Psikobiyotiklerin Beslenmedeki Yeri: Yeni Bir Fonksiyonel Besin Çağı

Abstract

Psikobiyotikler, bağırsak mikrobiyotasını etkileyerek ruh sağlığını destekleme potansiyeline sahip olan yeni nesil fonksiyonel besin bileşenleridir. Bağırsak-beyin ekseni üzerinden etki gösteren bu bileşenler, depresyon, anksiyete, stres gibi psikiyatrik tabloların yönetiminde tamamlayıcı bir yaklaşım olarak değerlendirilmektedir. Psikobiyotiklerin yanı sıra, postbiyotikler ve parabiyotikler gibi mikrobiyal kökenli diğer biyotik bileşenler de son yıllarda dikkat çekmektedir. Bu bileşenler, canlı olmayan mikrobiyal ürünler veya inaktive edilmiş mikroorganizmalar olmalarına rağmen, bağışıklık fonksiyonlarını destekleme, inflamasyonu azaltma ve bağırsak bariyerini güçlendirme gibi etkiler sunmaktadır. Bu derlemede, psikobiyotik kavramı detaylı bir şekilde ele alınmış; postbiyotik ve parabiyotiklerle birlikte sağlık üzerindeki etkileri güncel literatür ışığında değerlendirilmiştir. Mikrobiyal metabolitlerin sinir sistemi ile etkileşimi, fonksiyonel besin tanımı çerçevesinde incelenmiş ve bu bileşenlerin potansiyel terapötik rolleri tartışılmıştır. Ayrıca, psikobiyotiklerin depresyon, anksiyete ve diğer ruhsal bozukluklarla ilişkisi bilimsel veriler eşliğinde aktarılmıştır. Sonuç olarak, psikobiyotikler ve diğer fonksiyonel mikrobiyal bileşenler, geleneksel beslenme yaklaşımlarının ötesine geçerek hem fiziksel hem de zihinsel sağlığın bütüncül desteklenmesinde önemli bir rol oynamaktadır. Bu alandaki araştırmaların artması, bireylerin yaşam kalitesini artırabilecek yenilikçi beslenme stratejilerinin geliştirilmesine katkı sağlayacaktır.

Keywords

• : psikobiyotik
• beslenme
• mental sağlık
• postbiyotik
• parabiyotik

The Place of Psychobiotics in Nutrition: Ushering in a New Era of Functional Foods

Abstract

Psychobiotics are a novel class of functional food components that influence mental health by modulating the gut microbiota. Acting through the gut-brain axis, these components have been increasingly recognized as complementary approaches in the management of psychiatric conditions such as depression, anxiety, and stress. Alongside psychobiotics, other microbial-derived biotic compounds, including postbiotics and parabiotics, have garnered attention in recent years. Despite being non-viable microbial products or inactivated microorganisms, they provide beneficial effects by supporting immune functions, reducing inflammation, and strengthening the gut barrier. This review comprehensively examines the concept of psychobiotics and evaluates the health impacts of postbiotics and parabiotics based on current scientific literature. The interaction between microbial metabolites and the nervous system is discussed within the framework of functional foods, highlighting their potential therapeutic roles. Furthermore, the association of psychobiotics with depression, anxiety, and other mental disorders is presented with supporting scientific evidence. In conclusion, psychobiotics and related functional microbial components transcend traditional nutrition, playing a significant role in the holistic support of both physical and mental health. The expansion of research in this field promises to contribute to the development of innovative dietary strategies aimed at improving individual quality of life.

Keywords

• psychobiotics
• nutrition
• mental health
• postbiotics
• parabiotics

References

1. Aguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A.F., Vallejo-Cordoba, B., & Hernández-Mendoza, A. (2018). Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology, 75, 105-114. doi.org/10.1016/j.tifs.2018.03.009.
2. Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., ...& Reiter, R. J. (2016). Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer’s disease: A randomized, double-blind and controlled trial. Frontiers in Aging Neuroscience, 13, 688. https://doi.org/10.3389/fnagi.2016.00256
3. Binda, S., Tremblay, A., Iqbal, U.H., Kassem, O., Le Barz, M., Thomas, V., Bronner, S., Perrot, T., Ismail, N., Parker, J. (2024). Psychobiotics and the Microbiota–Gut–Brain Axis: Where Do We Go from Here? Microorganisms, 12 : 634. 10.3390/mikroorganizmalar12040634.
4. Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., ... & Cryan, J. F. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences, 108(38), 16050-16055. doi.org/10.1073/pnas.1102999108.
5. Chung, Y.-C., Jin, H.-M., Cui, Y., Kim, D. S., Jung, J. M., Park, J. I., & Jung, E. S. (2021). Fermented milk containing Lactobacillus plantarum reduces depressive and anxiety symptoms in healthy young adults: A randomized controlled trial. Nutrients, 13(8), 2633. https://doi.org/10.3390/nu13082633
6. Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., ... & Cryan, J. F. (2013). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry, 19(6), 666-673. doi.org/10.1038/mp.2012.77.
7. Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701-712. doi.org/10.1038/nrn3346.
8. Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019). The role of short-chain fatty acids in microbiota–gut–brain communication. Nature Reviews Gastroenterology & Hepatology, 16(8), 461-478. doi.org/10.1038/s41575-019-0157-3.

9. Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2022). The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research, 157, 365–372. https://doi.org/10.1016/j.jpsychires.2022.01.014
10. Dinan, T. G., Stanton, C., & Cryan, J. F. (2013). Psychobiotics: a novel class of psychotropic. Biological Psychiatry, 74(10), 720-726. doi.org/10.1016/j.biopsych.2013.05.001.
11. Dinan, T. G., & Cryan, J. F. (2017). Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. The Journal of Physiology, 595(2), 489-503.doi.org/10.1113/JP273106.
12. Foster, J. A., & McVey Neufeld, K. A. (2013). Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, 36(5), 305-312. dx.doi.org/10.1016/j.tins.2013.01.005.
13. Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502. https://doi.org/10.1038/nrgastro.2017.75.
14. Huang, Y., Gao, Y., Duan, Y., Xu, L., & Xu, Y. (2023). Psychobiotics as modulators of brain–gut–microbiota axis in stress-related disorders: A randomized, double-blind, placebo-controlled study. Nutrients, 15(4), 895. https://doi.org/10.3390/nu15040895.
15. Kelly, J. R., Borre, Y., C OB, J. F., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., Hoban, A. E., Scott, L., Fitzgerald, P., Stanton, C., & Dinan, T. G. (2016). Transferring the blues: Depression-associatedgut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109-118. https://doi.org/10.1016/j.jpsychires.2016.07.019.
16. Lew, L.-C., Hor, Y.-Y., Yusoff, N. A. A., Choi, S.-B., Yusoff, M. S. B., Roslan, N. S., ... & Liong, M.-T. (2019). Probiotic Lactobacillus plantarum DR7 reduces stress and anxiety in adults: A randomized, double-blind placebo-controlled study. Clinical Nutrition, 38(5), 2053–2064. https://doi.org/10.1016/j.clnu.2018.09.010.
17. Liu, G., Santana-Gonzalez, C., Zeffıro, TA., Zhang, N., Engstrom, M., Quevedo, K. (2023). Self-compassion and neural activity during self-appraisals in depressed and healthy adolescents. Journal of Affective Disorders, 339, 717–724. https://doi.org/10.1016/j.jad.2023.07.012.
18. Marco, M. L., Heeney, D., Binda, S., Cifelli, C. J., Cotter, P. D., Foligné, B., ... & Hutkins, R. (2017). Health benefits of fermented foods: microbiota and beyond. Current Opinion in Biotechnology, 44, 94-102. doi.org/10.1016/j.copbio.2016.11.010.
19. Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014). Gut microbes and the brain: paradigm shift in neuroscience. The Journal of Neuroscience, 35(21), 13884- 13893. doi.org/10.1523/JNEUROSCI.3299-14.2014.
20. Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., ... & Cazaubiel, M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764. doi.org/10.1017/S0007114510004319.
21. Mudaliar, S. B. (2024). Probiotics and Paraprobiotics: Effects on Microbiota-Gut-Brain Axis and Their Consequent Potential in Neuropsychiatric Therapy. Frontiers in Neuroscience, 16, 859231. https://doi.org/10.3389/fnins.2022.859231.
22. Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W. S. (2018). A meta-analysis of the use of probiotics to alleviate depressive symptoms. Journal of Affective Disorders, 228, 13-19. https://doi.org/10.1016/j.jad.2017.11.063.
23. Novoa Díaz, M. B., Carriere, P., & Gentili, C. (2023). How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells. World Journal of Stem Cells, 15(5), 281–301. doi.org/10.4252/wjsc.v15.i5.281.
24. Obayomi, OV., Olaniran, AF., Owa, SO. (2024). Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review, Journal of Functional Foods, 119:106337, 1756-4646. doi.org/10.1016/j.jff.2024.106337.
25. O'Mahony, S. M., Clarke, G., Borre, Y., Dinan, T. G., & Cryan, J. F. (2015). Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behavioural Brain Research, 277, 32-48. https://doi.org/10.1016/j.bbr.2014.07.027.
26. Rafique, N., Zafar, M. I., Akhtar, M. F., Saleem, U., Ali, A., & Jahan, S. (2023). Promising bioactivities of postbiotics: A comprehensive review. Journal of Agriculture and Food Research, 14, 100708. https://doi.org/10.1016/j.jafr.2023.100708.
27. Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR ve diğerleri (2019) Otizmli ve gastrointestinal semptomları olan çocuklarda bağırsak fonksiyonu üzerinde probiyotik/kolostrum takviyesinin pilot çalışması. PLoS One 14(1): e0210064. https://doi.org/10.1371/journal.pone.0210064
28. Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. (2016). Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends in neurosciences, 39(11), 763-781. dx.doi.org/10.1016/j.tins.2016.09.002.
29. Schwab, C., Coulibaly-Zerbo, P., Zengler, K., Röth, R., Baumeister, D., & Otte, C. (2022). Clinical, gut microbial, and neural effects of a probiotic add-on therapy in major depressive disorder: A randomized controlled trial. Translational Psychiatry, 12(1), 1–10. https://doi.org/10.1038/s41398-022-01977-z.
30. Taverniti, V., & Guglielmetti, S. (2011). The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept). Genes & Nutrition, 6(3), 261-274. doi.org/10.1007/s12263-011-0218-x.
31. Yanni, A., & Kourkoutas, Y. (2022). Functional Foods and Bioactive Compounds for Improving and Maintaining Digestive Health (Editorial). Frontiers in Nutrition, 8: 815370. doi.org/10.3389/fnut.2021.815370.
32. Westfall, S., Lomis, N., Kahouli, I., Dia, S., Singh, S. P., & Prakash, S. (2021). Microbiome, probiotics and neurodegenerative diseases: deciphering the gut-brain axis. Cellular and Molecular Life Sciences, 78(3), 1233–1254. https://doi.org/10.1007/s00018-020-03684-9.