Antioxidative capacities of some GABAA receptor modulating food plants
Öz
Reactive oxygen species cause oxidative stress associated with some
health issues such as neurodegenerative diseases. Some antioxidants show
neuroprotective activity and regulate neuronal activity through positive
modulation of GABAA receptors. In this study, the antioxidative capacity of some novel GABAA
receptor modulating food plants, including lavender, clove and four Sideritis species (S. arguta, S. sipylea, S. condensata, and S.
stricta) was investigated using ABTS assay. The aqueous clove extract
showed the most potent antioxidant effect and its IC50 value was
found to be 3.76 μg/mL. The antioxidant capacity of Trolox was lower (IC50:
4.63 μg/mL) than that of the clove extract, but higher than those of the other
food extracts. The aqueous lavender extract exhibited less antioxidant activity
compared to Sideritis species, except
S. sipylea that had the least
antioxidant capacity (IC50: 20.75 μg/mL). In conclusion, these
results confirm that GABAAreceptor modulating food plants possess strong antioxidative activity.
Anahtar Kelimeler
Kaynakça
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