Reactive oxygen species and antioxidants in semen

Abstract

The role of oxygen toxicity and free radical reactions (reactive oxygen species) in association wity fertility potential is known. All cellular elements such as lipids,proteins, nucleic acids and sugars are known to be the potential targets for these radicals. Cytotoxicity of reactive oxygen species is held in check by the delicate balance between their rates of generation and the rate of their removal. Any shift in this equilibrium can lead to cellular damage. The ability of the spermatozoa to prevent lipid peroxidation is of critical importance in maintaining proper function and stability of the cell membrane. Intra and extracellular scavenger systems (antioxidants) serve to prevent the potential toxic effects of reactive oxygen species. Therefore dietary and supplement intake of antioxidants and treating spermatozoa with solutions containing antioxidants during the preparation of semen should be advised during infertility treatment.

Keywords

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Semende reaktif oksijen türevleri ve antioksidanlar

Öz

Fertilite potansiyeli ile oksijen toksisitesi ve serbest radikallerin (reaktif oksijen türevleri) ilişkisi bilinmektedir. Yağlar, proteinler, nükleik asitler ve şekerler gibi tüm hücresel yapılar reaktif oksijen türevleri için potansiyel hedeflerdir Reaktif oksijen radikallerinin sitotoksisitesi üretilme veyokedilme oranları arasındaki hassas denge sonucu belirlenmektedir. Bu dengedeki herhangi bir bozukluk hücresel zarara neden olmaktadır. Spermatozoaların lipid peroksidasyonundan korunmaları bu hücrelerin fonksiyonlarını doğru bir şekilde yerine getirebilmeleri ve hücre zarlarının devamlılığını koruyabilmeleri açısından çok büyük önem taşımaktadır. Bu durum teorik olarak O2-ve H2O2 seviyeleri sınırlandırılarak, metal katalizörlerinin varlığı sınırlandırarak ve peroksidasyon başladığı anda durdurularak sağlanabilir. Hücre içi ve dışı koruma sistemleri (antioksidanlar) bu amaçla hizmet eden ve serbest radikallerin potansiyel toksik etkilerine karşı hücreyi koruyan mekanizmalardır. Spermatozoonların oksidatifzarar görmemesiya da mümkün olduğunca az zarar görmesi için infertilite tedavisinde diyetle antioksidan alımıya da antioksidan içeren medyumların sperm hazırlama tekniklerinde kullanımı önerilebilir.

Anahtar Kelimeler

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Kaynakça

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