesteron

Kaynakça

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