Determination of Optimum Transfer Day According to Mother's Age in Frozen-Thawed Embryo Cycles

Yıl 2018, , 133 - 135, 04.04.2018

Seda Karabulut , Oya Korkmaz , Nuri Delikara İlknur Keskin

https://doi.org/10.16948/zktipb.332476

Öz

Aim: In this study, it was aimed to
investigate the effect of transfer day according to maternal age in frozen
embryo transfer cycles to determine which age group and which embryo transfer
day is optimum.

Material and Method: 205 couples
were retrospectively analyzed and included in the study. Patients were divided
into 3 groups according to the maternal age. The first group consisted of 63
patients under 30 years old, the second group consisted of 109 patients between
30 - 37 years old, and third group consisted of 33 patients higher than 37
years of age. Patients in each group were separated according to the day of embryo
transfer whether on the 3rd or 5th day and pregnancy rates were determined.

Results: Although there were no statistically
significant difference between pregnancy rates in the first and second groups
(38.7%, 31.2% and 31.6%, 30.6 % respectively), the success rate of the 3rd day
transfer in group 3 was about 2.5 times higher than in the fifth day ET group (28%
- 12.5% respectively).

Conclusion: It was observed that in the patients
under the age of 30 and between the ages of 30-37, the day of transfer did not
affect the outcome but in the advanced age group of 37 years embryo transfers
on the third day gave better pregnancy results.

Anahtar Kelimeler

Frozen-Thawed Embryo Transfer, Embryo Development, ICSI, Blastocyst

Dondurulmuş- Çözülmüş Embriyo Sikluslarında Anne Yaşına Göre Optimum Transfer Gününün Belirlenmesi

Öz

Amaç: Bu çalışmamızda, dondurma çözme
sikluslarında anne yaşına göre transfer gününün etkisini inceleyerek hangi yaş
grubunda hangi embriyo transfer gününün daha etkili olduğunun araştırılması
amaçlanmıştır.

Materyal ve Method: 205 çift
retrospektif olarak incelenerek çalışmaya alınmıştır.  Hastalar anne yaşına göre 3 gruba
bölünmüştür. Birinci grup 30 yaş altı 63 hastadan, 2. grup 30-37 yaşa arası 109
hastadan ve 3. grup 37 yaşından büyük 33 hastadan oluşmuştur. Her bir gruptaki
hastalar embriyo transferlerinin 3. ya da 5. günde yapılmış olmasına bağlı
olarak ayrılmış ve gebelik oranları belirlenmiştir.

Bulgular: 1. ve 2. gruplarda gebelik oranları arasında istatistiksel olarak anlamlı bir fark
belirlenmemesine karşılık (%38.7, %31.2 ve %31.6, %30.6 sırasıyla) 3. grupta 3.
gün transferindeki başarı oranının 5. güne göre yaklaşık 2.5 kat daha fazla
olduğu (%28 - %12.5 sırasıyla) belirlenmiştir.

Sonuç: 30 yaş altı ve 30-37 yaş arası
hastalarda transfer gününün sonuçları etkilemediği ancak 37 yaşından büyük
ileri yaş grubunda 3. gün embriyo transferlerinin daha iyi gebelik sonucu
verdiği gözlemlenmiştir.

Anahtar Kelimeler

Dondurma Çözme Embriyo Transferi, Embriyo Gelişimi, ICSI, Blastosist

Kaynakça

• Van Steirteghem AC, Liu J, Joris H, Nagy Z, Janssenswillen C, Tournaye H, Derde MP, Van Assche E, Devroey P. Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum Reprod. 1993 Jul;8(7):1055-60.
• De Vos A, Van Landuyt L, Santos Ribeiro S, Camus M, Van de Velde H, Tournaye H, Verheyen G. Cumulative live birth rates after fresh and vitrified cleavage-stage versus blastocyst-stage embryo transfer in the first treatment cycle. Hum Reprod. 2016 Nov;31(11):2442-2449.
• Veeck LL, Bodine R, Clarke RN, Berrios R, Libraro J, Moschini RM, Zaninovic N, Rosenwaks Z. High pregnancy rates can be achieved after freezing and thawing human blastocysts. Fertil Steril. 2004 Nov;82(5):1418-27.
• El-Toukhy T, Kopeika JY, Beebeejaun Y, El Tokhy O, Pundir J, Khalaf Y. Impact of the outcome of fresh blastocyst transfer on the subsequent frozen-thawed blastocyst transfer cycle. Reprod Biomed Online. 2017 Jul 13. pii: S1472-6483(17)30313-9.
• Sun L, Chen ZH, Yin MN, Deng Y.[Pregnancy and obstetric outcomes of fresh embryo transfer versus frozen-thawed embryo transfer in women below 35 years of age].Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):929-932.
• Wang X, Du M, Guan Y, Wang B, Zhang J, Liu Z. Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2017 May 4;15(1):36.
• Adeviye Erşahin A, Acet M(2), Erşahin SS, Dokuzeylül Güngör N. Frozen embryo transfer prevents the detrimental effect of high estrogen on endometrium receptivity. J Turk Ger Gynecol Assoc. 2017 Mar 15;18(1):38-42.
• Carvalho BR, Barbosa MW, Bonesi H, Gomes DB Sobrinho, Cabral ÍO, Barbosa AC, Silva AA, Iglesias JR, Nakagawa HM. Embryo stage of development is not decisive for reproductive outcomes in frozen-thawed embryo transfer cycles. JBRA Assist Reprod. 2017 Feb 1;21(1):23-26.