LVSI pozitif ve grade 1-2 tümörü olan evre IA ve evre IB endometrial kanser hastalarının karşılaştırılması: 2016 yılında ESMO-ESGO-ESTRO tarafından tanımlanmış olan yüksek-orta risk grubunun analizi

Yıl 2019, , 112 - 116, 15.09.2019

Koray Aslan , İbrahim Yalçın Hanifi Şahin , Mehmet Mutlu Meydanlı

https://doi.org/10.16948/zktipb.585846

Öz

Giriş: Endometrial kanserinde, nüks riski olan
hastaları belirlemek ve adjuvan tedavi kullanımına rehberlik etmek amacı ile
klinik-patolojik prognostik faktörler kullanılarak risk grupları
oluşturulmuştur. Güncel yayınlanan rehberde yeni bir risk grubu tanımlanmış
olup evre I endometrioid karsinom, grade 1-2 hastalık ve LVSI pozitif olan
olgular myometrial invazyon derinliğinden bağımsız olarak “orta-yüksek” riskli
olarak sınıflandırılmıştır. Bu retrospektif çalışmanın amacı evre IA
yüksek-orta riskli endometrial kanserli kadınların prognozlarını evre IB
Yüksek-orta riskli endometrial kanserli kadınlarla karşılaştırmaktır.

Metot: Retrospektif tek merkezli olarak planlanan
çalışmada, 2008-2018 tarihleri arasında endometrium kanseri tanısı ile primer
tedavi olarak cerrahi ile tedavi edilen tüm hastalar incelendi. Çalışmaya evre
I endometroid tip endometrium kanseri olup, LVSI pozitif ve grade 1-2 tümörü
olan toplam 46 olgu dahil edildi. Çalışmaya dahil edilen 17 olgu evre IA ve 29
olgu evre IB olmak üzere gruplandırıldı. Olgular için sağ kalım analizleri
Kaplan Meier metodu kullanılarak hesaplandı.   

Bulgular: 5-yıllık DFS oranı evre
IA olgular için %94,1 ve evre IB olgular için % 82,3 (p=0.951),5- yıllık OS
oranı evre IA olgular için % 94,1 ve evre IB olgular için % 89 (p=0.811) olarak
belirlenmiştir. 

Sonuç: Evre IA, grade 1-2 ve LVSI
pozitif endometrial kanserli olgular ve Evre IB, grade 1-2 ve LVSI pozitif
endometrial kanserli olguların DFS ve OS oranlarının benzer olduğu görülmüştür.

Anahtar Kelimeler

Endometrium kanseri, LVSI, Sağkalım

Comparison of stage IA and stage IB endometrial cancerpatients who were unequivocally LVSI positive and grade 1-2: Analysis of High Intermediate risk group which was currently defined by ESMO-ESGO-ESTRO Consensus in 2016

Öz

Objective: The patients with endometrial cancer have been devised
based on clinic-pathological prognostic factors to identify patients at the
risk of recurrence and to guide adjuvant therapy use. According to contemporary
guidelines, a new risk subgroup has been declared. Regardless of depth of
invasion, all patients who were unequivocally LVSI positive and grade 1-2
defined as High-intermediate risk group. The purpose of this retrospective study was to compare
the prognoses of women with stage IA high-intermediate endometrial
cancer to those women of stage IB High-intermediate endometrial
cancer.

Methods: A
single center, retrospective department database review was performed to
identify patients with endometrial Cancer. A total of 46 women with Stage
I endometrial cancer who were unequivocally LVSI positive and grade 1-2 between 2008 and 2018 were
included in this retrospective study. Seventeen (37%) were classified as Stage IA and 29 (63%)
as Stage IB. Kaplan-Meier method was used to generate survival data.

Results:
The
5-year disease-free survival (DFS) rate was 94.1% versus 82.3%(p=0.95) and 5-year overall survival (OS)
was94.1% versus 89%  (p=0.81) for stage
IA and stage IB, respectively.

Conclusion: DFS and OS rates of patients with Stage IA, grade 1-2
and LVSI positive endometrial cancer and Stage IB, grade 1-2 and LVSI positive
endometrial cancer seem to be similar. 

Anahtar Kelimeler

Endometrial cancer, LVSI, survival

Kaynakça

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