Öz
Objective: To evaluate MIB-1 expression in cellular leiomyomas and leiomyos arcomas. Materials and Methods:The study includes 17 patients with cellular leiomyomas and 7 patients with leiomyosarcoma diagnosed between 1997 and 2003 at the Pathology Laboratory of Zeynep Kamil Hospital. Tumor representative one paraffin embedded tissue from each case was evaluated immunohistochemicaUy for MIB-1. Results :While all 7 cases of leiomyosarcoma revealed 15% and more MIB-1 expression there was no MIB-1 expression of?% 15 in any of cellular leiomyomas. There was less than 5% and weak expression in one case of cellular leiomyoma. Conclusion: MIB-1 expression could be used in contradictory cases as an ancillary method along with conventional diagnostic parameters.
Anahtar Kelimeler
Kaynakça
- 1. Hendrickson MR, Kempson RL. Pure mesenchymal neoplasms of the uterine corpus. In; FoxH, Wells M. Eds. Obstetrical and Gynecological Pathology. Vol 1. 5th edn. Edinburg, London ; Churchill Livingstone; 2003 : 497-548
- 2. Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors. Histopathology 1996; 29: 217-23
- 3. Amada S, Nakamo H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p 53 expression, DNA flow cytometry, and muscle specific actihs. Int J Gynecol Pathol 1995; 14: 134-42
- 4. Zhai YL, Kobayashi Y, Mori A etal. Expression of steroid receptors, Ki-67 and p 53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999; 18: 20-8
- 5. Mittal K, Demopoulos RL MIB-1 (Ki-67), p 53, estrogen receptor and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001; 32: 984-7
- 6. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos RI. MIB-1 as a possible predictor of recurrence in low-grade endometrial sarcoma of the uterus. Gynecol Oncol 2003; 2: 353-7
- 7. Yavuz E, Güllüoglu MG, Akbaş N. et al. The values of intrdtumoral mast cell count and Ki- 67 immunre activityindex in differential diagnosis of uterine smooth muscle neoplasms. PatholInt 2001; 51: 938-41: 8. Jejfers MD, Oakes SJ, Richmond J A, et al. Proliferation, ploidy and prognosis in uterine smooth muscle tumors. Histopathology 1996; 29: 217-23
- 9. Zhai YL, Nikaido T, Shiozowa T et al. Expression ofcyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. IntJ Cancer 1999; 84: 224-50
- 10. Sprogel-Jakobsen S, Halund B. Immunohistochemistry (Ki-67 and p 53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). Ada Pathol Microbiol Immunol Scand 1996; 104: 705-8.
Öz
Amaç: Selüler leiomyom ve leimyvsarkomların MIB-1 ekspresyonlarını değerlendirmek. Materyal ve Method: 1997-2003 yıllan arasında Zeynep Kamil Hastanesi Patoloji Bölümünde tanı almış 17 selüler leiomyom ve 7 leiomyo sarkom olgusu çalışma kapsamına alındı. Tümörleri temsil eden birer parafin blokda immıınhis to kimyasal yöntemle MIB-1 boyanması incelendi. Bulgular: Yedi adet leiomyosarkom olgusunun tümünde % 15 ve üzerinde MIB-1 ekspresyonu saptanırken, 17 adet sekiler leiomyom olgusunun hiçbirinde bu oranın üzerinde ekspresyon izlenmedi. Bir adet sekiler leiomyom olgusunda % 5 den az ve zayıf MIB-1 ekspresyonu kaydedildi. Sonuç: Çelişkili olgularda selüler leiomyomları, leiomyosarkomdam ayırmak için, MIB-1 ekspresyonunu bilinen parametrelere yardımcı bir yöntem olarak kullanabiliriz.
Anahtar Kelimeler
Kaynakça
- 1. Hendrickson MR, Kempson RL. Pure mesenchymal neoplasms of the uterine corpus. In; FoxH, Wells M. Eds. Obstetrical and Gynecological Pathology. Vol 1. 5th edn. Edinburg, London ; Churchill Livingstone; 2003 : 497-548
- 2. Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors. Histopathology 1996; 29: 217-23
- 3. Amada S, Nakamo H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p 53 expression, DNA flow cytometry, and muscle specific actihs. Int J Gynecol Pathol 1995; 14: 134-42
- 4. Zhai YL, Kobayashi Y, Mori A etal. Expression of steroid receptors, Ki-67 and p 53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999; 18: 20-8
- 5. Mittal K, Demopoulos RL MIB-1 (Ki-67), p 53, estrogen receptor and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001; 32: 984-7
- 6. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos RI. MIB-1 as a possible predictor of recurrence in low-grade endometrial sarcoma of the uterus. Gynecol Oncol 2003; 2: 353-7
- 7. Yavuz E, Güllüoglu MG, Akbaş N. et al. The values of intrdtumoral mast cell count and Ki- 67 immunre activityindex in differential diagnosis of uterine smooth muscle neoplasms. PatholInt 2001; 51: 938-41: 8. Jejfers MD, Oakes SJ, Richmond J A, et al. Proliferation, ploidy and prognosis in uterine smooth muscle tumors. Histopathology 1996; 29: 217-23
- 9. Zhai YL, Nikaido T, Shiozowa T et al. Expression ofcyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. IntJ Cancer 1999; 84: 224-50
- 10. Sprogel-Jakobsen S, Halund B. Immunohistochemistry (Ki-67 and p 53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). Ada Pathol Microbiol Immunol Scand 1996; 104: 705-8.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Şubat 2004 |
| Yayımlandığı Sayı | Yıl 2004 Cilt: 35 Sayı: 1 |