Araştırma Makalesi
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Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum

275 - 280, 07.09.2018
https://doi.org/10.16948/zktipb.454539

Öz

Giriş

               Fetal ve maternal sağlığa olumlu
etkileri olması nedeniyle gebelik döneminde artan ihtiyaçla orantılı olarak
vitamin ve mineral desteğine ihtiyaç vardır. Bu
çalışmada mikro besin takviyesi olarak D vitamini, Kalsiyum (Ca) ve Magnezyum
(Mg) desteği alan gebelerin postnatal sonuçlarını ve gebelik komplikasyonlarını
araştırmak amaçlandı.

 

Materyal ve Metod

 

               Yapılan bu prospektif, longitudinal
ve kalitatif çalışmaya Ocak 2016 ve Ocak 2018 tarihleri arasında 18-40 yaş arası toplam 2114 hasta
dahil edilmiştir

 

Bulgular

 

Maternal
yaş aralığı tüm hasta grupları için 28.11 ± 6.12‘ dir. Multivitamin kullanan
grubun yaş ortalaması D vitamini grubuna göre daha düşük saptandı(p= 0.001). Yalnızca
Mg ve D vitamini kullanan grupta yüksek lisans seviyesinde eğitim görenler daha
fazlaydı(p=0.001). Mg, Ca, D vitamini ve multivitamin kullananımı ile
gebelik komplikasyonları arasında anlamlı ilişki bulunamadı. Multivitamin
kullanan gebelerde LGA daha fazla görüldü
(p=0.038). İlk gebelik yaşı Ca ve
mulivitamin kullanan grupta Mg ve D vitamini kullanan gruba göre daha düşük

bulunmuştur
(p=0.001).

 

Sonuç

 



























            Annenin sağlıklı bir gebelik
geçirmesi, maternal komplikasyonlardan korunması, fetusun büyüme ve gelişmesi
için annenin düzenli beslenmesinin yanı sıra vitamin ve mineral takviyesi
önemlidir. Bu takviyelerin literatürde gösterilmiş olan yararlarını desteklemek
ve rutin kullanımda yer vermek için daha çok prospektif çalışmaya ihtiyaç
vardır.

Kaynakça

  • ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011; 118:197. Reaffirmed 2017.
  • De-Regil, L. M., Palacios, C., Lombardo, L. K., & Peña-Rosas, J. P. Vitamin D supplementation for women during pregnancy. Sao Paulo Medical Journal, 2016, 134.3: 274-275.
  • Institute of Medicine. Report at a Glance, Report Brief: Dietary reference intakes for calcium and vitamin D, released 11/30/2010. Http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Report-Brief.aspx (Accessed on December 01, 2010).
  • Brannon PM. Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc 2012; 71:205 – 212.
  • Gustafsson MK., Romundstad PR., Stafne SN., Helvik AS., Stunes AK., Mørkved S., et all. Alterations in the vitamin D endocrine system during pregnancy: A longitudinal study of 855 healthy Norwegian women. PloS one, 2018, 13.4: e0195041.
  • Pérez-López FR., Pasupuleti V., Mezones-Holguin E., Benites-Zapata VA., Thota P., Deshpande A. et all. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility, 2015, 103.5: 1278-1288. e4.
  • TC Sağlık Bakanlığı. Gebelere D Vitamini Destek Programı: http://www.saglik.gov.tr/TR/belge/1-12656/ gebelere-d-vitamini-destek-programi.html 1 Ocak 2011
  • Kovacs, Christopher S. Calcium and bone metabolism disorders during pregnancy and lactation. Endocrinology and Metabolism Clinics, 2011, 40.4: 795-826.
  • Yeşiltepe-Mutlu G., Hatun Ş. Perinatal D vitamini yetersizliği. Çocuk Sağlığı ve Hastalıkları Dergisi 2011; 54: 87-98
  • Villar J. , Belizan J. , Fisher P. Kalsiyum alımı ve eklampsi arasındaki ilişki üzerine epidemiyolojik gözlem . Uluslararası Jinekoloji ve Obstetrik Dergisi 1983 ; 21 : 271 - 278.
  • McNamara HC, Crowther CA, Brown J. Different treatment regimens of magnesium sulphate for tocolysis in women in preterm labour. Cochrane Database Syst Rev 2015;12:CD011200.
  • Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(suppl 1):i3–i14.
  • Becker W, Lyhne N, Pedersen AN, Aro A, Fogelholm M, Phorsdottir I, et all. Nordic nutrition recommendations 2004‐integrating nutrition and physical activity. Scand J Nutr 2004;48:178‐87.
  • Wynn A, Wynn M. Magnesium and other nutrient de ciencies as possible causes of hypertension and low birthweight. Nutr Health 1988;6:69‐88.
  • Zarean E., Tarjan A. Effect of magnesium supplement on pregnancy outcomes: a randomized control trial. Advanced biomedical research, 2017, 6.
  • Arikan G., Guecer F., Schoell W., Weiss P. Preterm labour during oral magnesium supplementation in uncomplicated pregnancies. Geburtshilfe Frauenheilkd.1997;57:491-5.
  • World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation Part 1: Diagnosis and Classification of Diabetes Mellitus, 2nd ed. Geneva, Switzerland: World Health Organization; 1999. (WHO/NCD/NCS/99).
  • Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102(1):181–192.
  • Gardosi J., Mongelli M., Wilcox M., Chang A. An adjustable Fetal Weight Standard. Ultrasound Obstet Gynecol 1995; 6: 168–74.
  • Bhutta ZA., Haider BA. Prenatal micronutrient supplementation: Are we there yet? CMAJ 2009, 180, 1188–1189.
  • Darnton-Hill I., Mkparu UC. Micronutrients in pregnancy in low-and middle-income countries. Nutrients, 2015, 7.3: 1744-1768.
  • Darnton-Hill I., Webb P., Harvey PWJ., Hunt JM., Dalmiya N., Chopra M., et all. Micronutrient deficiencies and gender: Social and economic costs. Am. J. Clin. Nutr. 2005, 819, 1198S–1205S.
  • Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84.
  • Mercer BM., Merlino AA. Magnesium sulfate for preterm labor and preterm birth. Obstet Gynecol. 2009;114:650–668.
  • Uludag EU, Gozukara IO, Kucur SK, Ulug P., Ozdegirmenci O., Erkaya S. Maternal magnesium level effect on pre- term labor treatment. J Matern Fetal Neonatal Med. 2014;27:1449–1453.
  • Hsu WY., Wu CH., Hsieh CT., Lo HC., Lin JS., Kao MD. Low body weight gain, low white blood cell count and high serum ferritin as markers of poor nutrition and increased risk for preterm delivery. Asia Pac J Clin Nutr. 2013;22:90–99.
  • Ortega RM., Martinez RM., Lopez-Sobaler AM., Andres P., Quintas ME. Influence of calcium intake on gestational hypertension. Annals of Nutrition and Metabolism 1999; 43:37–46.
  • Hofmeyr GJ., Atallah AN., Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Data- base Syst Rev. 2006;(3):CD001059.
  • Buppasiri P., Lumbiganon P., Thinkhamrop J., Ngamjarus C., Laopaiboon M., Medley N. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. The Cochrane Library, 2015.
  • Haider BA., Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev, 2015, 11.4.
  • Fall CH., Fisher DJ., Osmond C., Margetts BM. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food Nutr Bull, 30 (2009), pp. S533-S546.
  • Imdad A., Jabeen A., Bhutta ZA. Role of calcium supplementation during preg- nancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries. BMC Public Health. 2011; 11(Suppl 3):S18.
  • Ma R., Gu Y., Zhao S, Sun J., Groome LJ., Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocri- nol Metab 2012;303:E928–35.
  • Bener A., Al-Hamaq AO., Saleh NM. Association between vitamin D insuffi- ciency and adverse pregnancy outcome: global comparisons. Int J Womens Health 2013; 5:523 – 531.
  • Wamberg L., Christiansen T., Paulsen SK., Fisker S., Rask P., Rejnmark L., et all. Expression of vitamin D-metabolizing enzymes in human adipose tissue— the effect of obesity and diet-induced weight loss. Int J Obes (Lond) 2013; 37:651–7.

Effects of Micronutrient Supplement on Maternal and Fetal Outcomes: Vitamin D, Calcium and Magnesium

275 - 280, 07.09.2018
https://doi.org/10.16948/zktipb.454539

Öz

Introduction

 

Due to the positive effects on fetal and
maternal health, there is an increased need for vitamin and mineral supplements
during pregnancy. In this study, it was aimed to investigate the postnatal
outcomes and pregnancy complications of pregnant women who received vitamin D
supplementation, calcium (Ca) and magnesium (Mg) as micronutrient supplement.

 

Materials and Methods

 

A total of 2114 patients aged between 18
and 40 years were included in this prospective, longitudinal and qualitative
study between January 2016 and January 2018.

 

Results

 

The mean maternal age was 28.11 ± 6.12
for all patient groups. The mean age of the group received multivitamins was
lower than the vitamin D group (p = 0.001). In the group receiving only Mg and
vitamin D supplements, the number of postgraduate educated patients were
more  (p = 0.001). There was no significant relationship between Mg, Ca, 
vitamin D  and multivitamin use and pregnancy complications. LGA was more
frequent in multivitamin-using group (p = 0.038). The first gestational age was
found to be lower in Ca and multivamine group compared to the group receiving
Mg and vitamin D supplement (p = 0.001).

 

Conclusion

 





























Vitamin and mineral supplementation as
well as the regular daily nutrition is important not only for women to have a
healthy pregnancy period without any maternal complications but also for growth
and development of the fetus. More prospective studies with larger population
are needed for supporting the benefits of these supplements and suggest their
routine usage.

Kaynakça

  • ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011; 118:197. Reaffirmed 2017.
  • De-Regil, L. M., Palacios, C., Lombardo, L. K., & Peña-Rosas, J. P. Vitamin D supplementation for women during pregnancy. Sao Paulo Medical Journal, 2016, 134.3: 274-275.
  • Institute of Medicine. Report at a Glance, Report Brief: Dietary reference intakes for calcium and vitamin D, released 11/30/2010. Http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Report-Brief.aspx (Accessed on December 01, 2010).
  • Brannon PM. Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc 2012; 71:205 – 212.
  • Gustafsson MK., Romundstad PR., Stafne SN., Helvik AS., Stunes AK., Mørkved S., et all. Alterations in the vitamin D endocrine system during pregnancy: A longitudinal study of 855 healthy Norwegian women. PloS one, 2018, 13.4: e0195041.
  • Pérez-López FR., Pasupuleti V., Mezones-Holguin E., Benites-Zapata VA., Thota P., Deshpande A. et all. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility, 2015, 103.5: 1278-1288. e4.
  • TC Sağlık Bakanlığı. Gebelere D Vitamini Destek Programı: http://www.saglik.gov.tr/TR/belge/1-12656/ gebelere-d-vitamini-destek-programi.html 1 Ocak 2011
  • Kovacs, Christopher S. Calcium and bone metabolism disorders during pregnancy and lactation. Endocrinology and Metabolism Clinics, 2011, 40.4: 795-826.
  • Yeşiltepe-Mutlu G., Hatun Ş. Perinatal D vitamini yetersizliği. Çocuk Sağlığı ve Hastalıkları Dergisi 2011; 54: 87-98
  • Villar J. , Belizan J. , Fisher P. Kalsiyum alımı ve eklampsi arasındaki ilişki üzerine epidemiyolojik gözlem . Uluslararası Jinekoloji ve Obstetrik Dergisi 1983 ; 21 : 271 - 278.
  • McNamara HC, Crowther CA, Brown J. Different treatment regimens of magnesium sulphate for tocolysis in women in preterm labour. Cochrane Database Syst Rev 2015;12:CD011200.
  • Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(suppl 1):i3–i14.
  • Becker W, Lyhne N, Pedersen AN, Aro A, Fogelholm M, Phorsdottir I, et all. Nordic nutrition recommendations 2004‐integrating nutrition and physical activity. Scand J Nutr 2004;48:178‐87.
  • Wynn A, Wynn M. Magnesium and other nutrient de ciencies as possible causes of hypertension and low birthweight. Nutr Health 1988;6:69‐88.
  • Zarean E., Tarjan A. Effect of magnesium supplement on pregnancy outcomes: a randomized control trial. Advanced biomedical research, 2017, 6.
  • Arikan G., Guecer F., Schoell W., Weiss P. Preterm labour during oral magnesium supplementation in uncomplicated pregnancies. Geburtshilfe Frauenheilkd.1997;57:491-5.
  • World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation Part 1: Diagnosis and Classification of Diabetes Mellitus, 2nd ed. Geneva, Switzerland: World Health Organization; 1999. (WHO/NCD/NCS/99).
  • Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102(1):181–192.
  • Gardosi J., Mongelli M., Wilcox M., Chang A. An adjustable Fetal Weight Standard. Ultrasound Obstet Gynecol 1995; 6: 168–74.
  • Bhutta ZA., Haider BA. Prenatal micronutrient supplementation: Are we there yet? CMAJ 2009, 180, 1188–1189.
  • Darnton-Hill I., Mkparu UC. Micronutrients in pregnancy in low-and middle-income countries. Nutrients, 2015, 7.3: 1744-1768.
  • Darnton-Hill I., Webb P., Harvey PWJ., Hunt JM., Dalmiya N., Chopra M., et all. Micronutrient deficiencies and gender: Social and economic costs. Am. J. Clin. Nutr. 2005, 819, 1198S–1205S.
  • Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84.
  • Mercer BM., Merlino AA. Magnesium sulfate for preterm labor and preterm birth. Obstet Gynecol. 2009;114:650–668.
  • Uludag EU, Gozukara IO, Kucur SK, Ulug P., Ozdegirmenci O., Erkaya S. Maternal magnesium level effect on pre- term labor treatment. J Matern Fetal Neonatal Med. 2014;27:1449–1453.
  • Hsu WY., Wu CH., Hsieh CT., Lo HC., Lin JS., Kao MD. Low body weight gain, low white blood cell count and high serum ferritin as markers of poor nutrition and increased risk for preterm delivery. Asia Pac J Clin Nutr. 2013;22:90–99.
  • Ortega RM., Martinez RM., Lopez-Sobaler AM., Andres P., Quintas ME. Influence of calcium intake on gestational hypertension. Annals of Nutrition and Metabolism 1999; 43:37–46.
  • Hofmeyr GJ., Atallah AN., Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Data- base Syst Rev. 2006;(3):CD001059.
  • Buppasiri P., Lumbiganon P., Thinkhamrop J., Ngamjarus C., Laopaiboon M., Medley N. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. The Cochrane Library, 2015.
  • Haider BA., Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev, 2015, 11.4.
  • Fall CH., Fisher DJ., Osmond C., Margetts BM. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food Nutr Bull, 30 (2009), pp. S533-S546.
  • Imdad A., Jabeen A., Bhutta ZA. Role of calcium supplementation during preg- nancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries. BMC Public Health. 2011; 11(Suppl 3):S18.
  • Ma R., Gu Y., Zhao S, Sun J., Groome LJ., Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocri- nol Metab 2012;303:E928–35.
  • Bener A., Al-Hamaq AO., Saleh NM. Association between vitamin D insuffi- ciency and adverse pregnancy outcome: global comparisons. Int J Womens Health 2013; 5:523 – 531.
  • Wamberg L., Christiansen T., Paulsen SK., Fisker S., Rask P., Rejnmark L., et all. Expression of vitamin D-metabolizing enzymes in human adipose tissue— the effect of obesity and diet-induced weight loss. Int J Obes (Lond) 2013; 37:651–7.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Ozan Doğan 0000-0002-0016-8749

Aşkı Ellibeş Kaya 0000-0002-1323-7416

Çiğdem Pulatoğlu 0000-0002-7595-3629

Bertan Akar 0000-0003-0494-6867

Alper Başbuğ 0000-0003-1825-9849

Eray Çalışkan 0000-0002-6799-5909

Yayımlanma Tarihi 7 Eylül 2018
Yayımlandığı Sayı Yıl 2018

Kaynak Göster

APA Doğan, O., Ellibeş Kaya, A., Pulatoğlu, Ç., Akar, B., vd. (t.y.). Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum. Zeynep Kamil Tıp Bülteni, 49(3), 275-280. https://doi.org/10.16948/zktipb.454539
AMA Doğan O, Ellibeş Kaya A, Pulatoğlu Ç, Akar B, Başbuğ A, Çalışkan E. Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum. Zeynep Kamil Tıp Bülteni. 49(3):275-280. doi:10.16948/zktipb.454539
Chicago Doğan, Ozan, Aşkı Ellibeş Kaya, Çiğdem Pulatoğlu, Bertan Akar, Alper Başbuğ, ve Eray Çalışkan. “Mikro Besin Takviyesinin Maternal Ve Fetal Sonuçlara Etkisi: D Vitamini, Kalsiyum Ve Magnezyum”. Zeynep Kamil Tıp Bülteni 49, sy. 3 t.y.: 275-80. https://doi.org/10.16948/zktipb.454539.
EndNote Doğan O, Ellibeş Kaya A, Pulatoğlu Ç, Akar B, Başbuğ A, Çalışkan E Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum. Zeynep Kamil Tıp Bülteni 49 3 275–280.
IEEE O. Doğan, A. Ellibeş Kaya, Ç. Pulatoğlu, B. Akar, A. Başbuğ, ve E. Çalışkan, “Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum”, Zeynep Kamil Tıp Bülteni, c. 49, sy. 3, ss. 275–280, doi: 10.16948/zktipb.454539.
ISNAD Doğan, Ozan vd. “Mikro Besin Takviyesinin Maternal Ve Fetal Sonuçlara Etkisi: D Vitamini, Kalsiyum Ve Magnezyum”. Zeynep Kamil Tıp Bülteni 49/3 (t.y.), 275-280. https://doi.org/10.16948/zktipb.454539.
JAMA Doğan O, Ellibeş Kaya A, Pulatoğlu Ç, Akar B, Başbuğ A, Çalışkan E. Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum. Zeynep Kamil Tıp Bülteni.;49:275–280.
MLA Doğan, Ozan vd. “Mikro Besin Takviyesinin Maternal Ve Fetal Sonuçlara Etkisi: D Vitamini, Kalsiyum Ve Magnezyum”. Zeynep Kamil Tıp Bülteni, c. 49, sy. 3, ss. 275-80, doi:10.16948/zktipb.454539.
Vancouver Doğan O, Ellibeş Kaya A, Pulatoğlu Ç, Akar B, Başbuğ A, Çalışkan E. Mikro Besin Takviyesinin Maternal ve Fetal Sonuçlara Etkisi: D vitamini, Kalsiyum ve Magnezyum. Zeynep Kamil Tıp Bülteni. 49(3):275-80.