Antioxidative capacities of some GABAA receptor modulating food plants

Year 2019, , 237 - 242, 20.12.2019

Sümeyye Şahin

https://doi.org/10.29278/azd.602839

Abstract

Reactive oxygen species cause oxidative stress associated with some
health issues such as neurodegenerative diseases. Some antioxidants show
neuroprotective activity and regulate neuronal activity through positive
modulation of GABA_A receptors. In this study, the antioxidative capacity of some novel GABA_A
receptor modulating food plants, including lavender, clove and four Sideritis species (S. arguta, S. sipylea, S. condensata, and S.
stricta) was investigated using ABTS assay. The aqueous clove extract
showed the most potent antioxidant effect and its IC₅₀ value was
found to be 3.76 μg/mL. The antioxidant capacity of Trolox was lower (IC₅₀:
4.63 μg/mL) than that of the clove extract, but higher than those of the other
food extracts. The aqueous lavender extract exhibited less antioxidant activity
compared to Sideritis species, except
S. sipylea that had the least
antioxidant capacity (IC₅₀: 20.75 μg/mL). In conclusion, these
results confirm that GABA_Areceptor modulating food plants possess strong antioxidative activity.

Keywords

Sideritis, Lavanta, Karanfil

References

• Alnamer, R., Alaoui, K., Bouidida el, H., Benjouad, A., Cherrah, Y., 2012. Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco. Advances in Pharmacological Sciences, 2012: 270824.
• Alqareer, A., Alyahya, A., Andersson, L., 2006. The effect of clove and benzocaine versus placebo as topical anesthetics. Journal of Dentistry, 34(10): 747-750. Aoshima, H., Hamamoto, K., 1999. Potentiation of GABAA Receptors Expressed in Xenopus Oocytes by Perfume and Phytoncid. Bioscience, Biotechnology, and Biochemistry, 63(4): 743-748.
• Carlsen, M. H., Halvorsen, B. L., Holte, K., Bøhn, S. K., Dragland, S., Sampson, L., Willey, C., Senoo, H., Umezono, Y., Sanada, C., Barikmo, I., Berhe, N., Willett, W. C., Phillips, K. M., Jacobs, D. R., Blomhoff, R., 2010. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutrition Journal, 9: 3.
• Charimi, M. T., Lazari, D., Karioti, A., Skaltsa, H., Hadjipavlou-Litina, D., Souleles, C., 2008. Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae). Phytotherapy Research, 22(4):450-454.
• Gonzalez-Burgos, E., Carretero, M. E., Gomez-Serranillos, M. P., 2011. Sideritis spp.: Uses, chemical composition and pharmacological activities - A review. Journal of Ethnopharmacology, 135 (2): 209-225.
• Granger, R. E., Campbell, E. L., Johnston, G. A. R., 2005. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant a1b2g2L GABAA receptors. Biochemical Pharmacology, 69(7): 1101-1111. Gulcin, I., 2011. Antioxidant activity of eugenol: a structure-activity relationship study. Journal of Medicinal Food, 14(9): 975-985.
• Gülçin, İ., Şat, G., Beydemir, Ş., Elmastaş, M., Küfrevioğlu, Ö. İ., 2004. Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.). Food Chemistry, 87(3): 393-400.
• Güvenç, A., Houghton, P.J., Duman, H., Coşkun, M., Şahin, P., 2008. Antioxidant activity studies on selected Sideritis species Native to Turkey. Pharmaceutical Biology, 43(2): 173-177. Ha J. H., L. D. U., Lee J. T., Kim J. S., Yong C. S., Kim J. A., Ha J. S., Huh K., 2000. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. Journal of Ethnopharmacology, 73(1-2): 329-333.
• Halder, S., Mehta, A. K., Mediratta, P. K., Sharma, K. K., 2012. Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 385: 587-593. Hernandez-Perez, M., Sanchez-Mateo, C. C., Montalbetti-Moreno, Y., Rabanal, R. M., 2004. Studies on the analgesic and anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part. Journal of Ethnopharmacology, 93(2-3): 279-284.
• Hosseini, M., Kamkar-Asl, M., Rakhshandeh, H., 2011. Analgesic effect of clove essential oil in mice. Avicenna Journal of Phytomedicine, 1(1): 1-6.
• Kessler, A., Sahin-Nadeem, H., Lummis, S. C., Weigel, I., Pischetsrieder, M., Buettner, A., Villmann, C., 2014. GABAA receptor modulation by terpenoids from Sideritis extracts. Molecular Nutrition & Food Research, 58(4): 851-862.
• Kessler, A., Villmann, C., Sahin-Nadeem, H., Pischetsrieder, M., Buettner, A., 2012. GABAA receptor modulation by the volatile fractions of Sideritis species used as ‘Greek’ or ‘Turkish’ mountain tea. Flavour and Fragrance Journal, 27(4): 297-303.
• Lee, K. J., Oh, Y. C., Cho, W. K., Ma, J. Y., 2015. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evidence-Based Complementary and Alternative Medicine, 2015: 165457.
• Möhler, H., 2006. GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia. Journal of Receptors and Signal Transduction, 26(5-6): 731-740.
• Reiter, R. J., 1998. Oxidative damage in the central nervous system: protection by melatonin. Progress in Neurobiology, 56(3): 359-384.
• Sahin, S., Eulenburg, V., Heinlein, A., Villmann, C., Pischetsrieder, M., 2017. Identification of eugenol as the major determinant of GABA A -receptor activation by aqueous Syzygium aromaticum L. (clove buds) extract. Journal of Functional Foods, 37: 641-649.
• Sahin, S., Eulenburg, V., Kreis, W. Villmann, C., Pischetsrieder, M., 2016. Three-Step Test System for the Identification of Novel GABAA Receptor Modulating Food Plants. Plant Foods for Human Nutrition, 71(4): 355-360.
• Sesti, F., Liu, S., Cai, S. Q., 2010. Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration? Trends in Cell Biology, 20(1): 45-51.
• Shaw, D., Annett, J. M., Doherty, B., Leslie, J. C., 2007. Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomedicine, 14(9): 613-620.
• Sigel, E., Steinmann, M. E., 2012. Structure, function, and modulation of GABAA receptors. Journal of Biological Chemistry, 287(48): 40224-40231.
• Silva, M. I., Silva, M. A., de Aquino Neto, M. R., Moura, B. A., Sousa, H. L., de Lavor, E. P. H., de Vasconcelos, P. F., Macêdo, D. S., de Sousa, D. P., Vasconcelos, S. M., de Sousa, F. C., 2009. Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. Fitoterapia, 80(8): 506-513.
• Silva, G. L., Luft, C., Lunardelli, A., Amaral, R. H., Melo, D. A., Donadio, M. V., Nunes, F.B., de Azambuja, M. S., Santana, J. C., Moraes, C. M., Mello, R. O., Cassel, E., Pereira, M. A., de Oliveira, J. R., 2015. Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil. Anais da Academia Brasileira de Ciências, 87(2):1397-1408
• Willcox, J. K., Ash, S. L., Catignani, G. L., 2004. Antioxidants and prevention of chronic disease. Critical Reviews in Food Science and Nutrition, 44(4): 275-295.
• Woronuk, G., Demissie, Z., Rheault, M., Mahmoud, S., 2011. Biosynthesis and therapeutic properties of Lavandula essential oil constituents. Planta Medica, 77(1): 7-15.
• Wu, C., Gopal, K. V., Moore, E. J., Gross, G. V., 2014. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. Journal of Neural Transmission, 121(7): 683-693.
• Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., Dexter, D. T., 2005. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radical Research, 39(10): 1119-1125.