Preeklampside androgen seviyeleri yüksek mi?

Yıl 2003, Cilt: 34 Sayı: 2, 25 - 29, 01.03.2003

Gülseren Yücesoy Hale Maral Meltem Özden İzzet Yücesoy Aydın Çorakçı Semih Özeren

Öz

Objective: To investigate the androgen levels in preeclamptic pregnancies compared to normotensive cases. Material-methods: Fifty-eight primigravid women with singleton pregnancies were admitted to the study. Thirty cases were diagnosed as preeclampsia and these patients were considered as the study group. The control group consisted of 28 normotensive patients. Maternal venous blood samples were collected. Serum estradiol, total testosterone, sex hormone binding globulin and dehydroepiandrosterone sulfate levels were measured. The GraphPad Instat PC program was used, and the student t-test was performed. Results: There was no statistically significant difference between the control and the study group with respect to maternal age, gestational age and body mas s index. Furthermore, there was no statistically significant difference between the two groups regarding to serum estradiol, total testosterone, sex hormone binding globulin, and dehydroepiandrosterone sulfate levels (p>0.05). Conclusion: This study indicated that there is no difference in androgen hormone levels between the normotensive and the pre e clamptic pregnancie s.

Anahtar Kelimeler

Pregnancy Complications, Pre-Eclampsia, Androgens, Testosterone, Pregnancy Toxemias

Are androgen levels high in preeclampsia

Öz

Amaç: Çalışmanın amacı, preeklamptik gebelerde androjen hormon seviyelerini, tansiyonu normal olan gebeler ile karşılaşnrarak araştırmak. Mateıyalve metod: 58 primigravid teka gebelik olgusu çalışmaya alındı. Preeklampsi tanısı konulan 30 olgu çalışma grubunu oluşturdu. Tansiyonu normal olan 28 gebe ise kontrol grubu olarak alındı. Matemal venöz kanda, serum östradiol, total testosteron, seks hormon bağlayıcı globulin ve dehidroepiandrosteron sülfat seviyelerine bakıldı. GraphPad Instat PC programı kullanıldı, student t-testi uygulandı. Bulgular : Çalışma ve kontrol grubunun maternal yaşı, gebelik haftası ve vücut kütle indeksinde istatistiksel anlamlı farklılık saptanmadı. Her iki grup arasında, serum östradiol, total testosteron, seks hormon bağlayıcı globulin ve dehidroepiandrosteron sülfat düzeylerinde istatistiksel anlamlı farklılık bulunmadı(p >0.05). Sonuç: Preeklamptik gebelerde, serum androjen hormon seviyelerinin, tansiyonu normal gebeler ile farklılık oluşturmadığı sonucuna varıldı.

Anahtar Kelimeler

Gebelik komplikasyonları, Preeklampsi, Androjenler, Testosteron, Gebelik toksemisi

Kaynakça

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