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Yıl 2014, Cilt: 45 Sayı: 2, 65 - 70, 11.07.2014

Ecmel Kaygusuz , Handan Çetiner Meryem Eken , Cume Yorgancı Suna Cesur Hülya Yavuz Nermin Koç

Öz

Aim: Leiomyosarcoma is a rare malign neoplasm of the uterus. The current retrospective study examined leiomyosarcoma who were evaluated at our institution over a 8 year period.Material-Method: Clinical records of the cases operated with the diagnosis of leiomyosarcoma, between January 2005 and October 2013, reviewed retrospectively. All material belonging to 22 cases were evaluated histologically.Results: There were 22 females, whose age range from 41 to 73 (median 54 years). The neoplasm measured from 1,5 to 16 cm greatest diameter ( median 8,8 cm).Conclusion: In conclusion, leiomyosarcoma is a aggressive neoplasm. The diagnosis of leiomyosarcomas depends on a combination of microscopic features. Our cases clinicopathological correlation values were parallel to the literature.

Anahtar Kelimeler

Leiomyosarcoma uterus immunohistochemistry anaplasia mitoticindexCiLT: 45 YIL : 2014 SAYI: 2ZEYNEP KAMİL TIP BÜLTENİ 2014;45:65-70KLiNiK ARAŞTIRMA

Kaynakça

  • Kurman RJ. Blaustein’s Pathology of the Female Genital Tract. In: Zaloudek C, Hendrickson MR (eds). Mesenchymal Tumors of the Uterus. 5th edition. New York: Springer-Verlag; 2002. 561-92.
  • Tavassolli FA, Devilee P, (eds). World Organization Classification of Tumors Pathology and Genetics, Tumors of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.233-42.
  • Ryan KJ, Berkowitz RS, Barbieri RL. Kistner’s Gynecology Principles and Practice. In: Muto MG, Friedman AJ (eds). The Uterine Corpus. 6th edition. St. Louis, Missouri: Mosby;1995.159-61.
  • Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasm. A clinicopathologic study of 213 cases. Am J Surg Pathol.1994;18:535-538.
  • Van Dinh T, Woodruff JO: Leiomyosarcoma of the uterus. Am J Obstet Gynecol 1982, 144:817-823
  • Hendrickson MR, Kempson RL: Surgical Pathology of the Uterine Corpus, in Bennington JL(ed): Major problems in Patholgy. Philadelphia, Saunders,1980 Vol12,468-529.
  • Mayerhofer K, Obermair A, Windbichler G, et al. Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol. 1999;74:196-201.
  • Wang WL, Soslow R, Hensley M, Asad H et al. Histopathologic prognostic factors in stage 1 leiomyosarcoma of the uterus: adetailed analysis of 27 cases. Am J Surg Pathol. 2011, 35:522-529
  • Lusby K, Savannah KB, Demicco EG et al. Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience. Ann Surg Oncol (2013),20:2364-2372
  • Barter JF, Smith EB, Szpak CA: Leiomyosarcoma of the uterus: a clinicopathologic study of 21 cases. Gynecol Oncol 1985,21:220-227
  • Schwartz Z, Dgani R, Lancet M,: Uterine sarcoma in Israel: a sudy of 104 cases. Gynecol Oncol 1985, 20:354-363
  • Evans HL, Chawla Sp, Simpson C: Smooth muscle neoplasm of the uterus other than ordinary leiomyoma: A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988,62:2239-2247.
  • Bazzocchi F, Brandi G, Pileri S: Clinical and prognostic features of leiomyosarcoma of the uterus. Tumori 1983,69:75-77.
  • Rauh-Hain JA, Oduyebo T, Diver EJ. Uterine Leiomyosarcoma, an update series. Int J of Gynecol Can. 2013;23:1036-1043.

Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases)

Yıl 2014, Cilt: 45 Sayı: 2, 65 - 70, 11.07.2014

Ecmel Kaygusuz , Handan Çetiner Meryem Eken , Cume Yorgancı Suna Cesur Hülya Yavuz Nermin Koç

Öz

Amaç: Leiomyosarkom uterusun nadir görülen malign bir tümörüdür. Bu retrospektif çalışmada 8 yıllık periotta bölümümüzde değerlendirilmiş leiomyosarkom tanısı almış olgular çalışılmıştır.

Materyal-Metod: Ocak 2005 ile  Ekim 2013 tarihleri arasında leiomyosarkom tanısı ile opere edilen olguların tüm hastane kayıtları geriye yönelik olarak değerlendirildi. 22 hastaya ait tüm materyeller histolojik olarak değerlendirildi.

Bulgular: Yaşları 41 ile 73 arasında değişen (ortalama 54) 22 kadın hasta değerlendirildi. Tümörlerin en geniş çapları 1,5 ile 16 cm arasında değişiyordu (ortalama 8,8).

Sonuç: Leiomyosarkom agresif bir neoplazmdır. Leiomyosarkomların tanısı kombine mikroskopik bulgulara dayanmaktadır. Bizim olgularımızın klinikopatolojik verileri literatür verilerine paralellik göstermekteydi.

Anahtar Kelimeler: leiomyosarkom, uterus, immunohistokimya, anaplazi, mitotik endeks.

Abstract

Aim: Leiomyosarcoma is a rare malign neoplasm of the uterus. The current retrospective study examined leiomyosarcoma who were evaluated at our institution over a  8 year period.

Material-Method: Clinical records of the cases operated with the diagnosis of leiomyosarcoma, between January 2005 and October 2013, reviewed retrospectively. All material belonging to 22 cases were evaluated histologically.

Results: There were  22 females, whose age range from 41 to 73 (median 54 years). The neoplasm measured from 1,5 to 16 cm greatest diamater ( median 8,8 cm).

Conclusion: In conclusion, leiomyosarcoma is a aggressive neoplasm. The diagnosis of leiomyosarcomas depends on a combination of microscopic features. Our  cases  clinicopathological correlation values were parallel to the literature.

Keywords: Leiomyosarcoma, uterus, immunohistochemistry,  anaplasia, mitotic index

Anahtar Kelimeler

leiomyosarkom uterus immunohistokimya anaplazi mitotik endeks.

Kaynakça

  • Kurman RJ. Blaustein’s Pathology of the Female Genital Tract. In: Zaloudek C, Hendrickson MR (eds). Mesenchymal Tumors of the Uterus. 5th edition. New York: Springer-Verlag; 2002. 561-92.
  • Tavassolli FA, Devilee P, (eds). World Organization Classification of Tumors Pathology and Genetics, Tumors of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.233-42.
  • Ryan KJ, Berkowitz RS, Barbieri RL. Kistner’s Gynecology Principles and Practice. In: Muto MG, Friedman AJ (eds). The Uterine Corpus. 6th edition. St. Louis, Missouri: Mosby;1995.159-61.
  • Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasm. A clinicopathologic study of 213 cases. Am J Surg Pathol.1994;18:535-538.
  • Van Dinh T, Woodruff JO: Leiomyosarcoma of the uterus. Am J Obstet Gynecol 1982, 144:817-823
  • Hendrickson MR, Kempson RL: Surgical Pathology of the Uterine Corpus, in Bennington JL(ed): Major problems in Patholgy. Philadelphia, Saunders,1980 Vol12,468-529.
  • Mayerhofer K, Obermair A, Windbichler G, et al. Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol. 1999;74:196-201.
  • Wang WL, Soslow R, Hensley M, Asad H et al. Histopathologic prognostic factors in stage 1 leiomyosarcoma of the uterus: adetailed analysis of 27 cases. Am J Surg Pathol. 2011, 35:522-529
  • Lusby K, Savannah KB, Demicco EG et al. Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience. Ann Surg Oncol (2013),20:2364-2372
  • Barter JF, Smith EB, Szpak CA: Leiomyosarcoma of the uterus: a clinicopathologic study of 21 cases. Gynecol Oncol 1985,21:220-227
  • Schwartz Z, Dgani R, Lancet M,: Uterine sarcoma in Israel: a sudy of 104 cases. Gynecol Oncol 1985, 20:354-363
  • Evans HL, Chawla Sp, Simpson C: Smooth muscle neoplasm of the uterus other than ordinary leiomyoma: A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988,62:2239-2247.
  • Bazzocchi F, Brandi G, Pileri S: Clinical and prognostic features of leiomyosarcoma of the uterus. Tumori 1983,69:75-77.
  • Rauh-Hain JA, Oduyebo T, Diver EJ. Uterine Leiomyosarcoma, an update series. Int J of Gynecol Can. 2013;23:1036-1043.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Cover Pages
Yazarlar

Ecmel Kaygusuz

Handan Çetiner Bu kişi benim

Meryem Eken

Cume Yorgancı Bu kişi benim

Suna Cesur Bu kişi benim

Hülya Yavuz Bu kişi benim

Nermin Koç Bu kişi benim

Yayımlanma Tarihi 11 Temmuz 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 45 Sayı: 2

Kaynak Göster

APA Kaygusuz, E., Çetiner, H., Eken, M., Yorgancı, C., vd. (2014). Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases). Zeynep Kamil Tıp Bülteni, 45(2), 65-70. https://doi.org/10.16948/zktb.20328
AMA Kaygusuz E, Çetiner H, Eken M, Yorgancı C, Cesur S, Yavuz H, Koç N. Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases). Zeynep Kamil Tıp Bülteni. Temmuz 2014;45(2):65-70. doi:10.16948/zktb.20328
Chicago Kaygusuz, Ecmel, Handan Çetiner, Meryem Eken, Cume Yorgancı, Suna Cesur, Hülya Yavuz, ve Nermin Koç. “Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic Evaluation of 22 Cases)”. Zeynep Kamil Tıp Bülteni 45, sy. 2 (Temmuz 2014): 65-70. https://doi.org/10.16948/zktb.20328.
EndNote Kaygusuz E, Çetiner H, Eken M, Yorgancı C, Cesur S, Yavuz H, Koç N (01 Temmuz 2014) Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases). Zeynep Kamil Tıp Bülteni 45 2 65–70.
IEEE E. Kaygusuz, H. Çetiner, M. Eken, C. Yorgancı, S. Cesur, H. Yavuz, ve N. Koç, “Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases)”, Zeynep Kamil Tıp Bülteni, c. 45, sy. 2, ss. 65–70, 2014, doi: 10.16948/zktb.20328.
ISNAD Kaygusuz, Ecmel vd. “Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic Evaluation of 22 Cases)”. Zeynep Kamil Tıp Bülteni 45/2 (Temmuz 2014), 65-70. https://doi.org/10.16948/zktb.20328.
JAMA Kaygusuz E, Çetiner H, Eken M, Yorgancı C, Cesur S, Yavuz H, Koç N. Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases). Zeynep Kamil Tıp Bülteni. 2014;45:65–70.
MLA Kaygusuz, Ecmel vd. “Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic Evaluation of 22 Cases)”. Zeynep Kamil Tıp Bülteni, c. 45, sy. 2, 2014, ss. 65-70, doi:10.16948/zktb.20328.
Vancouver Kaygusuz E, Çetiner H, Eken M, Yorgancı C, Cesur S, Yavuz H, Koç N. Uteri̇n Lei̇omyosarkom: 22 Olguda Patolojik Değerlendirme (Uterine Leiomyosarcoma: Pathologic evaluation of 22 Cases). Zeynep Kamil Tıp Bülteni. 2014;45(2):65-70.
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