PEDİATRİK ALL’DE RAS/RAF/MEK/ERK YOLAĞINA MOLEKÜLER BİR BAKIŞ

Öz

Pediatrik löseminin henüz sebebi kesin olarak bilinmeyen ancak tedavi edilebilen, multifaktöriyel bir hastalık olduğu düşünülmektedir. Lösemilerde diğer birçok kanser türü gibi genetik değişimler söz konusudur.  Onkogenlerin aktivasyonu ya da tümör baskılayıcı genlerin inaktivasyonunda etkili bu genetik lezyonlar; hücre ölümü, farklılaşma ya da bölünmenin düzenlenme mekanizmalarında hasara yol açarak lösemi gelişimine neden olabilirler. Henüz belirlenmemiş genetik anomalilerin bilinmesi bu basamaklara etki eden tedavi seçeneklerinin bulunması ve bu sayede kemoterapiye dirençli ve nüks gösteren lösemilerin tedavi edilmesine, kişiselleştirilmiş tedavi yöntemlerinin geliştirilmesine olanak sağlamaktadır. Bu derlemede kanser gelişiminde önemli olduğu yapılan çalışmalar neticesinde ortaya konulan RAS/RAF/MEK/ERK yolağının pediatrik lösemi alt türü olan Akut Lenfoblastik Lösemi’de (ALL) incelenme yaklaşımını ortaya koyabilmek amaçlanmıştır.

Anahtar Kelimeler

• Lösemi,pediatri,biyobelirteç,gen

A MOLECULAR VIEW OF RAS /RAF/MEK /ERK IN PEDIATRIC ALL

Abstract

Pediatric leukemia is thought to be a multifactorial disease that can be treated.In leukemia there are genetic changes like many other types of cancer. 

These genetic changes are effective in the activation of oncogenes or inactivation of tumor suppressor genes; can lead to the development of leukemia by causing damage to regulatory mechanisms of cell death, differentiation or division. Unspecified genetic anomalies provide the availability of treatment options that affect these steps of cell cycle. It provied that treatment of chemotherapy-resistant and relapsing leukemia and the development of personalized treatment modalities In this review, we aimed to reveal the approach of the RAS / RAF / MEK / ERK pathway revealed in the studies that are important in the development of cancer in Acute Lymphoblastic Leukemia (ALL), a subtype of pediatric leukemia.

Keywords

• Leukemia,pediatric,gene,marker

Kaynakça

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