Does endometrium thickness predict clinical pregnancy in ICSI-ET?

Abstract

Does endometrium thickness predict clinical pregnancy in ICSI-ET? Although thickness of the endometrium is important for successful implantation and pregnancy, controversy exists on the clinical significance ofvariation in endometrial thickness observed among patients undergoing assisted reproduction. The aim of this retrospective study was to evaluate the predictive value of endometrium thickness measured by ultrasonography in patients undergoing Intracytoplasmic sperm injection (ICSI). Endometrium levels were measured by ultrasonography in a total of 103 pregnant and non-pregnant patients in on the day of hCG administration. According to our results endometrial thickness do not have a predictive value to determine pregnancy in ICSI cycles.

Keywords

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Endometrium kalınlığı ICSI sonrası gebeliğin belirlenmesinde predikdif midir?

Öz

Endometriyum kalınlığının gebeliğin oluşması ve implantasyon için önemli olduğu bilinmekle birlikte, infertilite nedeniyle IVF tedavisine alınan hastalarda endometriyum kalınlığının klinik önemi ile ilgili farklı görüşler bildirilmiştir. Çalışmamızda retrospektifolarak, infertilite tedavisine alınan ve ICSI (intracytoplasmic sperm injection) tedavisi uygulanan hastalarda ultrasonografi ile ölçülen endometriyum kalınlığının gebelik için prediktif değerini belirlemeyi amaçladık. Bu amaçla ICSI tedavisi sonrasında gebelik oluşan ve oluşmayan 103 hastanın hCG (human chorionic gonadotropin) günü ultrasonografi ile ölçülen endometriyum seviyeleri belirlendi. Bulgularımız, endometriyum kalınlığının ICSI sonrası gebeliğin belirlenmesinde prediktif değere sahip olmadığı sonucunu ortaya çıkarmıştır.

Anahtar Kelimeler

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Kaynakça

1. 1. Steven R Bayer ,Michael M.Alper ,Alan SPenzıas Handbook of infertility. The Boston IVF Second Edition, 2007
2. 2. Kovacs P, Matyas S, Boda K, Kaali SG. The effect of endometrial thickness on IVF/ICSI outcome. Hum Reprod. 2003;18:2337-2341
3. 3. Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995;10: 919-922
4. 4. Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH. Endometrial pattern and thickness associated withpregnancy outcome after assisted reproduction technologies. Hum Reprod. 1992; 7: 418-421
5. 5. Rashidi BH, Sadeghi M, Jafarabadi M, Tehrani Nejad ES. Relationships betweenpregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern. Eur J Obstet Gynecol Reprod Biol. 2005;120:179-184
6. 6. Yuval Y, Lipitz S, Dor J, Achiron R. The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization. Hum Reprod. 1999;14: 1067-1071
7. 7. Bassil S. Changes in endometrial thickness, width, length andpattern inpredictingpregnancy outcome during ovarian stimulation in in vitro fertilization. Ultrasound Obstet Gynecol. 2001;18: 258-263
8. 8. Laasch C, PuscheckE. Cumulative embryo score, not endometrial thickness, is best for pregnancy prediction in IVF. J Assist Reprod Genet. 2004; 21: 47-50

9. 9. Oliveira JB, BaruffiRL, Mauri AL, Petersen CG, Borges MC, Franco JG. Endometrial ultrasonography as a predictor of pregnancy in an n-vitro fertilization programme after ovarian stimulation and gonadotrophin-releasing hormone and gonadotrophins. Hum Reprod. 1997; 12: 2515-2518
10. 10. Liu HM, Xing FQ, Chen SL, Li H. Predictive value ofendometrial ultrasonography and agefor the outcome of in vitro fertilization-embryo transfer. Di YiJun Yi DaXueXueBao. 2005; 25: 570-572
11. 11. Schild RL, Knobloch C, Dorn C, Fimmers R, van der Ven H, Hansmann M. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001;75: 361-366
12. 12.Van Steirteghem, A. C., Liu, J., Joris, H., Nagy, Z, Janssenswillen, C., Tournaye, H., Derde, M. P., Van Assche, E. & Devroey, P. Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Human Reproduction 8, 1993; 1055-1060
13. 13.Richter KS, Bugge Kr, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. 2007; 87(1):53-9
14. 14. Weissman , Gotlieb L, Casper RF. The detrimental effect of increased endometrial thickness on implantation and pregnancy rates and outcome in an in vitro fertilization program. Fertil Steril. 1999; 71:147-149
15. 15. Dietterich C, J H, J K, Nazari A. Increased andometrial thickness on the day of human chorionic gonadotropin injection does not adversely affectpreagnancy or implantation ratesfollowing in vitro fertilization-embryo transfer.Fertil Steril. 2002; 77: 781-786