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Yıl 2004, Cilt 35, Sayı 1, 1 - 3, 01.02.2004

Öz

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Kaynakça

  • 1. Hendrickson MR, Kempson RL. Pure mesenchymal neoplasms of the uterine corpus. In; FoxH, Wells M. Eds. Obstetrical and Gynecological Pathology. Vol 1. 5th edn. Edinburg, London ; Churchill Livingstone; 2003 : 497-548
  • 2. Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 3. Amada S, Nakamo H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p 53 expression, DNA flow cytometry, and muscle specific actihs. Int J Gynecol Pathol 1995; 14: 134-42
  • 4. Zhai YL, Kobayashi Y, Mori A etal. Expression of steroid receptors, Ki-67 and p 53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999; 18: 20-8
  • 5. Mittal K, Demopoulos RL MIB-1 (Ki-67), p 53, estrogen receptor and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001; 32: 984-7
  • 6. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos RI. MIB-1 as a possible predictor of recurrence in low-grade endometrial sarcoma of the uterus. Gynecol Oncol 2003; 2: 353-7
  • 7. Yavuz E, Güllüoglu MG, Akbaş N. et al. The values of intrdtumoral mast cell count and Ki- 67 immunre activityindex in differential diagnosis of uterine smooth muscle neoplasms. PatholInt 2001; 51: 938-41: 8. Jejfers MD, Oakes SJ, Richmond J A, et al. Proliferation, ploidy and prognosis in uterine smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 9. Zhai YL, Nikaido T, Shiozowa T et al. Expression ofcyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. IntJ Cancer 1999; 84: 224-50
  • 10. Sprogel-Jakobsen S, Halund B. Immunohistochemistry (Ki-67 and p 53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). Ada Pathol Microbiol Immunol Scand 1996; 104: 705-8.

MIB-1 expression in cellular leiomyomas and leiomyosarcomas

Yıl 2004, Cilt 35, Sayı 1, 1 - 3, 01.02.2004

Öz

Objective: To evaluate MIB-1 expression in cellular leiomyomas and leiomyos arcomas. Materials and Methods:The study includes 17 patients with cellular leiomyomas and 7 patients with leiomyosarcoma diagnosed between 1997 and 2003 at the Pathology Laboratory of Zeynep Kamil Hospital. Tumor representative one paraffin embedded tissue from each case was evaluated immunohistochemicaUy for MIB-1. Results :While all 7 cases of leiomyosarcoma revealed 15% and more MIB-1 expression there was no MIB-1 expression of?% 15 in any of cellular leiomyomas. There was less than 5% and weak expression in one case of cellular leiomyoma. Conclusion: MIB-1 expression could be used in contradictory cases as an ancillary method along with conventional diagnostic parameters.

Kaynakça

  • 1. Hendrickson MR, Kempson RL. Pure mesenchymal neoplasms of the uterine corpus. In; FoxH, Wells M. Eds. Obstetrical and Gynecological Pathology. Vol 1. 5th edn. Edinburg, London ; Churchill Livingstone; 2003 : 497-548
  • 2. Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 3. Amada S, Nakamo H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p 53 expression, DNA flow cytometry, and muscle specific actihs. Int J Gynecol Pathol 1995; 14: 134-42
  • 4. Zhai YL, Kobayashi Y, Mori A etal. Expression of steroid receptors, Ki-67 and p 53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999; 18: 20-8
  • 5. Mittal K, Demopoulos RL MIB-1 (Ki-67), p 53, estrogen receptor and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001; 32: 984-7
  • 6. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos RI. MIB-1 as a possible predictor of recurrence in low-grade endometrial sarcoma of the uterus. Gynecol Oncol 2003; 2: 353-7
  • 7. Yavuz E, Güllüoglu MG, Akbaş N. et al. The values of intrdtumoral mast cell count and Ki- 67 immunre activityindex in differential diagnosis of uterine smooth muscle neoplasms. PatholInt 2001; 51: 938-41: 8. Jejfers MD, Oakes SJ, Richmond J A, et al. Proliferation, ploidy and prognosis in uterine smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 9. Zhai YL, Nikaido T, Shiozowa T et al. Expression ofcyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. IntJ Cancer 1999; 84: 224-50
  • 10. Sprogel-Jakobsen S, Halund B. Immunohistochemistry (Ki-67 and p 53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). Ada Pathol Microbiol Immunol Scand 1996; 104: 705-8.

Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu

Yıl 2004, Cilt 35, Sayı 1, 1 - 3, 01.02.2004

Öz

Amaç: Selüler leiomyom ve leimyvsarkomların MIB-1 ekspresyonlarını değerlendirmek. Materyal ve Method: 1997-2003 yıllan arasında Zeynep Kamil Hastanesi Patoloji Bölümünde tanı almış 17 selüler leiomyom ve 7 leiomyo sarkom olgusu çalışma kapsamına alındı. Tümörleri temsil eden birer parafin blokda immıınhis to kimyasal yöntemle MIB-1 boyanması incelendi. Bulgular: Yedi adet leiomyosarkom olgusunun tümünde % 15 ve üzerinde MIB-1 ekspresyonu saptanırken, 17 adet sekiler leiomyom olgusunun hiçbirinde bu oranın üzerinde ekspresyon izlenmedi. Bir adet sekiler leiomyom olgusunda % 5 den az ve zayıf MIB-1 ekspresyonu kaydedildi. Sonuç: Çelişkili olgularda selüler leiomyomları, leiomyosarkomdam ayırmak için, MIB-1 ekspresyonunu bilinen parametrelere yardımcı bir yöntem olarak kullanabiliriz.

Kaynakça

  • 1. Hendrickson MR, Kempson RL. Pure mesenchymal neoplasms of the uterine corpus. In; FoxH, Wells M. Eds. Obstetrical and Gynecological Pathology. Vol 1. 5th edn. Edinburg, London ; Churchill Livingstone; 2003 : 497-548
  • 2. Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 3. Amada S, Nakamo H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p 53 expression, DNA flow cytometry, and muscle specific actihs. Int J Gynecol Pathol 1995; 14: 134-42
  • 4. Zhai YL, Kobayashi Y, Mori A etal. Expression of steroid receptors, Ki-67 and p 53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999; 18: 20-8
  • 5. Mittal K, Demopoulos RL MIB-1 (Ki-67), p 53, estrogen receptor and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001; 32: 984-7
  • 6. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos RI. MIB-1 as a possible predictor of recurrence in low-grade endometrial sarcoma of the uterus. Gynecol Oncol 2003; 2: 353-7
  • 7. Yavuz E, Güllüoglu MG, Akbaş N. et al. The values of intrdtumoral mast cell count and Ki- 67 immunre activityindex in differential diagnosis of uterine smooth muscle neoplasms. PatholInt 2001; 51: 938-41: 8. Jejfers MD, Oakes SJ, Richmond J A, et al. Proliferation, ploidy and prognosis in uterine smooth muscle tumors. Histopathology 1996; 29: 217-23
  • 9. Zhai YL, Nikaido T, Shiozowa T et al. Expression ofcyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. IntJ Cancer 1999; 84: 224-50
  • 10. Sprogel-Jakobsen S, Halund B. Immunohistochemistry (Ki-67 and p 53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). Ada Pathol Microbiol Immunol Scand 1996; 104: 705-8.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Gözde KIR Bu kişi benim


Handan ÇETİNER Bu kişi benim

Yayımlanma Tarihi 1 Şubat 2004
Yayınlandığı Sayı Yıl 2004, Cilt 35, Sayı 1

Kaynak Göster

Bibtex @ { zktipb236779, journal = {Zeynep Kamil Tıp Bülteni}, issn = {1300-7971}, eissn = {2148-4864}, address = {}, publisher = {Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH}, year = {2004}, volume = {35}, pages = {1 - 3}, doi = {10.16948/zktb.06576}, title = {Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu}, key = {cite}, author = {Kır, Gözde and Çetiner, Handan} }
APA Kır, G. & Çetiner, H. (2004). Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu . Zeynep Kamil Tıp Bülteni , 35 (1) , 1-3 . Retrieved from https://dergipark.org.tr/tr/pub/zktipb/issue/22051/236779
MLA Kır, G. , Çetiner, H. "Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu" . Zeynep Kamil Tıp Bülteni 35 (2004 ): 1-3 <https://dergipark.org.tr/tr/pub/zktipb/issue/22051/236779>
Chicago Kır, G. , Çetiner, H. "Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu". Zeynep Kamil Tıp Bülteni 35 (2004 ): 1-3
RIS TY - JOUR T1 - Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu AU - Gözde Kır , Handan Çetiner Y1 - 2004 PY - 2004 N1 - DO - T2 - Zeynep Kamil Tıp Bülteni JF - Journal JO - JOR SP - 1 EP - 3 VL - 35 IS - 1 SN - 1300-7971-2148-4864 M3 - UR - Y2 - 2021 ER -
EndNote %0 Zeynep Kamil Tıp Bülteni Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu %A Gözde Kır , Handan Çetiner %T Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu %D 2004 %J Zeynep Kamil Tıp Bülteni %P 1300-7971-2148-4864 %V 35 %N 1 %R %U
ISNAD Kır, Gözde , Çetiner, Handan . "Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu". Zeynep Kamil Tıp Bülteni 35 / 1 (Şubat 2004): 1-3 .
AMA Kır G. , Çetiner H. Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu. Zeynep Kamil Tıp Bülteni. 2004; 35(1): 1-3.
Vancouver Kır G. , Çetiner H. Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu. Zeynep Kamil Tıp Bülteni. 2004; 35(1): 1-3.
IEEE G. Kır ve H. Çetiner , "Selüler leiomyom ve leiomyosarkomlarda MIB-1 ekspresyonu", Zeynep Kamil Tıp Bülteni, c. 35, sayı. 1, ss. 1-3, Şub. 2004, doi:10.16948/zktb.06576