Significance of CRP in pediatric Hodgkin disease aim: To determine usage of CRP in Hodgkin disease as a prognostic and diagnostic parameter

Yıl 2005, Cilt: 36 Sayı: 3, 139 - 141, 01.04.2005

Gülnur Tokuç Sedat Öktem Şihmir Şimşek Serdar Yılmaz

Öz

Materials and Methods: We evaluated the relationship of CRP, with disease stage, presence of B symptom and prognosis in our 20 patients with the diagnosis of Hodgkin disease retrospectively. Results: CRP was high in 10 (50 %) of our cases. None of the patients with the disease stage I, had high CRP. CRP values were above 5 mg/L in 37 %, 83 %, 67 % of the patients stages II, III and IV respectively. It was determined that elevated CRP values and the presence of B symptoms correlated statistically. Three of the cases showed progression and received second line treatment. In all of the cases with progressive disease, CRP values were elevated at the first diagnose. Conclusion: CRP can be a useful marker at diagnosis and follow up of pediatric Hodgkin disease.

Anahtar Kelimeler

Prognosis, C-Reactive Protein, Hodgkin Disease, Retrospective Studies, Child, Biological Markers

Pediatrik Hodgkin hastalığı'nda CRP'nin önemi

Öz

Amaç: CRP'nin pediatrik Hodgkin hastalığında prognostik ve tanısal bir parametre olarak kullanılabilirliliğini değerlendirmek. Gereç ve Yöntem: 20 Hodgkin olgumuzda tanı sırasındaki CRP değerleri ile hastalığın evresi, B semptomlarının varlığı ve prognozu arasındaki ilişkiyi retrospektif olarak irdeledik. Bulgular: Olgularımızdan 10'unda (% 50) CRP'nin yüksek olduğu saptandı. Evre I'de hiçbir hastada CRP yüksek değildi. Evre II'de ise hastaların % 37'inde, evre III'de % 83'ünde, evre IV'de % 67'sinde CRP değeri 5 mg/L'nin üzerinde idi. İstatistiksel olarak irdelendiğinde CRP yüksekliğinin ileri evre ve B septomlarının varlığı ile paralellik gösterdiği görüldü. Olgularımızın 3'ü progrese olmuşlar ve ikinci seçim tedaviye alınmışlardır. Progrese olguların tamamında tanı sırasında CRP yüksek olarak bulunmuştur. Sonuç: CRP çocukluk çağı Hodgkin hastalığında tanı ve izlemde bir biyomarker olarak yararlı olabilir.

Anahtar Kelimeler

Seyir, C-reaktif protein, Hodgkin hastalığı, Geriyedönük çalışma, Çocuk, Biyolojik belirteçler

Kaynakça

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