Serum Beta hCG artış hızı gebeliğin ilk 8 haftasında sabit değil ve ikiz gebeler ile tekiz gebeliklerde farklıdır

Yıl 2006, Cilt 37, Sayı 2, 29 - 32, 01.03.2006

Ulun ULUĞ Esra Aksoy JOZWIAK Süleyman TOSUN Mustafa BAHÇECİ

Öz

Aim: To compare the increasement rate of serum fihCG levels during the first 8 weeks of gestation in singleton and twin pregnancies Materials and Methods: This study prospecüvely assessed serum fihCG levels in 155 singelton and 105 twin gestations conceived by ICSI-ET. Three consecutive blood samples were drawn on days 12,30 and 45 following ET. Lineer regression lines were plotted and the slope of the lines were compared for the rate of fihCG increase Results: Both groups were comparable in terms of maternal age and BML In both stages (days 12-30 and 30-45), the rate of _hCG increase in twin gestations was significantly higher than singletons. In addition, in all gestation groups, the rate is significantly lower in stage 2 compared to stage 1. Conclusion: fihCG secretion increasement during the first 8 weeks of gestation is not constant and gradually decreased in advanced stages, thus this rate is more pronounced in twins compared to singletons.

Anahtar Kelimeler

Chorionic Gonadotropin, beta Subunit, Human, Prospective Studies, Pregnancy, Multiple, Twins, Pregnancy, Pregnancy Trimester, First

The rate of increase in serum Beta hCG levels during the first 8 weeks of gestational life is not constatnt and different between singletons and twins

Öz

Serum fihCG Artış Hızı Gebeliğin İlk 8 Haftasında Sabit Değil Ve İkiz Gebeler İle Tekiz Gebeliklerde Farklıdır. Amaç: Serum fthCG değerindeki artış hızının gebeliğin ilk 8 haftasında değerlendirmek ve ikiz gebeler ile karşılaştırmak Materyal ve Metodlan Bu çalışma prospektif olarak ICSI-ET sonrası elde edilmiş 155 tekiz ve 105 ikiz gebede serum hcg değerlerini incelemiştir. Ardışık olarak her gebeden ET sonrası 12., 30. ve 45. günler serum fihCG seviyeleri saptanmış ve logaritmik olarak lineer regresyon analizi ile doğrular elde edilmiştir. Doğruların eğimi artış hızı olarak düşünülmüş ve farklar karşılaştırılmıştır. Bulgular: Her iki grup maternal yaş ve VKİ olarak benzerlikler göstermektedir. Her iki evrede de (12-30 günler ve 30-45 günler), ikiz gebelerdeki artış hızı tekizlere gore daha fazla saptanmıştır. Tüm gruplarda fihCG artış hızı ikinci evrede daha az olarak bulunmuştur. Sonuç: Gebeliğin ilk 8 haftasında fthCG sekresyon hızı sabit olmamakta ve ikiz gebelerde artış hızı tekiz gebelere gore daha fazla saptanmaktadır.

Anahtar Kelimeler

Korionik gonadotropin, beta subunit, insan, İleriye dönük çalışma, Gebelik, çoğul, İkizler, Gebelik, Gebelik trimester, birinci

Kaynakça

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