75 gr oral glukoz tolerans testi sağlıklı gebelerde maternal ve fetal Doppler parametrelerini etkiler mi? Kesitsel-gözlemsel bir çalışma

Öz

Amaç: Oral glukoz tolerans testi (OGTT) gestasyonel diyabet (GDM) taramasında tüm dünyada yaygın olarak kullanılmaktadır. Bu çalışmada Van Bölge Eğitim ve Araştırma hastanesine başvuran ve 75 gr OGTT yapılan ve GDM saptanmayan gebelerde testin maternal ve fetal Doppler parametrelerine etkisini inceledik. Materyel-metod: Kliniğimizde takip edilen, 24-28 gebelik haftaları arasında 75 gr OGTT uygulanan ve GDM saptanmayan 46 sağlıklı gebede OGTT’den 1 saat önce ve testin tamamlanmasından 1 saat sonra umblikal arter PI, RI, ve S/D, MCA PSV, PI, RI ve her iki uterin arterin ortalama PI, RI,S/D değerleri kaydedildi. Veriler SPSS-16 programı ve Mann Whitney-U testi kullanılarak analiz edildi ve p değeri<0.05 anlamlı kabul edildi. Bulgular: Olguların ortalama yaşı 24.6±5.4 yıl, ortalama gebelik sayısı 2.3±0.8, ortalama vücut kitle indeksi (VKİ) 25.5±5.1 kg/m2 ve ortalama gebelik haftası 26.5±1.5 bulundu. Testten 1 saat önce ortalama umblikal arter PI: 1.14±0.26, RI: 0.71±0.14 ve S/D oranı 2.24±0.73 saptandı. Testin tamamlanmasından 1 saat sonra ise ortalama umblikal arter PI: 1.04±0.43, RI: 0.58±0.21 ve S/D oranı 2.01±0.44 saptandı ve bu fark istatistiksel anlamlı değildi (p:0.64, 0,56, 0.71). Testten 1 saat önce ortalama MCA PSV 30.4±11.3 cm/sn, ortalama PI: 1.89±0.36 ve RI: 0.81±0.19 saptandı. Testin tamamlanmasından 1 saat sonra ise ortalama MCA PSV 38.4±13.2 cm/sn, ortalama PI: 2.11±0.24 ve RI: 0.68± 0.21 saptandı ve bu fark istatistiksel anlamlı değildi (p:0.83, 0.66, 0.82). Test öncesi her iki uterin arter ortalama PI:1.13±0.21, RI: 0.69±0.11 ve S/D oranı 2.03±0.34 bulundu. Test sonrası ise her iki uterin arter ortalama PI:1.24±0.11, RI: 0.74±0.16 ve S/D oranı 1.87±0.22 saptandı ve bu fark anlamlı bulunmadı (p:0.72, 0.79, 0.56). Sonuç: 75 gr OGTT normal saptanan sağlıklı kadınlarda OGTT maternal ve fetal kan akımı üzerine anlamlı etkisi bulunmamaktadır.

Anahtar Kelimeler

• Doppler,diyabet

Does 75-g oral glucose tolerance test (OGTT) influence maternal and fetal Doppler parameters in healthy pregnancies? A cross-sectional observational study

Abstract

Aim: Oral glucose challenge test (OGTT) is widely used around the world screening for gestational diabetes mellitus (GDM). In our study, we aimed to evaluate the effect of 75 g OGTT on maternal and fetal Doppler parameters. Material and Methods: Measurements of umbilical artery PI, RI, S/D, middle cerebral artery (MCA) PSV, PI, RI and mean PI, RI S/D of uterine arteries assessed 1 hour before OGTT and 1 hour following the test in 46 pregnancies between 24-28 weeks of gestation. Mann Whitney-U test was employed to compare variables. Statistical significance was established at p<0.05. Results: The mean age of pregnant women was 24.6±5.4, the mean gravity status was 2.3±0.8, the mean BMI was 25.5±5.5 kg/m, and the mean gestational age was 26.5±1.6 Mean umbilical artery PI: 1.14±0.26, RI: 0.71±0.14, S/D ratio 2.24±0.73 calculated 1 hour before test and mean PI: 1.04±0.43, RI: 0.58±0.21, S/D ratio 2.01±0.44 and there was no significance (p: 0.64, 0,56, 0.71). Mean MCA PSV: 30.4±11.3 cm/sn, PI:1.89±0.36, RI: 0.81±0.19 measured 1 hour before test and 1 hour following test Mean MCA were PSV: 38.4±13.2 cm/sn, PI: 2.11±0.24, RI: 0.68± 0.21 and there was no difference (p: 0.83, 0.66, 0.82). Mean uterine arteries PI:1.13±0.21, RI: 0.69±0.11, S/D ratio 2.03±0.34 measured before the test and mean PI:1.24±0.11, RI: 0.74±0.16, S/D ratio 1.87±0.22 calculated after the test and these results were similar (p: 0.72, 0.79, 0.56). Conclusion: There was no significant effect on maternal and fetal Doppler parameters of 75 g OGTT among healthy pregnancies.

Keywords

• Doppler,diabetes,fetus

Kaynakça

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