A New Case of DRESS Syndrome Induced by Allopürinol and Triggered by Ceftriaxon

Year 2019, Volume: 19 Issue: 2, 445 - 449, 28.06.2019

Muhammet Kızmaz Burcu Kumtepe Kurt Ayşe Karadağ

https://doi.org/10.17098/amj.582030

Abstract

DRESS syndrome (drug rash with eosinophilia
and systemic symptoms) is a rare, acute, severe, life-threatening drug
reaction; characterized by fever, rash, internal organ involvement. We present
a 71 years old female patient with DRESS syndrome induced by allopürinol and
triggered by ceftriaxone.

Keywords

allopurinol, ceftriaxone, side effect

Allopürinol'ün Neden Olduğu ve Seftriakson Tarafından Tetiklenen Yeni Bir DRESS Sendromu Olgusu

Abstract

DRESS sendromu (Drug
Rash with Eosinophilia and Systemic Symptoms)
ateş, cilt döküntüsü, iç organ tutulumuyla karakterize yaşamı tehdit edebilen
ender, akut başlangıçlı, şiddetli bir ilaç reaksiyonudur. Bu yazıda allopürinol
ile indüklenen ve seftriakson tarafından tetiklenen DRESS sendromlu 71 yaşında
bir kadın hasta sunuyoruz.

Keywords

allopürinol, seftriakson, yan etki

References

• Singer JZ, Wallace SL. The allopurinol hypersensitivity syndrome. Unnecessary morbidity and mortality. Arthritis Rheum 1986;29:82-7.
• Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg. 1996; 15(4): 250-7.
• Yücel A, Karakuş G, Günaştı S. Psikotrop ilaçların dermatolojik yan etkileri ve tedavi yaklaşımları. Klinik Psikofarmakoloji Bülteni. 2008; 18: 235-44.
• Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al: Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2007;156:609-11.
• S Yaylacı, M V Demir, T Temiz, et al: Allopurinol-induced DRESS syndrome. Indian J Pharmacol. 2012 May-Jun; 44: 412–4.
• DINCER, Emre, et al. Tüberküloz, ateş ve döküntü: bir olgu sunumu. Journal of Pediatric Infection/Cocuk Enfeksiyon Dergisi, 2009, 3.2.
• Akcam FZ, Aygun FO, Akkaya VB. DRESS like severe drug rash with eosinophilia, atypic lymphocytosis and fever secondary to ceftriaxone. J Infect. 2006 Aug;53(2):e51-3.
• Vivek S. Guleria, Mukesh Dhillon, Shaman Gill, et al. Ceftriaxone induced drug rash with eosinophilia and systemic symptoms. J Res Pharm Pract. 2014 Apr-Jun; 3(2): 72–4.
• Yang CY, Dao RL, Lee TJ, et al: Severe cutaneous adverse reactions to antiepileptic drugs in Asians. Neurology 2011;77:2025-33.
• Chen YC, Chiu HC, Chu CY: Drug Reaction With Eosinophilia and Systemic Symptoms: A Retrospective Study of 60 Cases. Arch Dermatol 2010;146:1373-9.