The comparison of amnisure ™ and altest ™ in the detection of the premature rupture of membranes

Yıl 2009, Cilt: 40 Sayı: 4, 173 - 178, 01.05.2009

Gazi Yıldırım Rukset Attar Cem Fıçıcıoğlu Ateş Karateke Narter Yeşildağlar

Öz

Objectives: Amnisure™ (based on the existense of PAMG-1 in vaginal fluid) and Altest™ (based on the nitrasin test) were compared to detect a reliable, sensitive and quick test for the detection of the premature rupture of membranes in pregnancy. Material and Methods: Fifty pregnant patients between 21-38 weeks who has a suspicion for the fluid leakage were enrolled to the study. Altest™ and then Amnisure™ were applied. A sterile speculum examination and pooling were evaluated for the positive results. Amniotic volumes were calculatedfour quadrent with obstetric ultrasound. Results: The sensitivity and spesifisity for Altest™ were 83.3% and 65.9% respectively. Altest™ had 25% truepositivity and 75% false positivity rate. However, Altest™ had 96.7% true negativity and %0.3 false negativity rates. The sensitivity and spesifisity for Amnisure™ were 83.4% and 97.8% respectively. Amnisure™ had 83% true positivity and 0.2% false positivity rate. However, Amnisure™ had 97.7% true negativity and %0.2 false negativity rates. Conclusions: Amnisure™ is more reliable in the detection of the premature rupture of membranes in pregnancy.

Anahtar Kelimeler

Fetal Membranes, Premature Rupture, Comparative Study, Pregnancy Complications, Sensitivity and Specificity

Erken membran rüptürü tanısında altest ™ ve amnisure™ adlı tanı kitlerinin karşılaştınlması

Öz

Amaçlar: EMR şüphesi olan vakalarda hızlı, güvenilir bir metot saptayabilmek için; vajinal sıvıdaki PAMG-1 tayinine dayanan Amnisure™ kiti ile nitrazin testi esasına dayanan Altest™ kiti karşılaştırılmıştır. Gereç ve Yöntem: Çalışmaya kadın doğum bölümüne su gelmesi şüphesi ile başvuran 21-38 hafta arasındaki 50 gebe dahil edildi. Hastalara önce Altest™ kiti verildi.. Sonra hasta muayene masasına yatırılarak spekulum uygulamaksızın Amnisure™ testi uygulandı. Sonuçları pozitif olanlara spekulum uygulanarak pooling değerlendirildi. Her hastanın amniyotik sıvı volumleri dört kadran ölçülerek kaydedildi. Bulgular: Altest™ in sensitivitesi %83.3, spesifısitesi %65.9 olarak hesaplandı. Altest™ in gerçek pozitiflik oranı %25, yalancı pozitiflik oranı ise %75 idi. Buna karşın Altest™ in gerçek negatiflik oranı %96.7, yalancı negatiflik oranı ise %0.3 olarak bulundu. Amnisure™ sensitivitesi %83.4, spesifısitesi %97.8 olarak hesaplandı. Amnisure™'un gerçek pozitiflik oranı %83, yalancı pozitiflik oranı ise %0.2 idi. Buna karşın Amnisure™'un gerçek negatiflik oranı %97.7, yalancı negatiflik oranı ise %0.2 olarak bulundu. Sonuçlar: Amnisure™ kiti erken membran rüptürü tanısında daha güvenilirdir.

Anahtar Kelimeler

Fetal membranlar, prematür rüptür, Karşılaştırmalı çalışma, Gebelik komplikasyonları, Duyarlılık ve özgüllük

Kaynakça

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