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Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome

Yıl 2020, , 106 - 112, 15.06.2020
https://doi.org/10.16948/zktipb.679178

Öz

Objective: Fetuin-B is a novel peptide hormone involves in energy metabolism, atherosclerosis and reproductive system. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with increased cardiovascular risk factors. We aimed to ascertain whether circulating fetuin-B levels were altered in women with PCOS and whether there was any association between fetuin-B and hormonal-metabolic parameters as well as carotid intima media thickness (CIMT).
Material and Methods: Eighty women with PCOS and 80 age- and BMI-matched controls without PCOS were recruited to this cross-sectional study. Circulating fetuin-B levels were measured by ELISA. Metabolic- hormonal parameters and CIMT of recruited subjects were also determined.
Results: Circulating fetuin-B levels were significantly elevated in women with PCOS compared to controls (409.54 ± 32.51 vs. 325.53 ± 26.86 ng/ml, P<0.001). PCOS subjects with insulin resistance showed significantly elevated circulating fetuin-B levels compared to those PCOS subjects without insulin resistance (416.03 ± 30.41 vs. 399.27 ± 33.56 ng/ml, P = 0.024). Overweight/obese women had significantly higher circulating fetuin-B levels than lean subjects in PCOS groups (416.32 ± 30.99 vs. 400.82 ± 32.77 ng/ml, P = 0.033). Fetuin-B levels positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free-androgen index (FAI), high sensitivity C-reactive protein (hs-CRP), triglycerides and CIMT in PCOS subjects whereas fetuin-B negatively correlated with high density lipoprotein cholesterol (HDL-C). Moreover, binary logistic regression analysis revealed that the risk of having PCOS was increased in parallel with elevation of fetuin-B levels.
Conclusion: Circulating fetuin-B levels were significantly increased in PCOS subjects and fetuin-B levels were closely related to cardiovascular risk and hormonal-metabolic disturbances in women with PCOS.

ÖZET
Amaç :Fetuin-b enerji metabolizması, ateroskleroz ve üreme sisteminde rol oynayan yeni bir peptid hormonudur.Polikistik over sendromu (PKOS) üreme ve metabolik sistemleri içeren artmış kardivasküler risk taşıyan bir hastalıktır.Bu çalışmada PKOS'lu kadınlarda dolaşımdaki Fetuin-b düzeyinde değişiklik olup olmadığını ve Fetuin-b düzeyi ile hormonal-metabolik parametreler ile Karotis intima media kalınlığı (CIMT) arasında bir ilişki olup olmadığını tespit etmeyi amaçladık.
Gereç ve Yöntemler:Kesitsel çalışmamıza 80 PKOS’lu kadın alınmıştır. Kontrol grup olarak 80 tane yaş ve BMI uyumlu kadın çalışmaya alınmıştır.Dolaşımdaki Fetuin-b seviyeleri ELISA yöntemi ile ölçüldü. Ayrıca deneklerin metabolik hormonal parametreleri ve CIMT'si de belirlenmiştir.
Bulgular:Dolaşımdaki Fetuin-b düzeyleri PKOS'lu kadınlarda kontrollere göre anlamlı derecede yüksek bulundu (409.54 ± 32.51 vs. 325.53 ± 26.86 ng/ml, P<0.001).İnsülin direncine sahip PKOS denekleri, insülin direncine sahip olmayan PCOS öznelerine göre anlamlı derecede yüksek dolaşım Fetuin-B seviyeleri gösterdi (416.03 ± 30.41 vs. 399.27 ± 33.56 ng/ml, P = 0.024).
Aşırı kilolu / obez kadınlarda PKOS gruplarında düşük kilolu deneklerden anlamlı derecede daha yüksek dolaşımdaki Fetuin-b düzeyleri vardı (416.32 ± 30.99 vs. 400.82 ± 32.77 ng/ml, P = 0.033).Fetuin-B düzeyleri BKİ, insülin direncinin homeostaz modelinin değerlendirilmesi (HOMA-IR), free-androgen index (FAI), high sensitivity C-reactive protein (hs-CRP) trigliseritler ve CIMT ile pozitif korelasyon gösterir iken yüksek yoğunluklu lipoprotein kolesterol (HDL-C) ile negatif korelasyon göstermektedir. Ayrıca ikili lojistik regresyon analizi, PKOS olma riskinin Fetuin-B seviyelerinin yükselmesine paralel olarak arttığını ortaya koydu.
Sonuç:Dolaşımdaki Fetuin-B düzeyleri PKOS'lu hastalarda anlamlı olarak artmış olup Fetuin-B düzeyleri PKOS'lu kadınlarda kardiyovasküler risk ve hormonal metabolik bozukluklarla yakından ilişkilidir.

Kaynakça

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Toplam 2 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Aslı Bayındır

Gokcen Unal

Cetin İmamoğlu

Yasemin Alan

Yayımlanma Tarihi 15 Haziran 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Bayındır, A., Unal, G., İmamoğlu, C., Alan, Y. (2020). Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome. Zeynep Kamil Tıp Bülteni, 51(2), 106-112. https://doi.org/10.16948/zktipb.679178
AMA Bayındır A, Unal G, İmamoğlu C, Alan Y. Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome. Zeynep Kamil Tıp Bülteni. Haziran 2020;51(2):106-112. doi:10.16948/zktipb.679178
Chicago Bayındır, Aslı, Gokcen Unal, Cetin İmamoğlu, ve Yasemin Alan. “Increased Fetuin-B Levels Are Associated With Carotid Intima Media Thickness and Hormonal-Metabolic Disturbances in Women With Polycystic Ovary Syndrome”. Zeynep Kamil Tıp Bülteni 51, sy. 2 (Haziran 2020): 106-12. https://doi.org/10.16948/zktipb.679178.
EndNote Bayındır A, Unal G, İmamoğlu C, Alan Y (01 Haziran 2020) Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome. Zeynep Kamil Tıp Bülteni 51 2 106–112.
IEEE A. Bayındır, G. Unal, C. İmamoğlu, ve Y. Alan, “Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome”, Zeynep Kamil Tıp Bülteni, c. 51, sy. 2, ss. 106–112, 2020, doi: 10.16948/zktipb.679178.
ISNAD Bayındır, Aslı vd. “Increased Fetuin-B Levels Are Associated With Carotid Intima Media Thickness and Hormonal-Metabolic Disturbances in Women With Polycystic Ovary Syndrome”. Zeynep Kamil Tıp Bülteni 51/2 (Haziran 2020), 106-112. https://doi.org/10.16948/zktipb.679178.
JAMA Bayındır A, Unal G, İmamoğlu C, Alan Y. Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome. Zeynep Kamil Tıp Bülteni. 2020;51:106–112.
MLA Bayındır, Aslı vd. “Increased Fetuin-B Levels Are Associated With Carotid Intima Media Thickness and Hormonal-Metabolic Disturbances in Women With Polycystic Ovary Syndrome”. Zeynep Kamil Tıp Bülteni, c. 51, sy. 2, 2020, ss. 106-12, doi:10.16948/zktipb.679178.
Vancouver Bayındır A, Unal G, İmamoğlu C, Alan Y. Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome. Zeynep Kamil Tıp Bülteni. 2020;51(2):106-12.